Basic information
- CAS
10424-65-4- Standard SMILES
C[N+](C)(C)C.O.O.O.O.O.[OH-]- InChIKey
MYXKPFMQWULLOH-UHFFFAOYSA-M- Molecular formula
- C4H12N.5H2O.HO
- Average molar mass
- 181.23 g/mol
- Monoisotopic mass
- 181.15253746
Names & identifiers
- Preferred name
- Tetramethylammonium Hydroxide Pentahydrate
- IUPAC
- tetramethylazanium;hydroxide;pentahydrate
- English name
- Tetramethylammonium hydroxide pentahydrate
- Molecular formula
- C4H23NO6
- Molecular weight
- 181.23
Names & synonyms
Tetramethylammonium hydroxide pentahydrate10424-65-4B2HKT2LCKQMethanaminium, N,N,N-trimethyl-, hydroxide, pentahydrateDTXSID9065073Methanaminium, N,N,N-trimethyl-, hydroxide, hydrate (1:1:5)tetramethyl ammonium hydroxide pentahydrateRefChem:188769DTXCID4032873629-762-8MFCD00149566tetramethylazanium;hydroxide;pentahydrate
Show more names
etramethylammonium Hydroxide PentahydrateTMAH PentahydrateTetramethyl ammoniumhydroxid pentahydrateetramethylammonium HydroxideMYXKPFMQWULLOH-UHFFFAOYSA-MTETRAMETHYLAMM HYDROXIDE 5HYDmethanaminium,n,n,n-trimethylammonium hydroxide pentahydrateTETRAMETHYLAMMONIUM HYDROXIDE*PENTAHTetramethylammonium Hydroxide-D135 D2O
Tetramethylammonium hydroxide (pentahydrate)C4H23NO6UNII-B2HKT2LCKQAmmonium, tetramethyl-, hydroxide, pentahydrateSCHEMBL192128C4H22NO6AKOS016008551FT75544
Properties
Computed structural properties
- Topological polar surface area
- 6 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 19.1
Experimental & physicochemical properties
Chemical ClassesOther Classes -> Bases
Physical DescriptionColorless deliquescent solid; [Merck Index] White hygroscopic crystals; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 67 · 67-70 °C(lit.)
- Density
- 1.829 · 1.829
- vapor density
- 1.1 · 1.1 (vs air)
- vapor pressure
- 97 mm · 97 mm Hg ( 20 °C)
- storage temp.
- 0 · 0-6°C
- solubility
- soluble (2,200 g/l at 15 °C (59 °F))
- form
- Hygroscopic Crystals
- color
- White
- Odor
- Ammonia like
- PH
- (14 at ca.1,000 g/l at 20 °C (68 °F))
- explosive limit
- 36 % · 36%
- Water Solubility
- soluble
Safety & regulation
GHS classification
GHS Classification
Danger
H290 (27.7%): May be corrosive to metals [Warning Corrosive to Metals]
P234, P260, P262, P264, P270, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P390, P405, P406, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 83 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H301: Toxic if swallowed [Danger Acute toxicity, oral]
Hazard information
Regulatory Information
Chemical: Methanaminium, N,N,N-trimethyl-, hydroxide, pentahydrate
Methanaminium, N,N,N-trimethyl-, hydroxide, pentahydrate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Tetramethylammonium hydroxide and its pentahydrate: Human health tier II assessment
Hazards Summary
A very strong base that readily absorbs carbon dioxide from the air; [Merck Index] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May be fatal by ingestion; Toxic by skin absorption; Oral LD50 (rat) = 34-50 mg/kg; [Sigma-Aldrich MSDS] See Tetramethyl ammonium hydroxide.
Hazard Classes and Categories
Met. Corr. 1 (27.7%)
Acute toxicity (ingestion) - category 3
Safety & protection
Protective Action Criteria (PAC)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine or by non-nicotinic effects on postganglionic neurons are not included here nor are the nonspecific cholinergic agonists.
Applications
UsesTetramethylammonium hydroxide is organic base, it has very wide range of uses in the field of industrial research. Domestic tetramethylammonium hydroxide is mainly used as organic silicon products, such as the catalyst of synthesizing silicone oil, silicone rubber, silicone resin, although the amount is not big, but the yield and quality of the product is greatly affected. Foreign tetramethylammonium hydroxide is mainly used for polyester-based polymers, textiles, plastics, food, leather, wood processing, electroplating, and other microorganisms. At present, this product has came into the advanced technology areas, such as in printed circuit board manufacturing and microscopic sheets, it can be used as cleaning agent in integrated circuit and anisotropic etchant in semiconductor microfabrication technology of the Si-SiO2 interface. With the development of science and technology, the requirement of this type of chemical is increasing, the quality and quantity of tetramethylammonium hydroxide have put forward higher requirements. It can be used as additive of silicone rubber, methyl silicone oil and polarographic analysis reagents. In terms of organosilicone, it can be used as catalyst of dimethyl silicone oil, phenylmethyl silicone oil, a silicone oil diffusion pump, solvent-free silicone molding compound, silicone resin, silicone rubber or the like. In the analysis, it can be used as polarography agent, in the purification of the product it can be used as non-gray base to precipitate many metal elements, it can be used as silicon computer face brightener, cleaning agents and the like engraved touch in the production of organic silicon. The advantage of tetramethylammonium hydroxide as catalyst is that after the reaction when heat, it can decompose into gas and disappear, and it does not remain in the product.
UsesTetramethylammonium hydroxide pentahydrate has been used in a study to assess strains of Pseudomnas species by a single-step gas chromatographic characterization procedure. It has also been used in a study to investigate solid-state metal hydride batteries nickel oxyhydroxide-metal hydride and manganese dioxide-metal hydride.
Related reactions
41 records
Compound notes
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