6-Methoxy-3-pyridinylamine

HCID 81121CAS 6628-77-9
Substructure searchFind similar structures

Basic information

Standard SMILES
COc1ccc(N)cn1
InChIKey
UUVDJIWRSIJEBS-UHFFFAOYSA-N
Molecular formula
C6H8N2O
Average molar mass
124.14 g/mol
Monoisotopic mass
124.06366288

Names & identifiers

Preferred name
6-Methoxy-3-pyridinylamine
IUPAC
6-methoxypyridin-3-amine
English name
5-Amino-2-methoxypyridine
Molecular formula
C6H8N2O
Molecular weight
124.14

Names & synonyms

5-Amino-2-methoxypyridine6628-77-92-Methoxy-5-aminopyridine3-Pyridinamine, 6-methoxy-Pyridine, 5-amino-2-methoxy-6-Methoxy-3-pyridylamine6-methoxy-3-pyridinylamine6-METHOXY-3-PYRIDINAMINE6-methoxy-3-aminopyridineEINECS 229-612-8ATT39K5F0CNSC 59708
Show more names
6-METHOXYPYRIDIN-3-AMINE5-Amino-2-methoxy3-Amino-6-methoxypyOTAVA-BB BB70204100796-methoxy-3-pyridinamin6-methoxypyridin-3-amin2-Methoxypyridin-5-amine5-amino-2-methoxy-pyridin
BRN 01151553-AMINO-6-METHOXYPYRIDINENSC-59708DTXSID202164845-22-11-00408 (Beilstein Handbook Reference)(2-METHOXYPYRIDIN-5-YL)AMINERefChem:543653DTXCID20138975

Database identifiers

CAS
6628-77-9
PubChem CID
81121
DTXSID
DTXSID20216484
ChEBI
CHEBI:194950
UNII
ATT39K5F0C
EC Number
229-612-8
Nikkaji
J265.561F

Properties

Computed structural properties

XLogP
1
Topological polar surface area
48.1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
1
Heavy atoms
9

Experimental & physicochemical properties

Kovats Retention Index · 2 items

1226

2165

Physicochemical properties

Melting point
29 · 29-31 °C (lit.)
Boiling point
85 · 85-90 °C/1 mmHg (lit.)
Density
1.575 · 1.575
refractive index
20 · n20/D 1.575(lit.)
Flash point
230 °F · >230 °F
storage temp.
2 · 2-8°C

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (97.9%)

Safety data

PPE
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk
3
rtecs
US1836000
hs_code
29339900
risk_code
22-36/37/38
Signal word
Warning

Chemistry & industry

Applications · 1 item

Uses5-Amino-2-methoxypyridine is used as a reagent in the synthesis of a novel series of thienopyrimidines as highly potent and selective PI3K inhibitors. 5-Amino-2-methoxypyridine is also used to synthesize EMPA (E521550); a novel high-affinity selective antagonist for the OX2 receptor.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

Additional notes

DefinitionChEBI: 6-Methoxypyridin-3-amine is an aminopyridine.

Related reactions

2,533 records
New reaction record

Linked notes

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