1-Amino-4-methylpiperazine

HCID 81349
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Basic information

CAS
6928-85-4
Standard SMILES
CN1CCN(N)CC1
InChIKey
RJWLLQWLBMJCFD-UHFFFAOYSA-N
Molecular formula
C5H13N3
Average molar mass
115.18 g/mol
Monoisotopic mass
115.11094742

Overview

1-Amino-4-methylpiperazine is an organic molecular entity.

Names & identifiers

Preferred name
1-Amino-4-methylpiperazine
IUPAC
4-methylpiperazin-1-amine
English name
1-Amino-4-methylpiperazine
Molecular formula
C5H13N3
Molecular weight
115.18

Names & synonyms

1-Amino-4-methylpiperazine6928-85-44-Methyl-1-piperazinamineDTXSID3057808J5GBT1LFT21-amino 4-methylpiperazineNSC-80649DTXCID1031597RefChem:74882230-053-74-Methylpiperazin-1-amine1-Piperazinamine, 4-methyl-
Show more names
AMPRZ1A4MP1-Amino-4-MethylTIMTEC-BB SBB004299AMINOMETHYLPIPERAZINELABOTEST-BB LT000050821-piperazinylmethanamine1-AMINO-4-METHYLPIERAZINE
1-methyl-4-aminopiperazine1-Methyl-4-aminopierazine4-methyl-1-aminopiperazineUNII-J5GBT1LFT2MFCD000061544-amino-1-methylpiperazinen-amino-n'-methylpiperazine4-methylpiperazin-1-ylamine

Database identifiers

CAS
6928-85-4
PubChem CID
81349
DTXSID
DTXSID3057808
ChEMBL
CHEMBL3560514
ChEBI
CHEBI:230450
UNII
J5GBT1LFT2
EC Number
230-053-7
Nikkaji
J38.964A

Properties

Computed structural properties

XLogP
-1.1
Topological polar surface area
32.5 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
0
Heavy atoms
8

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Piperazines
Physical DescriptionColorless liquid; [Sigma-Aldrich MSDS]

Physicochemical properties

Boiling point
172 · 172-175 °C (lit.)
Density
0.957 g/mL · 0.957 g/mL at 25 °C (lit.)
vapor pressure
1.29 hPa · 1.29hPa at 25℃
refractive index
1.4835 · 1.4835-1.4855
Flash point
62 °C · 62 °C
storage temp.
Keep in dark place,Inert atmosphere,Room temperature

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (32%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 125 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Chemical: 1-Piperazinamine, 4-methyl-

Status: Active Update: 16-11-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/19774

1-Amino-4-methylpiperazine: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA skin and strong eye irritant; Harmful by ingestion, inhalation, and skin absorption; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (32%)

Safety data

PPE
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk
3
ridadr
2733
hs_code
29335995
risk_code
36/37/38-20/21/22
Signal word
Warning

Chemistry & industry

Applications · 1 item

Uses1-Amino-4-methylpiperazine has been used:in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenolas a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-aminesynthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-aminesynthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-aminesynthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-aminesynthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-aminesynthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine

Preparation methods · 1 item

Preparation1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.

Upstream & downstream products

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Related reactions

71 records
New reaction record

Compound notes

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