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Ethylmercury Chloride

HCID 7862
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
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Basic information

CAS
107-27-7
Standard SMILES
C[CH2][Hg][Cl]
InChIKey
QWUGXIXRFGEYBD-UHFFFAOYSA-M
Molecular formula
C2H5ClHg
Average molar mass
265.1 g/mol
Monoisotopic mass
265.978621

Overview

Ethyl mercury chloride appears as silver iridescent crystals or white fluffy solid. Sublimes easily. Sensitive to light. Highly toxic. Causes skin burns and is absorbed through the skin.

Names & identifiers

Preferred name
Ethylmercury Chloride
IUPAC
chloro(ethyl)mercury
English name
Ethylmercuric chloride
Molecular formula
C2H5ClHg
Molecular weight
265.1

Names & synonyms

ETHYLMERCURY CHLORIDEEthylmercuric chlorideChloroethylmercury107-27-7CryptodineGranozanGanozanMercury, chloroethyl-Emcon Dchloro(ethyl)mercuryEthylmerkurichloridEthyl Mercury Chloride
Show more names
EMCC2H5HgClEthylmercuric chloride(Technical)emcondCeresanGranosan
Monoethylmercury chlorideethylmercury(II) chlorideCHEBI:152058M04218TP6PNSC-1203Chloride, EthylmercuryChloride, EthylmercuricChloride, Ethyl Mercury

Database identifiers

CAS
107-27-7
PubChem CID
7862
ChEBI
CHEBI:152058
EC Number
203-478-0

Properties

Computed structural properties

Topological polar surface area
0 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
0
Rotatable bonds
0
Heavy atoms
4
Formal charge
0
Complexity
10

Experimental & physicochemical properties

Chemical ClassesMetals -> Metals, Organic Compounds
Density3.482 (NTP, 1992) - Denser than water; will sink
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Boiling PointSublimes (NTP, 1992)
Melting Point · 2 items

378 °F (NTP, 1992)

192 °C

Vapor Pressure6.44 [mmHg]
Physical Description · 2 items

Ethyl mercury chloride appears as silver iridescent crystals or white fluffy solid. Sublimes easily. Sensitive to light. Highly toxic. Causes skin burns and is absorbed through the skin.

White silvery solid; Insoluble in water; [Merck Index] Silver crystalline solid; Insoluble in water; [Alfa Aesar MSDS]

Physicochemical properties

Melting point
195 °C · 195°C
Density

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1 item

SYMPTOMS: Symptoms of exposure to this compound may include headache, paresthesia of the tongue, lips, fingers and toes, other nonspecific dysfunction, metallic taste, slight gastrointestinal disturbances, excessive flatulence and diarrhea Acute poisoning may cause irritation of the gastrointestinal tract and renal failure. Nervous symptoms usually appear first. They include fine tremors of extended hands, loss of side vision and slight loss of coordination. Other symptoms include incoordination in speech, writing and gait. Incoordination progresses to inability to stand or carry out voluntary movements. Muscle atrophy, flexure contractions, generalized myoclinic movements, difficulty understanding speech, irritability and bad temper progressing to mania, stupor coma and mental retardation may occur. Symptoms of exposure to this type of compound include central nervous system effects, ataxia, chorea, athetosis and convulsions. Ingestion of this type of compound may cause urticaria, stomatitis, salivation, anemia, leukopenia and liver damage. Inhalation of this type of compound can cause salivation, stomatitis, loosening of the teeth, blue lines on gums, pain and numbness in the extremities, nephritis, anxiety, weight loss, anorexia, mental depression, insomnia, irritability, instability, hallucinations and evidences of mental deterioration. This class of compound is a primary skin irritant which may cause dermatitis, skin burns and sensitization.

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Organic mercury is absorbed mainly by the gastrointestinal tract, then distributed throughout the body via the bloodstream. Organic mercury complexes with free cysteine and the cysteine and sulfhydryl groups on proteins such as haemoglobin. These complexes are able to mimic methionine and thus be transported throughout the body, including through the blood-brain barrier and placenta. Organic mercury is metabolized into inorganic mercury, which is eventually excreted in the urine and faeces. (T11)

MeSH Pharmacological ClassificationChemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.

Uses & manufacturing

Uses · 2 items

Used as a seed treatment fungicide; [Merck Index] Used as a polymerization catalyst; [NTP] No active pesticide product registrations in the US; [NPIRS]

Farming (Pesticides) [Category: Industry]

Applications · 3 items

UsesEthyl mercuric chloride is used as the polymerization catalyst; seed or bulb fungicide.

UsesApplied at 2% strength (soln or mixed with solids) as a fungicide for treating seeds.

General DescriptionSilver iridescent crystals or white fluffy solid . Sublimes easily. Sensitive to light. Highly toxic. Causes skin burns and is absorbed through the skin.

