Basic information
- CAS
7087-68-5- Standard SMILES
CCN(C(C)C)C(C)C- InChIKey
JGFZNNIVVJXRND-UHFFFAOYSA-N- Molecular formula
- C8H19N
- Average molar mass
- 129.24 g/mol
- Monoisotopic mass
- 129.15174961
Names & identifiers
- Preferred name
- Diisopropylethylamine
- IUPAC
- N-ethyl-N-propan-2-ylpropan-2-amine
- English name
- N,N-Diisopropylethylamine
- Molecular formula
- C8H19N
- Molecular weight
- 129.24
Names & synonyms
N,N-Diisopropylethylamine7087-68-5EthyldiisopropylamineDiisopropylethylamineN-EthyldiisopropylaminedieaDIPEAHunig's Base2-Propanamine, N-ethyl-N-(1-methylethyl)-1,1'-Dimethyltriethylamine5SIQ15721LNSC-147491
Show more names
DIEPAi-Pr2NEt
DTXSID8064561RefChem:161220DTXCID3046829230-392-0N-ethyl-N-isopropylpropan-2-amineethylbis(propan-2-yl)amineN-Ethyl-N,N-diisopropylamineN-ethyl-N-propan-2-ylpropan-2-amine
Database identifiers
- CAS
7087-68-5- PubChem CID
- 81531
- DTXSID
DTXSID8064561- ChEBI
CHEBI:193590- UNII
- 5SIQ15721L
- EC Number
- 230-392-0
- Nikkaji
- J108.742H
Properties
Computed structural properties
- XLogP
- 2.2
- Topological polar surface area
- 3.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 3
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 59
Experimental & physicochemical properties
Density0.742 @25 °C
Boiling Point126.5 °C @760 [mm Hg]
Vapor Pressure12.0 [mmHg]
Physical DescriptionClear colorless liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- -50 °C · <-50 °C (lit.)
- Boiling point
- 127 °C · 127 °C (lit.)
- Density
- 0.742 g/mL · 0.742 g/mL at 25 °C (lit.)
- vapor pressure
- 31 mmHg · 31 mmHg ( 37.7 °C)
- refractive index
- 20 · n20/D 1.457
- Flash point
- 6 °C · 6 °C
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- miscible
- form
- Liquid
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2527) of reports.
Danger
H225 (97.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]；H302 (92.3%): Harmful if swallowed [Warning Acute toxicity, oral]；H318 (96.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H331 (91.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H335 (91.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2527 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 2527 reports by companies.；There are 27 notifications provided by 2526 of 2527 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: 2-Propanamine, N-ethyl-N-(1-methylethyl)-
2-Propanamine, N-ethyl-N-(1-methylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanamine, N-ethyl-N-(1-methylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 01-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13609；Status: Active Update: 24-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28157
2-Propanamine, N-ethyl-N-(1-methylethyl)-: Does not have an individual approval but may be used under an appropriate group standard
Chemistry & industry
Uses & manufacturing
Uses
Used to make and/or formulate industrial products; [BASF MSDS]
Synthetic Polymer MALDI Matrix Compounds
U.S. Production2022: 50,000 - <250,000 lb；2021: 50,000 - <250,000 lb；2020: 50,000 - <250,000 lb
Industry UsesIntermediate
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
2-Propanamine, N-ethyl-N-(1-methylethyl)-: ACTIVE
Applications
DescriptionN,N-Diisopropylethylamine is also known as Hunig's base and abbreviated as DIPEA or DIEA, It is a sterically hindered amine and an organic compound. The colourless liquid was named as Hung’s base after Siegfried Hunig, a German chemist. It is noteworthy that the compound is commercially available.In organic chemistry, N,N-Diisopropylethylamine is used as a base. Since the nitrogen centre is isolated by an ethyl group and the two isopropyl groups, It can bind to protons. The compound is, therefore, a base similar to 2,2,6,6-tetramethylpiperidine, but a poor nucleophile, a blend of properties that makes it valuable as an organic reagent.
UsesN,N-Diisopropylethylamine is used as a base in organic reactions. Used in the preparation of (-)Gambierol a marine polycyclic ether toxin. It is also used in the synthesis of potent inhibitors of human brain memapsin, a key effector in the progression of Alzheimer’s disease.
General DescriptionN-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.
Preparation methods
PreparationN,N-Diisopropylethylamine is used as a non-nucleophilic base in organic synthesis. It is prepared by the alkylation of diisopropylamine with diethyl sulphate. DIPEA can then be purified through distillation from potassium hydroxide if necessary.
Related reactions
107,525 records
Compound notes
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