1-Ethylpiperazine
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Basic information
- CAS
5308-25-8- Standard SMILES
CCN1CCNCC1- InChIKey
WGCYRFWNGRMRJA-UHFFFAOYSA-N- Molecular formula
- C6H14N2
- Average molar mass
- 114.19 g/mol
- Monoisotopic mass
- 114.11569845
Names & identifiers
- Preferred name
- 1-Ethylpiperazine
- IUPAC
- 1-ethylpiperazine
- English name
- 1-Ethylpiperazine
- Molecular formula
- C6H14N2
- Molecular weight
- 114.19
Names & synonyms
1-Ethylpiperazine5308-25-8N-EthylpiperazinePiperazine, 1-ethyl-EINECS 226-166-6UNII-6W2BW0V73G6W2BW0V73GNSC-607071-Ethyl-2,5-dihydropiperazineDTXSID8073346EC 226-166-6N-ETHYLPIPERAZINE [USP-RS]
Show more names
NEPRZ1-EthylperazineN-EthylpiperazinETHYLPIPERAZINE-NAKOS BBS-000036101-ethyl-piperazin1-ethvlpiperazineN-Alkylpiperazine
NSC 60707N-ETHYLPIPERAZINE (USP-RS)RefChem:75775DTXCID5041352InChI=1/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1HWGCYRFWNGRMRJA-UHFFFAOYSA-NN-ethyl piperazine1-ethyl-piperazine
Database identifiers
- CAS
5308-25-8- PubChem CID
- 79196
- DTXSID
DTXSID8073346- UNII
- 6W2BW0V73G
- EC Number
- 226-166-6
- Nikkaji
- J208.490B
Properties
Computed structural propertiesFilling in
- XLogP
- 0
- Topological polar surface area
- 15.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 57.5
Experimental & physicochemical properties
SpringerMaterials PropertiesRefractive index
Physicochemical properties
- Melting point
- -60 °C · -60 °C
- Boiling point
- 157 °C · 157 °C(lit.)
- Density
- 0.899 g/mL · 0.899 g/mL at 25 °C(lit.)
- vapor pressure
- 2.48 hPa · 2.48hPa at 20℃
- refractive index
- 20 · n20/D 1.469(lit.)
- Flash point
- 110 °F · 110 °F
- storage temp.
- 2 · 2-8°C
- solubility
- soluble
- form
- Liquid
- pka
- 9.27 · 9.27±0.10(Predicted)
- Specific Gravity
- 0.899 · 0.899
- color
- Clear colorless to yellow
- Water Solubility
- soluble
- Sensitive
- Air Sensitive
- BRN
- 102971 · 102971
- InChI
- 1S/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3
- InChIKey
- WGCYRFWNGRMRJA-UHFFFAOYSA-N
- SMILES
- CCN1CCNCC1
- LogP
- -0.1 at · -0.1 at 20℃
- CAS DataBase Reference
- 5308 · 5308-25-8(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 6 W2BW0V73G · 6W2BW0V73G
- NIST Chemistry Reference
- N-ethylpiperazine(5308-25-8)
- EPA Substance Registry System
- 1 · Piperazine, 1-ethyl- (5308-25-8)
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 2 · GHS02,GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 226 · H226-H302+H332-H314-H317-H335
- Precautionary statements
- 210 · P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
- target organs
- Respiratory system
- PPE
- Eyeshields, Gloves, type ABEK (EN14387) respirator filter
- Hazard Codes
- Xi,Hazard
- Risk Statements
- 36 · 36/37/38-10
- Safety Statements
- 26 · 26-36
- RIDADR
- 1993 · UN 1993 3/PG 3
- WGK Germany
- 1 · 1
- RTECS
- 815500 · TM0815500
- F
- 10 · 10-34
- HazardClass
- 3 · 3
- PackingGroup
- III
- HS Code
- 29335995 · 29335995
- Storage Class
- 3 · 3 - Flammable liquids
- Hazard Classifications
- 4 OralEye · Acute Tox. 4 OralEye Dam. 1Flam. Liq. 3Skin Corr. 1BSkin Sens. 1BSTOT SE 3
- REACH Registrations
- Active
- Limited Quantities
- 5 L · 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 275 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 12-11-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/31739
1-Ethylpiperazine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesFlam. Liq. 3 (100%)
Safety data
- F
- 10-34
- PPE
- Eyeshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 1
- rtecs
- TM0815500
- ridadr
- UN 1993 3/PG 3
- hs_code
- 29335995
- risk_code
- 36/37/38-10
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS05,GHS07
- hazard_code
- Xi,Hazard
- safety_code
- 26-36
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- III
- target organs
- Respiratory system
- Hazard statements
- H226-H302+H332-H314-H317-H335
- Limited Quantities
- 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralEye Dam. 1Flam. Liq. 3Skin Corr. 1BSkin Sens. 1BSTOT SE 3
- Precautionary statements
- P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Chemistry & industry
Applications
Uses1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.
Uses1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
484 records
Compound notes
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