CAS 7397-62-8 Butyl Glycolate (HCID 81882)

Overview

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Butyl Glycolate...

Names & identifiers

Preferred name: Butyl Glycolate
IUPAC: butyl 2-hydroxyacetate
English name: Butyl hydroxyacetate
Molecular formula: C6H12O3
Molecular weight: 132.16

Names & synonyms

Butyl glycolatebutyl 2-hydroxyacetate7397-62-8Butyl hydroxyacetateAcetic acid, hydroxy-, butyl estern-butyl glycolateDTXSID60447253H5QAS0HZXAcetic acid, 2-hydroxy-, butyl esterUNII-3H5QAS0HZXGlycolic acid, butyl esterEINECS 230-991-7

Show more names

Polysolvan OButyl hydroxyacetate ISO 9001：2015 REACHPolysolvan 0butyl glycollateButhyl Glycolate

BUTOXYCARBONYLMETHANOLAI3-07975DTXCID4024725EC 230-991-7RefChem:122255BUTYL GLYCOLATE [INCI]230-991-7VFGRALUHHHDIQI-UHFFFAOYSA-N

Database identifiers

CAS: 7397-62-8
PubChem CID: 81882
DTXSID: DTXSID6044725
ChEMBL: CHEMBL3184386
UNII: 3H5QAS0HZX
EC Number: 230-991-7
Nikkaji: J39.924H

Properties

Computed structural properties

XLogP: 0.7
Topological polar surface area: 46.5 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 3
Rotatable bonds: 5
Heavy atoms: 9
Formal charge: 0
Complexity: 80.4

Experimental & physicochemical properties

CosmeticsCosmetic ingredients (Butyl Glycolate) -> CIR (Cosmetic Ingredient Review)

SpringerMaterials PropertiesSurface tension

Physicochemical properties

Boiling point: 187 · 187-190 °C(lit.)
Density: 1.019 g/mL · 1.019 g/mL at 20 °C(lit.)
vapor pressure: 1.3 hPa · 1.3hPa at 20℃
refractive index: 20 · n20/D 1.427
Flash point: 74 °C · 74 °C
storage temp.: 2 · 2-8°C
pka: 12.99 · 12.99±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
Water Solubility: 46 g/L · 46g/L at 20℃
BRN: 1749477 · 1749477
Cosmetics Ingredients Functions: SKIN CONDITIONING
Cosmetic Ingredient Review (CIR): Butyl hydroxyacetate (7397-62-8)
InChI: InChI=1S/C6H12O3/c1-2-3-4-9-6(8)5-7/h7H,2-5H2,1H3
InChIKey: VFGRALUHHHDIQI-UHFFFAOYSA-N
SMILES: C(OCCCC)(=O)CO
LogP: 0.38 at · 0.38 at 25℃
CAS DataBase Reference: 7397 · 7397-62-8(CAS DataBase Reference)
FDA UNII: 3 H5QAS0HZX · 3H5QAS0HZX
NIST Chemistry Reference: Butyl glycolate(7397-62-8)
EPA Substance Registry System: Acetic acid, hydroxy-, butyl ester (7397-62-8)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS08
Signal word: Danger
Hazard statements: 318 · H318-H361
Precautionary statements: 201 · P201-P280-P305+P351+P338+P310-P308+P313
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xn
Risk Statements: 63 · 63-41
Safety Statements: 23 · 23-24/25-36/37/39-26
RIDADR: 1993 · NA 1993 / PGIII
WGK Germany: 1 · 1
TSCA: TSCA listed
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 1 Repr · Eye Dam. 1Repr. 2
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 0.2% (6 of 2726) of reports.

Danger

H318 (99.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement)

Aggregated GHS information provided per 2726 reports by companies from 12 notifications to the ECHA C&L Inventory.

Warning

Hazard information

Regulatory Information · 3 items

Chemical: Acetic acid, hydroxy-, butyl ester

Status: Active Update: 17-01-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/23612

Acetic acid, hydroxy-, butyl ester: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and Categories · 2 items

Eye Dam. 1 (99.8%)

Flammable liquids - Category 4

Toxicology

Toxicity Summary · 2 items

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Butyl Glycolate...

Safe for use in cosmetics, with qualifications

Safety data

PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 1
tsca: TSCA listed
ridadr: NA 1993 / PGIII
risk_code: 63-41
Signal word: Danger
Symbol(GHS): GHS05,GHS08
hazard_code: Xn
safety_code: 23-24/25-36/37/39-26
Storage Class: 10 - Combustible liquids
Hazard statements: H318-H361
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Repr. 2
Precautionary statements: P201-P280-P305+P351+P338+P310-P308+P313

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: Butyl Glycolate

General Manufacturing InformationAcetic acid, 2-hydroxy-, butyl ester: ACTIVE

Applications · 2 items

UsesButyl glycolate may be used in the preparation of N-(α-hydroxyacetyl)-(S)-isoleucine. n-Butyl glycolate is used primarily as a varnish additive, valued because of its low volatility. Trade names include PolysolvanO (Hoechst) and GB-Ester (Wacker). It confers smooth spreading properties and high gloss on nitrocellulose varnish. For acetyl cellulose, it is effective as a blush inhibitor under conditions of high humidity. Due to its good blending properties, n-butyl glycolate is also used as an additive in alkyd resins and oil-based paints.

General DescriptionButyl glycolate is a glycolic acid derivative.