Dichlone

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Call a physician.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder.

Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. Also, a good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. /1,4-Naphthoquinone/

Glycerol or silicone base protective skin cremes are recommended. Lanolin, Vaseline, or oil-based creams should not be used.

If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.

Avoid skin contact or breathing dust, spray mist.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Self-contained breathing apparatus, rubber gloves, hats, suits, and boots. (USCG, 1999)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Personnel protection: ... Wear appropriate chemical protective gloves, boots, and goggles.

Self-contained breathing apparatus ... hats, suits ... .

LC50 Asellus brevicaudus (Aquatic sowbug) 100 ug/L/96 hr; static /formulated product/

LC50 Asellus brevicaudus (Aquatic sowbug) 200 ug/L/48 hr; static /formulated product/

LC50 Palaemonetes kadiakensis (Grass shrimp) 450 ug/L/48 hr; static /formulated product/

LC50 Orconectes nais (Crayfish) 3200 ug/L/48 hr; static /formulated product/

For more Ecotoxicity Values (Complete) data for DICHLONE (26 total), please visit the HSDB record page.

TERRESTRIAL FATE: Soil adsorption studies utilizing soil thin layer chromatography, soil column leaching and soil drench tests have found dichlone to be relatively immobile in soil(1). Volatilization of dichlone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.02X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Dichlone is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.1X10-6 mm Hg(3). In a silt loam soil dissipation study (soil pH 6.4, temperature of 26 °C), loss of dichlone in moist soil followed first order kinetics with an observed rate constant of 0.7/day which corresponds to a half-life of about 1 day(4); in air-dried soil (pH 6.2), dissipation was much slower with 45 percent of initial dichlone remaining after 3 months(4). Results of degradation studies under fieldhouse conditions, utilizing both sterile and non-sterile tests, suggest that disappearance of dichlone in moist soil, freshwater and sewage is primarily abiotic in nature with some biotic involvement(5); in non-sterile samples of moist soil, sewage and fresh water, one-half of added dichlone disappeared in about 4, 3 and 4 days of incubation, respectively(5). The experimentally determined half-life of dichlone in water (pH 7, 29 °C) is 5 days(4), which suggests dichlone is disappearing in moist soil primarily due to aqueous hydrolysis(SRC).

TERRESTRIAL FATE: In a field test, the results of which were somewhat erratic due to lack of analytical sensitivity, dichlone applied to an apple orchard soil declined in concentration during the growing season and was not detected in the soil the following year. During the growing season, some dichlone was detected 4-6 inches below the surface(1).

AQUATIC FATE: Soil adsorption studies have found dichlone to be strongly adsorbed and relatively immobile in soil(1); therefore, dichlone is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 1.02X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of 2.65(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Results of degradation studies, utilizing both sterile and non-sterile tests, suggest that disappearance of dichlone in moist soil, freshwater and sewage is primarily abiotic in nature with some biotic involvement(7); in non-sterile samples of moist soil, sewage and fresh water, one-half of added dichlone disappeared in about 4, 3 and 4 days of incubation, respectively(7). The experimentally determined half-life of dichlone in water (pH 7, 29 °C) is 5 days(8). In solution, dichlone is reported to decompose slowly by light(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dichlone, which has a vapor pressure of 1.1X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dichlone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 12 days(SRC), calculated from its rate constant of 1.34X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Vapor-phase dichlone is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be about 320 days(SRC), calculated from its rate constant of 3.6X10-19 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Dichlone absorbs at wavelengths >290 nm(4) and therefore is expected to be susceptible to direct photolysis by sunlight(SRC). Particulate-phase dichlone may be removed from the air by wet or dry deposition(SRC).

In a pesticide residue screening program conducted in San Antonio, TX between 1989 and 1991 on 6970 produce samples collected from a food store, dichlone (at a detection limit of 0.5 ppm) was detected in the following: 1 celery sample (0.5% of all celery samples); celery was one of 81 commodities sampled in the program and dichlone was not reported as being detected in the other 80 commodities(1). Dichlone was reported as detected as part of the US Food and Drug Administration Pesticide Monitoring of Foods during fiscal years 1978-1982 (detection limit, concentrations, specific samples not reported)(2).

