N-Trimethylsilyl-N-methylacetamide (HCID 81953)

Names & identifiers

Preferred name: N-Trimethylsilyl-N-methylacetamide
IUPAC: N-methyl-N-trimethylsilylacetamide
English name: N-Methyl-N-(trimethylsilyl)acetamide
Molecular formula: C6H15NOSi
Molecular weight: 145.27

Names & synonyms

N-Methyl-N-(trimethylsilyl)acetamide7449-74-3Acetamide, N-methyl-N-(trimethylsilyl)-N-Trimethylsilyl-N-methylacetamideW0IWF6UKW5EINECS 231-217-0NSC 142435NSC-142435DTXSID0064707RefChem:831201DTXCID2047694231-217-0

Show more names

MOUSE ALBUMIN[TriMethylsilylating Agent]N-Methyl-N-(trimethylsilyl)amideN-Methyl-N-trimethylsilylacetaminen-methyl-n-(trimethylsilyl)-acetamidAcetamide,N-methyl-N-(trimethylsilyl)-

N-Methyl-N-trimethylsilylacetamideN-Methyl-N-trimethylsilyacetamideN-Methyl-N-TMS-acetamideMFCD00040758N-Methylacetamide, TMS derivatives11925N-Methyl-N-trimethylsilylacetamide (>85%)N-Trimethylsilyl-N-methylacetamide; NSC 142435

Database identifiers

CAS: 7449-74-3
PubChem CID: 81953
DTXSID: DTXSID0064707
UNII: W0IWF6UKW5
EC Number: 231-217-0
Nikkaji: J208.694H

Properties

Computed structural properties

Topological polar surface area: 20.3 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 1
Heavy atoms: 9
Formal charge: 0
Complexity: 117

Experimental & physicochemical properties

SpringerMaterials Properties29Si nuclear magnetic resonance spectrum

Physicochemical properties

Boiling point: 159 · 159-161 °C(lit.)
Density: 0.904 g/mL · 0.904 g/mL at 20 °C(lit.)
refractive index: 20 · n20/D 1.439
Flash point: 48 °C · 48 °C
storage temp.: -20 °C · -20°C
form: lyophilized powder
pka: -0.11 · -0.11±0.70(Predicted)
color: Clear light yellow
Specific Gravity: 0.906 · 0.906
Sensitive: Moisture Sensitive
BRN: 506975 · 506975
InChI: InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
InChIKey: QHUOBLDKFGCVCG-UHFFFAOYSA-N
SMILES: C(N(C)[Si](C)(C)C)(=O)C
CAS DataBase Reference: 7449 · 7449-74-3(CAS DataBase Reference)
FDA UNII: 0 IWF6UKW5 · W0IWF6UKW5
NIST Chemistry Reference: Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System: Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)
UNSPSC Code: 12000000 · 12000000
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS02,GHS07
Signal word: Warning
Hazard statements: 314 · H314-H315-H319-H335-H226
Precautionary statements: 261 · P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501
PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi
Risk Statements: 10 · 10-36/37/38
Safety Statements: 37 · 37/39-16
RIDADR: 1993 · UN 1993 3/PG 3
WGK Germany: 3 · 3
F: 10 · 10-21
TSCA: TSCA listed
HazardClass: 3 · 3
PackingGroup: III
HS Code: 29319090 · 29319090
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 3 · Flam. Liq. 3
REACH Registrations: Active
Limited Quantities: 5 L · 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 5.9% (1 of 17) of reports.

Danger

H226 (94.1%): Flammable liquid and vapor [Warning Flammable liquids]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 17 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

Chemical: Acetamide, N-methyl-N-(trimethylsilyl)-

Status: Active Update: 13-05-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33411

Hazard Classes and CategoriesFlam. Liq. 3 (94.1%)

Safety data

F: 10-21
PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 3
tsca: TSCA listed
ridadr: UN 1993 3/PG 3
hs_code: 29319090
risk_code: 10-36/37/38
Signal word: Warning
Symbol(GHS): GHS05,GHS02,GHS07
hazard_code: Xi
safety_code: 37/39-16
hazard_class: 3
Storage Class: 3 - Flammable liquids
packing_group: III
Hazard statements: H314-H315-H319-H335-H226
Limited Quantities: 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
REACH Registrations: Active
Hazard Classifications: Flam. Liq. 3
Precautionary statements: P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationAcetamide, N-methyl-N-(trimethylsilyl)-: ACTIVE

Applications · 2 items

UsesN-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following: Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique. Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

General DescriptionN-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).