| GHS classification | DangerH315: Causes skin irritation [Warning Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H361fd: Suspected of damaging fertilitySuspected of damaging the unborn child [Warning Reproductive toxicity]H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P203, P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement) |
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| Regulatory information | Hazard Traits - Respiratory ToxicityAuthoritative List - EC Annex VI Resp. Sens. - Cat. 1Report - if used as a fragrance or flavor ingredient |
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| FDA requirements | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392). |
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| NIOSH Recommendations | Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m. |
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| Hazard Classes and Categories | Reproductive toxicity - category 2Eye irritation - category 2Skin irritation - category 2Respiratory sensitisation - category 1Hazardous to the aquatic environment (chronic) - category 3Skin sensitisation - category 1Repr. 2Skin Irrit. 2Eye Irrit. 2Resp. Sens. 1Skin Sens. 1Aquatic Chronic 3 |
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| Hazardous Reactivities and Incompatibilities | Water [Note: Slightly hygroscopic (i.e., absorbs moisture from the air)]. |
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| Disposal methods | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Preventive Measures | If material not on fire and not involved in fire: Keep sparks, flames, and othersources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /Piperazine/Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing. /Piperazine/The worker should immediately wash the skin when it becomes contaminated.Work clothing that becomes wet or significantly contaminated should be removed and replaced.Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. |
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| Threshold Limit Values (TLV) | 8 hr Time Weighted Avg (TWA): 5 mg/cu m.Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. |
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| Personal Protective Equipment (PPE) | Wear appropriate personal protective clothing to prevent skin contact.Wear appropriate eye protection to prevent eye contact.Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substancethis is irrespective of the recommendation involving the wearing of eye protection.Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] |
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| Interactions | IN ISOLATED FROG & RABBIT HEARTS PIPERAZINE PRODUCED BIPHASIC EFFECT WITH INITIAL NEG INOTROPIC ACTION FOLLOWED BY POS INOTROPIC ACTION. FORMER PHASE WAS ANTAGONIZED BY ATROPINE, HEXAMETHONIUM & DIGOXIN. DIRECT ACTION ON THE HEART IS SUGGESTED. /PIPERAZINE HYDROGEN CHLORIDE/ |
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| Human Toxicity Excerpts | ... SIDE EFFECTS ... INCL HEADACHES, NAUSEA, VOMITING, DIARRHEA, LETHARGY, TREMOR, INCOORDINATION, MUSCULAR WEAKNESS ... & VAGUE OCULAR DISTURBANCES. /PIPERAZINE SALTS/LOSS OF CONSCIOUSNESS, DYSARTHRIA, APRAXIA, CLONIC SPASMS, TREMOR, MUSCULAR WEAKNESS, DROPPING OF OBJECTS, INABILITY TO THINK CLEARLY &/OR HALLUCINATIONS SEEN IN 35 YR OLD PT WITH TERMINAL RENAL FAILURE TAKING 30 MG PIPERAZINE HEXAHYDRATE/KG BODY WT/DAY FOR 10 DAYS. /PIPERAZINE HEXAHYDRATE/SEVERE ILLNESS OCCURRED IN A 25 YR OLD WOMAN AFTER ADMIN OF PIPERAZINE ON 2 SEPARATE OCCASIONS. EVIDENCE FAVORS A HYPERSENSITIVITY MECHANISM RATHER THAN A DIRECT TOXIC EFFECT OF DRUG OR ITS METABOLITES. /PIPERAZINE/ACUTE HUMAN EXPOSURES HAVE RESULTED IN MILD TO MODERATE SKIN BURNS & SENSITIZATION. MILD TO MODERATE ASTHMA HAS BEEN ASSOCIATED WITH INHALATION OF DUST. |
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| Non-Human Toxicity Excerpts | EYE CONTACT, MARKED PAIN AND MODERATE EYE IRRITATION WHICH HEALS IN 2 DAYS WITH NO CORNEAL INJURY. SKIN CONTACT VERY SLIGHT IRRITATION.VOMITING & DIARRHEA IS OCCASIONALLY REPORTED IN CATS & DOGS ESPECIALLY IF OVERDOSED. /ORAL ADMIN/IN ISOLATED FROG & RABBIT HEARTS PIPERAZINE PRODUCED BIPHASIC EFFECT WITH INITIAL NEG INOTROPIC ACTION FOLLOWED BY POS INOTROPIC ACTION. FORMER PHASE WAS ANTAGONIZED BY ATROPINE, HEXAMETHONIUM & DIGOXIN. DIRECT ACTION ON HEART IS SUGGESTED. /PIPERAZINE/ |
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| Non-Human Toxicity Values | LD50 Rat oral 4,900 mg/kg |
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| Risk statements (R) | 36/37/38-42/43 |
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| Signal word | Danger |
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| GHS pictogram | GHS08 |
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| Safety statements (S) | 22-26-36/37/39-45 |
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| GHS hazard statements | H319-H412-H317-H334-H315-H361fd |
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| GHS precautionary statements | P261-P285-P304+P341-P342+P311-P501-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P273-P501 |
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