/OTHER TERRESTRIAL SPECIES/ Southern armyworm, Spodoptera eridania, larvae were provided ad libitum 0.002-0.25% w/w dichlone, 2,3-dichloro-1,4-naphthoquinone (CNQ). Larval mortality occurred in a time-and-dose dependent manner, with an LC17 of 0.01% and an LC50 of 0.26% CNQ at day-5. Extracts of larvae fed control, 0.01, and 0.25% CNQ diets for 5 days were assayed for antioxidant enzymes. While 0.01% CNQ had a mild effect, 0.25% CNQ profoundly increased levels of all antioxidant enzymes that were examined. The increases as compared to control were: 5.3-, 1.9-, 3.2-, 2.6-, 2.8-, and 3.5-fold higher for superoxide dismutase, catalase, glutathione transferase and its peroxidase activity, glutathione reductase and DT-diaphorase, respectively. At 0.01% CNQ, the thiobarbituric acid reactive substances (TBARS) were similar to the control group. However, despite the induction from 0.25% CNQ of all enzymes examined, the lipid peroxidation was not attenuated; the TBARS were 29.7% over the control value. High mortalities and CNQ-induced pathologies reflected in retarded growth, wasting syndrome, and diuresis clearly indicated that the insect sustained severe oxidant-induced injuries before appropriate defenses were fully mobilized. Thus, this quinone causes an oxidative stress in a model insect species analogous to that observed in mammalian species.

Dichlone has been shown to be immobile in silty clay loam using soil thin layer chromatography as well as in soil columns and in soil drench tests(1). In one field test in which 0.4 lb/acre of active compound was applied to the soil in an apple orchard, 0.7 ppm dichlone was detected at 4-6 inch depth during the growing season. However the analytic method lacked sensitivity and results were erratic. None of the chemical survived to the next growing season(2).

/SIGNS AND SYMPTOMS/ Occupational exposure of humans to dust of 2,3-dichloro-1,4-naphthoquinone in concentration of 0.7-6 mg/cu m caused specific symptoms, including eye irritation, tightness in the chest, burning in the nasal passages, dermatitis, and decrease in number of erythrocytes and SH-groups in the blood.

/SIGNS AND SYMPTOMS/ ...CNS depressant.

/OTHER TOXICITY INFORMATION/ Dichlone (3X10-5 to 1X10-3 molar) induced rapid loss of intracellular potassium from normal human erythrocytes, and leakage of potassium (+) varied with the fungicide and cell concentration. Dichlone also increased osmotic fragility and inhibited sodium(+)-potassium (+)-ATPase, which is associated with active ion transport. Hemolysis occurred at concentrations higher than those which resulted in potassium (+) loss. Hemoglobin loss appeared to be due primarily to osmotic swelling of the treated cells.

AEROBIC: Dichlone is considered to be resistant to degradation according to the biodegradability test of the Japanese Ministry of International Trade and Industry (MITI) which utilizes an inoculum derived from soil, surface water and sewage(1). Utilizing an initial dichlone concentration of 100 mg/L and a 14-day incubation period, the average BOD 0-5%(2).

AEROBIC: Chloranil and dichlone ... were investigated to assess persistence in four tropical ecosystems. Sterile and non-sterile samples of sewage water, fresh water, agricultural soil and sea water were incubated with 50 ug/ml of each fungicide under glasshouse conditions. ... Dichlone was less stable than chloranil in 3 of the 4 ecosystems tested. In non-sterile samples of soil, sewage and fresh water, one-half of added dichlone had disappeared in 4, 3 and 4 days of incubation at 30 °C, respectively; 23 weeks of incubation in sea water was necessary to degrade 50% of dichlone. The disappearance of both pesticides in the samples to be supported by biotic /degradation/ but chemical degradation was not precluded.

An estimated BCF of 3 was calculated for dichlone(SRC), using an estimated log Kow of 2.65(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Dichlone is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0008; Pesticide type: fungicide; Case Status: No products containing the pesticide are actively registered. Therefore, we are characterizing the case as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Dichlone; Data Call-in (DCI) Date(s): 10/05/90; AI Status: The active ingredient is no longer contained in any registered products. Thus, we characterize it as "cancelled."

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Dichlone is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.