HuagongsheHuagongshe Chemistry Print Report · For research reference only
Biuret
BIURET REAGENT · IMIDODICARBONIC DIAMIDE · Dicarbonimidic diamide · iuret · Allophamicacidamide · L-101 · biure · BIURET
Identifiers & Physical Properties
| CAS No. | 108-19-0 |
|---|---|
| Molecular formula | C2H5N3O2 |
| Average molar mass | 103.08 g/mol |
| Monoisotopic mass | 103.03817641 g/mol |
| SMILES | NC(=O)NC(N)=O |
| InChIKey | OHJMTUPIZMNBFR-UHFFFAOYSA-N |
| PubChem CID | 7913 |
| ChEMBL | CHEMBL1889026 |
| ChEBI | CHEBI:18138 |
| EC No. | 203-559-0 |
| DTXSID | DTXSID2026783 |
Chemical & Physical Properties
| XLogP | -0.7 |
|---|---|
| Topological polar surface area | 98.2 |
| Hydrogen bond donors | 3 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 0 |
| Heavy atoms | 7 |
| Formal charge | 0 |
| Complexity | 87.1 |
| Chemical classes | Nitrogen Compounds -> Other Nitrogen Compounds |
| Drugs | Pharmaceuticals -> Metabolite of Metformin |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| Odor | ODORLESS |
| Density | 1.467 @ -5 °C/4 °C1.01 g/mL at 20 °C |
| Color/Form | ELONGATED PLATES FROM ETHANOLNEEDLES FROM WATER CRYSTALLIZING WITH 1 MOLECULE OF WATER PER MOLECULE OF COMPDWHITE NEEDLES |
| Solubility | SOL IN 100 G WATER: 2.01 G @ 25 °C, 7 G @ 50 °C, 20 G @ 75 °C, 53.5 G @ 105.5 °CFREELY SOL IN ALCOHOLVERY SLIGHTLY SOL IN ETHERDMSO (Slightly), Methanol (Slightly, Heated, Sonicated)2 g/100 mL (25 ºC) |
| Melting point | 190 °C, DECOMP185-190 °C (dec.) (lit.) |
| Physical Description | CBIWhite hygroscopic solid[HSDB] White odorless powder[Alfa Aesar MSDS] |
| Other Experimental Properties | HYGROSCOPICPYROLYSIS @ HIGH TEMP (GREATER THAN 193 °C) YIELDS MELAMINEWHEN CRYSTALLIZED FROM WATER, 5C2-H5-N3-O2.4H20 IS FORMED, WHICH BECOMES ANHYDROUS @ 110 °C, DECOMP @ ABOUT 193 °CAQ SOLN TREATED WITH CUPRIC SULFATE & SODIUM HYDROXIDE GIVE REDDISH-VIOLET COLOR |
| Boiling point | 100 °C |
| Refractive index | 1.4264 (estimate) |
| Storage conditions | 2-8°C |
| pKa (acidity coefficient) | 10.17±0.46(Predicted) |
| Physical state | Liquid |
| Color | White |
| Sensitivity | Hygroscopic |
| Merck | 14,1309 |
| BRN | 1703510 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. Hygroscopic. |
| InChI | 1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7) |
| InChIKey | OHJMTUPIZMNBFR-UHFFFAOYSA-N |
| SMILES | NC(=O)NC(N)=O |
| CAS DataBase Reference | 108-19-0(CAS DataBase Reference) |
| FDA UNII | 89LJ369D1H |
| NIST Chemistry Reference | Imidodicarbonic diamide(108-19-0) |
| EPA Substance Registry System | Imidodicarbonic diamide (108-19-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.32 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P405-P501a-P305+P351+P338 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37-36 |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| Customs code | 29241990 |
| Storage class | 11 - Combustible Solids |
| Hazardous substances data | 108-19-0(Hazardous Substances Data) |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 135 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Chemical: Imidodicarbonic diamideImidodicarbonic diamide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Imidodicarbonic diamide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Imidodicarbonic diamide: Does not have an individual approval but may be used under an appropriate group standard |
| Hazards summary | Mildly bacteriostatic and diuretic in ratsAlso causes drop in blood pressure, marked urinary tract irritation, and increases in pepsin activity[Merck Index] A skin and strong eye irritant[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Explosive Limits and Potential | DURING CHLORINATION OF IMPURE BIURET IN WATER @ 20 °C, A VIOLENT EXPLOSION OCCURRED. THIS WAS ATTRIBUTED TO CONVERSION OF THE CYANURIC ACID IMPURITY (3%) TO NITROGEN TRICHLORIDE & SPONTANEOUS EXPLOSION OF THE LATTER. |
| Non-Human Toxicity Excerpts | HAS WEAK...DIURETIC PROPERTIES IN RATS, ALSO CAUSES A FALL IN BLOOD PRESSURE, BUT PRODUCES STRONG IRRITATION OF URINARY TRACT. INCREASES THE ACTIVITY OF PEPSIN....TOXIC TO SOME CROPS... |
| RAIS Toxicity Values | 0.0045CALEPA0.0004 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| Customs code | 29241990 |
| Risk statements (R) | 36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 26-36/37-36 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P405-P501a-P305+P351+P338 |
| Hazardous substances data | 108-19-0(Hazardous Substances Data) |
Applications & Uses
Uses
1. Biuret is used in feed for ruminants, as feed additives as urea, like, but more safe than urea. 2. It is used as pharmaceutical intermediates, growth hormone, foaming agents, paints. 3. It is used for chemical analysis.
Uses
Analytical reagent, especially for proteins.
Uses
Biuret is used in protein assay. It is also used as Catalytic agent, Petrochemical additive. It is used in organic synthesis. Biuret (Carbamoylurea) was used as a source of dietary nitrogen in purified diets for steers.