Basic information
- CAS
5424-37-3- Standard SMILES
Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1.Cl.Cl- InChIKey
GKQYGRWQCWWSHN-UHFFFAOYSA-N- Molecular formula
- C21H22Cl2N6O
- Average molar mass
- 445.3 g/mol
- Monoisotopic mass
- 444.1232147
Names & identifiers
- Preferred name
- Aminoquinuride hydrochloride
- IUPAC
- 1,3-bis(4-amino-2-methylquinolin-6-yl)urea;dihydrochloride
- English name
- 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
- Molecular formula
- C21H22Cl2N6O
- Molecular weight
- 445.34498
Names & synonyms
Aminoquinuride dihydrochloride1,3-Bis(4-amino-2-methyl-6-quinolyl)urea dihydrochlorideAminoquinuride hydrochlorideDTXSID1045083P2YT71SUIUNSC-12155DTXCID9025083RefChem:915704226-566-05424-37-3SurfenSurfen dihydrochloride
Show more names
Surfen (NSC-12155)NSC-12155 (surfen hydrate)Aminokinuride dihydrochloride1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
Surfen (dihydrochloride)Aminoquincarbamide dihydrochloride1,3-bis(4-amino-2-methylquinolin-6-yl)urea dihydrochlorideAminochinuridAminoquinurid dihydrochloridAminoquinuride HClCAS-5424-37-3NCGC00013130-03
Database identifiers
- CAS
5424-37-3- PubChem CID
- 79472
- DTXSID
DTXSID1045083- ChEMBL
CHEMBL2132372- UNII
- P2YT71SUIU
- EC Number
- 226-566-0
Properties
Computed structural properties
- Topological polar surface area
- 119 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 30
- Formal charge
- 0
- Complexity
- 513
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Off-white to gray
- FDA UNII
- 2 YT71SUIU · P2YT71SUIU
Chemistry & industry
Applications
UsesSurfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
Suppliers18 total
奥夫仑医药（四川）有限公司17336178085 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
陕西缔都新材料有限公司029-63373950 17392216152 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海芮晖化工科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…