Basic information
- Standard SMILES
COCCN- InChIKey
ASUDFOJKTJLAIK-UHFFFAOYSA-N- Molecular formula
- C3H9NO
- Average molar mass
- 75.11 g/mol
- Monoisotopic mass
- 75.06841391
Names & identifiers
- Preferred name
- 2-Methoxyethylamine
- IUPAC
- 2-methoxyethanamine
- English name
- 2-Methoxyethylamine
- Molecular formula
- C3H9NO
- Molecular weight
- 75.11
Names & synonyms
2-Methoxyethylamine2-MethoxyethanamineEthanamine, 2-methoxy-METHOXYETHYLAMINEBRN 0741854EINECS 203-712-1UNII-743U9W3NIL743U9W3NILAI3-24230AI3-524722-methoxy-1-aminoethanen-(2-methoxyethyl)amine
Show more names
2-AMINOETHYL METHYL ETHERMethyl-PEG-amineCAS_109-85-32-methoxy-ethylamin2-methoxy-ethanaminRARECHEM AL BW 0200
CH3OCH2CH2NH2DTXSID1021908ASUDFOJKTJLAIK-UHFFFAOYSA-4-04-00-01411 (Beilstein Handbook Reference)2methoxyethanamine2Methoxy1ethanaminebetaMethoxyethylamine1Amino2methoxyethane
Database identifiers
- CAS
109-85-3- PubChem CID
- 8018
- DTXSID
DTXSID1021908- ChEMBL
CHEMBL4101550- UNII
- 743U9W3NIL
- EC Number
- 203-712-1
- Nikkaji
- J46.395G
Properties
Computed structural properties
- XLogP
- -0.9
- Topological polar surface area
- 35.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 5
- Formal charge
- 0
- Complexity
- 16.4
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Other Nitrogen Compounds
SpringerMaterials PropertiesCoriolis coupling
Boiling Point95 °C @760 [mm Hg]
Physical DescriptionClear colorless liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- -82 °C · -82 °C
- Boiling point
- 95 °C · 95 °C (lit.)
- Density
- 0.864 g/mL · 0.864 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.406(lit.)
- Flash point
- 49 °F · 49 °F
- storage temp.
- 30 °C · Store below +30°C.
- Water Solubility
- Completely miscible in water
- form
- clear liquid
- pka
- 9.89 · 9.89(at 10℃)
- color
- Colorless to Almost colorless
- PH
- 12 · 12 (100g/l, H2O, 20℃)
- explosive limit
- 3 · 3-16.10%(V)
- BRN
- 741854 · 741854
- Henry's Law Constant
- 2.5 · 2.5×101 mol/(m3Pa) at 25℃, Cabani et al. (1978)
- InChI
- 1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3
- InChIKey
- ASUDFOJKTJLAIK-UHFFFAOYSA-N
- SMILES
- COCCN
- CAS DataBase Reference
- 109 · 109-85-3(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 743 U9W3NIL · 743U9W3NIL
- EPA Substance Registry System
- 2 · Ethanamine, 2-methoxy- (109-85-3)
- UNSPSC Code
- 12352116 · 12352116
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02,GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 225 · H225-H302+H332-H314
- Precautionary statements
- 210 · P210-P280-P301+P312+P330-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310
- PPE
- Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
- Hazard Codes
- F,C
- Risk Statements
- 11 · 11-34
- Safety Statements
- 16 · 16-26-36/37/39-45
- RIDADR
- 2733 · UN 2733 3/PG 2
- WGK Germany
- 3 · 3
- RTECS
- 8750000 · KR8750000
- Autoignition Temperature
- 285 °C · 285 °C
- TSCA
- TSCA listed
- HazardClass
- 3 · 3
- PackingGroup
- II
- HS Code
- 29221990 · 29221990
- Storage Class
- 3 · 3 - Flammable liquids
- Hazard Classifications
- 4 InhalationAcute · Acute Tox. 4 InhalationAcute Tox. 4 OralEye Dam. 1Flam. Liq. 2Skin Corr. 1B
- Toxicity
- 50 orally · LD50 orally in Rabbit: 1570 mg/kg
- Limited Quantities
- 1 L · 1.0 L (0.3 gallon) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
Safety & regulation
GHS classification
GHS Classification
Danger
H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 156 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information2-Methoxyethylamine: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
A severe eye irritant; Causes muscle weakness, tremor, ataxia, dyspnea, and cyanosis in oral lethal-dose studies of rats and mice; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See Ethanolamine.
Hazard Classes and CategoriesFlam. Liq. 2 (100%)
Safety & protection
Protective Action Criteria (PAC)
1.3 [mg/m3]
14 [mg/m3]
87 [mg/m3]
Toxicology
Adverse EffectsDermatotoxin - Skin burns.
Safety data
- PPE
- Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- KR8750000
- ridadr
- UN 2733 3/PG 2
- hs_code
- 29221990
- Toxicity
- LD50 orally in Rabbit: 1570 mg/kg
- risk_code
- 11-34
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS05,GHS07
- hazard_code
- F,C
- safety_code
- 16-26-36/37/39-45
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- II
- Hazard statements
- H225-H302+H332-H314
- Limited Quantities
- 1.0 L (0.3 gallon) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
- Hazard Classifications
- Acute Tox. 4 InhalationAcute Tox. 4 OralEye Dam. 1Flam. Liq. 2Skin Corr. 1B
- Autoignition Temperature
- 285 °C
- Precautionary statements
- P210-P280-P301+P312+P330-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationEthanamine, 2-methoxy-: ACTIVE
Applications
Uses2-Methoxyethylamine is used as a reagent in the preparation of lipid-like materials for delivery of RNAi therapeutics.
General DescriptionKinetics of reaction of 2-methoxyethylamine with guanosine 5′-phospho-2-methylimidazolide (2-MeImpG) was studied.
Upstream & downstream products
Upstream raw materials
Downstream products
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