CAS 7143-01-3 Methanesulfonic anhydride (HCID 81560)

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Basic information

CAS: 7143-01-3
Standard SMILES: CS(=O)(=O)OS(C)(=O)=O
InChIKey: IZDROVVXIHRYMH-UHFFFAOYSA-N
Molecular formula: C2H6O5S2
Average molar mass: 174.2 g/mol
Monoisotopic mass: 173.96566529

Names & identifiers

Preferred name: Methanesulfonic anhydride
IUPAC: methylsulfonyl methanesulfonate
English name: Methanesulfonic anhydride
Molecular formula: C2H6O5S2
Molecular weight: 174.19

Names & synonyms

Methanesulfonic anhydrideMethanesulphonic anhydridemethanesulfonyl methanesulfonateMethanesulfonic acid, 1,1'-anhydrideJ492U7J4PBNSC-65906DTXSID70864010EINECS 230-442-1NSC 65906RefChem:156942DTXCID80812567IZDROVVXIHRYMH-UHFFFAOYSA-N

Show more names

7143/1/3Methanesulfonyl anhydrideSKL265

7143-01-3methylsulfonyl methanesulfonateMethanesulfonic acid, anhydrideMesyl anhydrideMFCD00007556Mesic anhydridemethanesulfonicanhydridemethylsulfonic anhydride

Database identifiers

CAS: 7143-01-3
PubChem CID: 81560
DTXSID: DTXSID70864010
UNII: J492U7J4PB
EC Number: 230-442-1
Nikkaji: J24.127J

Properties

Computed structural properties

XLogP: -0.8
Topological polar surface area: 94.3 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 5
Rotatable bonds: 2
Heavy atoms: 9
Formal charge: 0
Complexity: 227

Physicochemical properties

Melting point: 64 · 64-67 °C (lit.)
Boiling point: 125 °C/4 · 125 °C/4 mmHg (lit.)
Density: 1 · 1,36 g/cm3
vapor density: 3.3 · 3.3 (vs air)
refractive index: 1.53 · 1.5300 (estimate)
Flash point: 125 °C/4mm · 125°C/4mm
storage temp.: 20 °C · Store at <= 20°C.
solubility: Soluble in organic solvents.
form: Powder, Crystals and/or Chunks
color: White to light brown to gray
Sensitive: Moisture Sensitive
BRN: 972316 · 972316
InChI: 1S/C2H6O5S2/c1-8(3,4)7-9(2,5)6/h1-2H3
InChIKey: IZDROVVXIHRYMH-UHFFFAOYSA-N
SMILES: CS(=O)(=O)OS(C)(=O)=O
CAS DataBase Reference: 7143 · 7143-01-3(CAS DataBase Reference)

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 64 reports by companies from 9 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 3 items

Chemical: Methanesulfonic acid, anhydride

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/19506

Methanesulphonic anhydride: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Corr. 1 (100%)

Safety data

F: 3-10
PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
wgk: 3
tsca: TSCA listed
ridadr: UN 3261 8/PG 2
hs_code: 29041000
risk_code: 14-35
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationMethanesulfonic acid, 1,1'-anhydride: ACTIVE

Applications · 1 item

UsesMethanesulfonic anhydride is used to prepare methylsulfonyl esters called as mesylates. It finds application in the reaction of aromatic alkylation. It reacts with dimethylsulfoxide to get sulfoxonium complex, which is a useful oxidizing agent.

Preparation methods · 1 item

PreparationMethanesulfonic anhydride may be prepared by the dehydration of methanesulfonic acid with phosphorus pentoxide.P2O5 + 6 CH3SO3H → 3 (CH3SO2)2O + 2 H3PO4Methanesulfonic anhydride can be purified by distillation under vacuum (distillation of a solid) or by recrystallized from Methyl tert-butyl ether/toluene.