Aminopropyltrimethoxysilane (HCID 83756)

Overview

reagent for making polymers; structure in first source

Names & identifiers

Preferred name: Aminopropyltrimethoxysilane
IUPAC: 3-trimethoxysilylpropan-1-amine
English name: 3-Aminopropyltrimethoxysilane
Molecular formula: C6H17NO3Si
Molecular weight: 179.29

Names & synonyms

13822-56-53-Aminopropyltrimethoxysilane(3-Aminopropyl)trimethoxysilane3-(Trimethoxysilyl)propylamine3-(Trimethoxysilyl)-1-propanamine1-Propanamine, 3-(trimethoxysilyl)-AminopropyltrimethoxysilaneSilane SC 3900Propylamine, 3-(trimethoxysilyl)-KBE 903SC 39007MRY0C9SB6

Show more names

APTMS3-(trimethoxysilyl)-1-propanaminγ-AminopropyltrimethoxysilaneA-1110CA0880KH0540

TMSPA cpdGENIOSIL GF 96NSC-838453-(aminopropyl)trimethoxysilaneRefChem:915703APS-3237-511-53-(Trimethoxysilyl)propan-1-amine

Database identifiers

CAS: 13822-56-5
PubChem CID: 83756
DTXSID: DTXSID0038833
UNII: 7MRY0C9SB6
EC Number: 237-511-5
Nikkaji: J209.066J

Properties

Computed structural properties

Topological polar surface area: 53.7 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 4
Rotatable bonds: 6
Heavy atoms: 11
Formal charge: 0
Complexity: 89.6

Experimental & physicochemical properties

Chemical ClassesMetals -> Metalloid Compounds (Silicon)

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physical Description · 2 items

Liquid

Clear to straw-colored liquid with an ammoniacal odor; [Gelest MSDS]

Physicochemical properties

Melting point: -60 °C · <-60°C
Boiling point: 91 · 91-92 °C15 mm Hg(lit.)
Density: 1.027 g/mL · 1.027 g/mL at 25 °C(lit.)
vapor pressure: 0 · 0-12790Pa at 20-25℃
refractive index: 20 · n20/D 1.424(lit.)
Flash point: 182 °F · 182 °F
storage temp.: 30 °C · Store below +30°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
pka: 10.61 · 10.61±0.10(Predicted)
color: Clear colorless
Specific Gravity: 1.027 · 1.027
PH: 9 · >9 (20g/l, H2O, 20℃)
Odor: Ammoniacal odor
Viscosity: 1.77 mm2/s · 1.77mm2/s
Water Solubility: reacts
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 7 · 7: reacts slowly with moisture/water
BRN: 2038118 · 2038118
Stability: Stable, but moisture sensitive. Incompatible with water, strong acids, strong oxidizing agents. Combustible.
Cosmetics Ingredients Functions: SKIN CONDITIONING - MISCELLANEOUS
InChI: 1S/C6H17NO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-7H2,1-3H3
InChIKey: SJECZPVISLOESU-UHFFFAOYSA-N
SMILES: CO[Si](CCCN)(OC)OC
LogP: -4 · -4--0.82 at 20℃
Indirect Additives used in Food Contact Substances: 3 · 3-(TRIMETHOXYSILYL)PROPYLAMINE
FDA 21 CFR: 175.105 · 175.105
CAS DataBase Reference: 13822 · 13822-56-5(CAS DataBase Reference)
FDA UNII: 7 MRY0C9SB6 · 7MRY0C9SB6
NIST Chemistry Reference: 1 · 1-Propanamine, 3-(trimethoxysilyl)-(13822-56-5)
EPA Substance Registry System: 1 · 1-Propanamine, 3-(trimethoxysilyl)- (13822-56-5)
UNSPSC Code: 12352103 · 12352103
NACRES: 23 · NA.23
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 315 · H315-H318
Precautionary statements: 264 · P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi,C
Risk Statements: 36 · 36/38-34-41-38
Safety Statements: 26 · 26-45-36/37/39-25-39
RIDADR: 2735 · UN2735
WGK Germany: 3 · 3
F: 1 · 1-10
Autoignition Temperature: 295 °C · 295 °C
TSCA: TSCA listed
HazardClass: 8 · 8
HS Code: 29310095 · 29310095
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Irrit. 2
REACH Registrations: Active
Limited Quantities: 1 L · 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 2.1% (22 of 1053) of reports.