Upstream & downstream products

Upstream raw materials

TetraethyltinEthylaluminum dichloride

Related reactions

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
3.482 · 3.482
solubility
Chloroform (Slightly)
form
solid
Water Solubility
Insoluble in water. Slightly soluble in ether. Soluble in hot alcohol. Sublimes readilyInsoluble in water. Slightly soluble in ether. Soluble in hot alcohol.
Merck
14 · 14,3826
Henry's Law Constant
1.5 · 1.5×101 mol/(m3Pa) at 25℃, Abraham et al. (2008)
Exposure limits
10 mg/m3; · NIOSH: IDLH 10 mg/m3; TWA 0.05 mg/m3; Ceiling 0.1 mg/m3
Stability
Stable. Incompatible with strong oxidizing agents. May be light sensitive.
CAS DataBase Reference
107 · 107-27-7(CAS DataBase Reference)
FDA UNII
4218 TP6P · M04218TP6P
EPA Substance Registry System
Mercury, chloroethyl- (107-27-7)
Symbol(GHS)
6 · GHS06,GHS08,GHS09
Hazard statements
300 · H300-H310-H330-H373-H400-H410
Precautionary statements
301 · P301+P310a-P304+P340-P320-P330-P405-P501a
Hazard Codes
T+,N
Risk Statements
26 · 26/27/28-33-50/53
Safety Statements
13 · 13-28-36-45-61-60
RIDADR
2025 · 2025
RTECS
9800000 · OV9800000
HazardClass
6.1 · 6.1
PackingGroup
II
HS Code
28521000 · 28521000
Toxicity
50 · mammal (species unspecified),LD50,unreported,18mg/kg (18mg/kg),"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 287, 1971.
Hazards Summary · 1 item

Corrosive to skin; Chronic exposure may cause brain injury; Can be absorbed through skin; [Merck Index] Causes other degenerative changes to brain, other liver changes, weight loss, and changes in renal tubules in repeated-dose oral studies of rats; [RTECS] An irritant; Highly toxic by ingestion, inhalation, and skin absorption; May have cumulative adverse effects; Mutagenic and reproductive effects observed in experimental animals; [Alfa Aesar MSDS] See Methylmercuric chloride. See Mercury, alkyl compounds and linked occupational diseases.

Reactive GroupOrganometallics
Reactivity ProfileETHYL MERCURY CHLORIDE is sensitive to prolonged exposure to light. Incompatible with strong oxidizers such as chlorine (NTP, 1992).
Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 2 (100%)

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Minimum Risk LevelChronic Inhalation: 0.0002 mg/m3 (L134)
Threshold Limit Values (TLV) · 2 items

0.01 [mg/m3], as Hg

0.03 [mg/m3], as Hg

Permissible Exposure Limit (PEL)0.01 [mg/m3], as Hg, Ceiling(OSHA) = 0.04 mg/m3, as Hg
Protective Action Criteria (PAC) · 3 items

0.0037 [ppm]

0.25 [ppm]

0.50 [ppm]

Personal Protective Equipment (PPE)MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Immediately Dangerous to Life or Health (IDLH) · 2 items

2 mg Hg/m3 (NIOSH, 2024)

2.0 [mg/m3], as Hg

Toxicology

TreatmentMercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)
Health Effects · 1 item

Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Exposure RoutesOral (L7) ; inhalation (L7) ; dermal (L7)
Toxicity Summary · 1 item

High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)

Signs and SymptomsCommon symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)
Carcinogen ClassificationNo indication of carcinogenicity (not listed by IARC). (L135)
Toxicity Data · 2 items

LC50 (rat) = 689 mg/m3/4hr

LD50: 40 mg/kg (Oral, Rat) (L329) LD50: 200 mg/kg (Dermal, Rat) (L329) LC50: 5 mg/m3 (Inhalation, Mouse) (L329)

Safety data

rtecs
OV9800000
ridadr
2025
hs_code
28521000
Toxicity
mammal (species unspecified),LD50,unreported,18mg/kg (18mg/kg),"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 287, 1971.
risk_code
26/27/28-33-50/53
Symbol(GHS)
GHS06,GHS08,GHS09
hazard_code
T+,N
safety_code
13-28-36-45-61-60
hazard_class
6.1
packing_group
II
Hazard statements
H300-H310-H330-H373-H400-H410
Precautionary statements
P301+P310a-P304+P340-P320-P330-P405-P501a
Tetraethyllead
Diethyl mercury
Diethylaluminum chloride
Triethylaluminum

Downstream products

Borane, dichloro(pentafluorophenyl)-Lead diethyl dichlorideTriethyllead chlorideTriethyltin chlorideAluminum chloride

Additional notes

DefinitionChEBI: Ethylmercuric chloride is a highly toxic organomercury compound which is used as a fungicide for treating seeds. It has a role as a fungicide. It is a chlorine molecular entity and an organomercury compound.