Basic information
- Standard SMILES
O=[N+]([O-])c1ccccc1NCCO- InChIKey
LFOUYKNCQNVIGI-UHFFFAOYSA-N- Molecular formula
- C8H10N2O3
- Average molar mass
- 182.18 g/mol
- Monoisotopic mass
- 182.06914218
Overview
The CIR Expert Panel concludes that HC Yellow No. 2 is safe for use in hair dyes at concentrations up to 3%. The limitation on the concentration is based upon the available clinical sensitization data.
Names & identifiers
- Preferred name
- HC Yellow No. 2
- IUPAC
- 2-(2-nitroanilino)ethanol
- English name
- 2-Nitro-N-hydroxyethyl aniline
- Molecular formula
- C8H10N2O3
- Molecular weight
- 182.18
Names & synonyms
4926-55-02-((2-Nitrophenyl)amino)ethanolHC Yellow no. 22-[(2-nitrophenyl)amino]ethanolEthanol, 2-[(2-nitrophenyl)amino]-Jarocol Yellow 2Colorex HCY2UNII-9FVT2KMV9O9FVT2KMV9OCovariane Jaune W 1122NSC 68401Ethanol, 2-((2-nitrophenyl)amino)-
Show more names
HC YELLOW NO 2hc-yelow 22-Nitro-N-hydroxyethNitroanilino)EthanolAdrenaline Impurity 1032-(2-Nitroanilino)Ethanolethanol, 2-(o-nitroanilino)-N-Hydroxyethyl-2-nitroaniline
EINECS 225-555-8HC YELLOW 2NSC 33878NSC-33878NSC-68401DTXSID0063650NSC33878NSC68401
Database identifiers
- CAS
4926-55-0- PubChem CID
- 78637
- DTXSID
DTXSID0063650- UNII
- 9FVT2KMV9O
- EC Number
- 225-555-8
- Nikkaji
- J262.526A
Properties
Computed structural properties
- XLogP
- 1.5
- Topological polar surface area
- 78.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 169
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (HC Yellow No. 2) -> CIR (Cosmetic Ingredient Review)
Hair dyeing
Physicochemical properties
- Melting point
- 71 · 71-73°C
- Boiling point
- 376.6 · 376.6±22.0 °C(Predicted)
- Density
- 1.352 · 1.352±0.06 g/cm3(Predicted)
- vapor pressure
- 0 Pa · 0Pa at 20℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.6 · 14.60±0.10(Predicted)
- color
- Dark Orange to Red
- Water Solubility
- 1.85 g/L · 1.85g/L at 20℃
- λmax
- 441 nm · 441nm(NaOH aq.)(lit.)
- Cosmetics Ingredients Functions
- HAIR DYEING
- Cosmetic Ingredient Review (CIR)
- 2 · 2-Nitro-N-hydroxyethyl aniline (4926-55-0)
- InChI
- InChI=1S/C8H10N2O3/c11-6-5-9-7-3-1-2-4-8(7)10(12)13/h1-4,9,11H,5-6H2
- InChIKey
- LFOUYKNCQNVIGI-UHFFFAOYSA-N
- SMILES
- C(O)CNC1=CC=CC=C1[N+]([O-])=O
- LogP
- 1.5 at · 1.5 at 20℃
- CAS DataBase Reference
- 4926 · 4926-55-0(CAS DataBase Reference)
- EWG's Food Scores
- 3 · 3-5
- FDA UNII
- 9 FVT2KMV9O · 9FVT2KMV9O
- EPA Substance Registry System
- 2 · Ethanol, 2-[(2-nitrophenyl)amino]- (4926-55-0)
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 264 · P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- TSCA
- TSCA listed
- HS Code
- 2922290090 · 2922290090
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1.2% (1 of 83) of reports.