Danger

H314 (48.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P332+P317, P337+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1053 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 4 items

Chemical: 1-Propanamine, 3-(trimethoxysilyl)-

1-Propanamine, 3-(trimethoxysilyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propanamine, 3-(trimethoxysilyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 05-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14372

3-(Trimethoxysilyl)-propylamine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

Hazards Summary · 1 item

Reacts with water and moisture producing methanol; Vapor causes severe eye irritation; Liquid causes severe conjunctivitis and corneal damage; May cause skin irritation and contact dermatitis; A respiratory tract irritant; Oral toxicity associated with the hydrolysis product methanol; [Gelest MSDS] See Methyl alcohol. See 3-Chloropropyltrimethoxysilane.

Hazard Classes and CategoriesSkin Corr. 1 (48.7%)

Safety & protection

Protective Action Criteria (PAC) · 3 items

9.0 [mg/m3]

99 [mg/m3]

600 [mg/m3]

Safety data

F: 1-10
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 3
tsca: TSCA listed
ridadr: UN2735
hs_code: 29310095
risk_code: 36/38-34-41-38
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: Xi,C
safety_code: 26-45-36/37/39-25-39
hazard_class: 8
Storage Class: 10 - Combustible liquids
Hazard statements: H315-H318
Limited Quantities: 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Skin Irrit. 2
Autoignition Temperature: 295 °C
Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364

Chemistry & industry

Uses & manufacturing

UsesPermitted for use as an inert ingredient in non-food pesticide products; [EPA]

U.S. Production2023: 1,000,000 - <5,000,000 lb

Consumer UsesBinder

Industry UsesAdhesion/cohesion promoter

Household ProductsInformation on 6 consumer products that contain 3-Aminopropyltrimethoxysilane in the following categories is provided:

General Manufacturing Information · 2 items

Rubber Product Manufacturing

1-Propanamine, 3-(trimethoxysilyl)-: ACTIVE

Applications · 3 items

Uses3-(Trimethoxysilyl)-1-propanamine is an amino-functional silane that may be used over a broad range of applications to give an improvement in the bond between a substrate, filler or reinforcement and resins that react with the amino group. 3-(Trimethoxysilyl)-1-propanamine is especially recommended to thermoplastic resins and thermosetting resins such as epoxy, PBT, polyurethane etc. It can improve reinforced plastic's physical properties and electric properties as flexural strength, compression strength and shear strength. It also can improve the dispersion and wet ability of filler in the high molecular materials. 3-(TRIMETHOXYSILYL)-1-PROPANAMINE is an excellent promoter of adhesion and sealant (such as polyurethane, epoxy, and phenol). In the glass wool and FRP products, it can be added into phenol resins to improve the wet resistance and mechanical performance. Applications: Superior adhesion promoter in RTV silicones and other hybrid sealants. Excellent adhesion promoter for difficult substrates such as ABC, PVC ad Poly Shyrene. Useful component in primer systems for hybrid and polyurethane sealants.

Uses(3-Aminopropyl)trimethoxysilane is used as a silane coupling agent on silver nanoparticles. It is also used in silanization processes. It is also used to prepare surface modified titanate nanotubes (TiNT).

General Description(3-Aminopropyl)trimethoxysilane(APTMS) is an amino-silane that is mainly used as a silane coupling agent for the surface modification of a variety of nanomaterials. APTMS based films form a thermally stable layer on different substrates.