CAS 119-28-8 Cleve's acid (HCID 8386)

Overview

determination of nitrite formation from nitrate by bacteria

Names & identifiers

Preferred name: Cleve's acid
IUPAC: 8-aminonaphthalene-2-sulfonic acid
English name: 1-Naphthylamine-7-sulfonic acid
Molecular formula: C10H9NO3S
Molecular weight: 223.25

Names & synonyms

8-AMINONAPHTHALENE-2-SULFONIC ACIDCleve's acidRefChem:73666119-28-88-Amino-2-naphthalenesulfonic acid1-Naphthylamine-7-sulfonic acid1,7-Cleve's acid2-Naphthalenesulfonic acid, 8-amino-1-Amino-7-sulfonaphthalene1-Amino-7-naphthalenesulfonic acid1-Aminonaphthalene-7-sulfonic acid8-Naphthylamine-2-sulfonic acid

Show more names

SODIUM NAPHTHIONATESODIUM NAPTHIONATE1.7 Clevs AcidCleve's O-acid1,7-CLEVES ACIDCLEVES ACID-1,7

Cleve's theta-acidC.I. 261351-amino-naphthalene-7-sulphonic acidMFCD00004032Cleve's .theta.-acidNSC 4983NSC-49831-aminonaphthalene-7-sulphonic acid

Database identifiers

CAS: 119-28-8
PubChem CID: 8386
DTXSID: DTXSID7059486
ChEMBL: CHEMBL4165941
UNII: 21QEG50798
EC Number: 204-311-4
Nikkaji: J5.312K

Properties

Computed structural properties

XLogP: 1.2
Topological polar surface area: 88.8 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 4
Rotatable bonds: 1
Heavy atoms: 15
Formal charge: 0
Complexity: 322

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Other Organic Compounds

Physical DescriptionSolid; [Merck Index]

Physicochemical properties

Melting point: 300 °C · ≥300 °C(lit.)
Boiling point: 220 °C · 220°C (rough estimate)
Density: 1.3588 · 1.3588 (rough estimate)
refractive index: 1.65 · 1.6500 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Aqueous Base (Slightly), DMSO (Slightly, Sonicated)
form: Powder
pka: 1 · pK1: 3.66 (25°C)
Appearance: Gray to brown Solid
Merck: 14 · 14,2351
BRN: 2115629 · 2115629
InChI: InChI=1S/C10H9NO3S/c11-10-3-1-2-7-4-5-8(6-9(7)10)15(12,13)14/h1-6H,11H2,(H,12,13,14)
InChIKey: QEZZCWMQXHXAFG-UHFFFAOYSA-N
SMILES: C1=C2C(C=CC=C2N)=CC=C1S(O)(=O)=O
CAS DataBase Reference: 119 · 119-28-8(CAS DataBase Reference)
FDA UNII: 21 QEG50798 · 21QEG50798
NIST Chemistry Reference: 1 · 1-Naphthylamine-7-sulfonic acid(119-28-8)
EPA Substance Registry System: 2 · 2-Naphthalenesulfonic acid, 8-amino- (119-28-8)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 260 · P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE: 3 · Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes: C
Risk Statements: 34 · 34
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 2585 · UN 2585 8/PG 3
WGK Germany: 2 · 2
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29214500 · 29214500
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 2 · Skin Irrit. 2
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 3.9% (2 of 51) of reports.

Danger

H314 (86.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 51 reports by companies from 6 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 3 items

Chemical: 2-Naphthalenesulfonic acid, 8-amino-

Status: Active Update: 22-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20714

2-Naphthalenesulfonic acid, 8-amino-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses burns; May cause allergic reactions in sensitive individuals; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Aldrich MSDS]

Hazard Classes and CategoriesSkin Corr. 1B (86.3%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.

Safety data

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
wgk: 2
tsca: TSCA listed
ridadr: UN 2585 8/PG 3
hs_code: 29214500
risk_code: 34
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: III
Hazard statements: H314
REACH Registrations: Active
Hazard Classifications: Skin Irrit. 2
Precautionary statements: P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

Chemistry & industry

Uses & manufacturing

UsesUsed to make azo dyes; [Merck Index] Used as an indicator of nitrite formation from nitrate by bacteria; [ChemIDplus]

General Manufacturing Information2-Naphthalenesulfonic acid, 8-amino-: ACTIVE

Applications · 2 items

UsesIntermediate of dyestuff

Uses8-Amino-2-naphthalenesulfonic acid can be used as a reactant to synthesize: Fe3O4/sulfonated polyaniline composite material via chemical oxidative polymerization with aniline in the presence of magnetite (Fe3O4) nanoparticles. Prismatic crystals of strychnine-8-ammonio-2-naphthalenesulfonate-water by heating with strychnine in water/ethanol solvent mixture.5-amino-9-dialkylamino benzo[a]phenoxazine dyes (Nile blue analogs) by condensation with N-alkyl or N-sulfo-propyl 4-arylazo-substituted 3-hydroxyaniline.

Upstream & downstream products

Upstream raw materials

Downstream products

Sulphur Blue CV Peri acid disodium 3-[[4-[[4-amino-6(or 7)-sulphonatonaphthyl]azo]phenyl]azo]-6-[(2,4-diaminophenyl)azo]-4-hydroxynaphthalene-2-sulphonate 1-Aminonaphthalene-6-sulfonic acid Direct Blue 71 1-Amino-7-naphthol ACID ORANGE 51 C.I. Mordant Brown 90 1,4-Benzenedisulfonic acid, 2-[[4-[[4-[(2,4-diamino-5-nitrophenyl)azo]-6-sulfo-1-naphthalenyl]azo]-1-naphthalenyl]azo]-, trisodium salt tetrasodium 2-[[2-amino-6-[[4-[[4-[(3-carboxylato-4-hydroxyphenyl)azo]-7-sulphonato-1-naphthyl]azo]-2,5-dimethoxyphenyl]azo]-5-hydroxy-7-sulphonato-1-naphthyl]azo]-5-nitrobenzoate Direct Black 197 Direct Black 24

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

宁波君龙新材料有限公司0574 88552216 19032109277 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

Related reactions

9 records

New reaction record

HRID 255629As reactantuspto-grants-1987_10

HRID 372359As reactantuspto-grants-1978_05

HRID 372360As productuspto-grants-1978_05

HRID 528793As reactantuspto-grants-2016_05

HRID 528800As reactantuspto-grants-2016_05

HRID 528801As reactantuspto-grants-2016_05

HRID 719181As reactantuspto-grants-2006_11

HRID 1904174As productuspto-grants-1989_06

Compound notes

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Basic information