Warning
H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 83 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
Hazard information
Regulatory Information
Chemical: Ethanol, 2-[(2-nitrophenyl)amino]-
REACH registered substance: 2-[(2-nitrophenyl)amino]ethanol (EC: 225-555-8)
Ethanol, 2-[(2-nitrophenyl)amino]-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Ethanol, 2-[(2-nitrophenyl)amino]-: Human health tier II assessment
Hazard Classes and Categories
Acute Tox. 4 (97.6%)
Acute toxicity (ingestion) - category 4
Toxicology
Toxicity Summary
The CIR Expert Panel concludes that HC Yellow No. 2 is safe for use in hair dyes at concentrations up to 3%. The limitation on the concentration is based upon the available clinical sensitization data.
Safe for use in cosmetics, with qualifications
Safety data
- tsca
- TSCA listed
- hs_code
- 2922290090
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- hazard_note
- Irritant
- Hazard statements
- H315-H319
- REACH Registrations
- Active
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: HC Yellow No. 2
Household ProductsInformation on 14 consumer products that contain HC Yellow No. 2 in the following categories is provided:
Use ClassificationCosmetics -> Hair dyeing
General Manufacturing InformationEthanol, 2-[(2-nitrophenyl)amino]-: ACTIVE
Applications
Uses2-(2-Nitroanilino)ethanol is used in the preparation of (phenylamino)quinoxalinone derivatives which has been identified as a new class of glycogen phosphorylase inhibitors.
Upstream & downstream products
Upstream raw materials
Suppliers50 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
杭州创引化工科技有限公司0571-87086220 13516718938 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
南京凯美西化工有限公司02558748998 18951874644 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
武汉欣扬瑞和化学科技有限公司13720274133 · [email protected]
上海腾准生物科技有限公司19821570922 · [email protected]
武汉欣扬瑞和化学科技有限公司18171205315; 18171205315 · [email protected]
无锡市凯立生物科技有限公司0510-80721533 13327925606 · [email protected]
南京科朗科技有限公司025-58748998 18951874644 · [email protected]
普善实业（陕西）有限公司029-81310890 18165209495 · [email protected]
杭州倍生元生物科技有限公司15700194842 15700194842
武汉科美沃化工有限公司+86-2785736489 +8618171418573 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
广州隽唐科技有限公司020-36607679 13502246435 · [email protected]
郑州鸿晟医药科技有限公司0371-55695890 15637198702 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
陕西纬宇新材料有限公司13772052144 13772052144 · [email protected]
湖北兴琰新材料科技有限公司13129948835 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
湖北长耀生物科技有限公司17683887209 17683887209 · [email protected]
广东云星生物技术有限公司0751-18902340975/189023400307 18902340307 · [email protected]
希瓦生物科技（广州）有限公司13268215580 · [email protected]
上海景颜化工科技有限公司13817811078 · [email protected]
超彩实业有限公司0574-83851061 · [email protected]
上海泰坦科技股份有限公司400-6009262 15618770481 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
Xiamen AmoyChem Co., Ltd+86-86-5926051114 · [email protected]
武汉科美沃化工有限公司027-85736489 · [email protected]
上海遐瑞医药科技有限公司+86 21 61551611
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
成都麦卡希化工有限公司028-85632863 18108198598 · [email protected]
上海贤鼎生物科技有限公司4009209199 · [email protected]
深圳康特腾科技有限公司86-0755-86635001 · [email protected]
上海毕得医药科技股份有限公司400-164-7117 18317119277 · [email protected]
上海石洋化工有限公司021-56795766 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
湖北科易佳化工有限公司15629167229 · [email protected]
上海东帆化工科技有限公司+86 (21) 3450-0607 · [email protected]
湖北巨胜科技有限公司027-59599241 18871490274 · [email protected]
桦特昇生物科技（武汉）有限公司027-59207879 1972026995 18140587686 · [email protected]
广东翁江化学试剂有限公司0751-2815987 13927875076 · [email protected]
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