CAS 14518-69-5 Phosphonium, tetrabutyl-, hydroxide (1:1) (HCID 84487)

Names & identifiers

Preferred name: Phosphonium, tetrabutyl-, hydroxide (1:1)
IUPAC: tetrabutylphosphanium hydroxide
English name: Tetrabutylphosphonium hydroxide
Molecular formula: C16H37OP
Molecular weight: 276.44

Names & synonyms

Tetrabutylphosphonium hydroxidePhosphonium, tetrabutyl-, hydroxide (1:1)EINECS 238-528-0DTXSID70884758RefChem:173623DTXCID001024182UN3267Phosphonium, tetrabutyl, hydroxide (1:1)238-528-014518-69-5tetrabutylphosphanium;hydroxideMFCD00068456

Show more names

TBPHTETRA-N-BUTYLPHOSPHONIUM HYDROXIDETBPH (40% in Water)40%w/waqueoussolutionphosphonium hydroxidetetrabutylphosphaniumTetrabutylphosphine hydroxideTTETRABUTYLPHOSPHONIUMHYDROXIDE

Tetrabutylphosphonium Hydroxide (40% in Water)tetrabutylphosphanium hydroxidePhosphonium, tetrabutyl-, hydroxide (1:1); Phosphonium, tetrabutyl-, hydroxide (8CI,9CI); Tetrabutylphosphonium hydroxide (6CI,7CI); Tetra-n-butylphosphonium hydroxidePhosphonium,tetrabutyl-, hydroxide (1:1)tetrabutylphosphonium;hydroxideSCHEMBL108027C16H37OPAKOS015950702

Database identifiers

CAS: 14518-69-5
PubChem CID: 84487
DTXSID: DTXSID70884758
EC Number: 238-528-0

Properties

Computed structural properties

Topological polar surface area: 1 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 1
Rotatable bonds: 12
Heavy atoms: 18
Formal charge: 0
Complexity: 116

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Phosphorus Compounds

Physical Description · 2 items

Liquid

40% Aqueous solution: Clear liquid; [Alfa Aesar MSDS]

Physicochemical properties

Density: 0.989 g/mL · 0.989 g/mL at 25 °C
refractive index: 20 · n20/D 1.412
form: Liquid
Specific Gravity: 0.989 · 0.989
color: Clear colorless to slightly yellow
Water Solubility: Miscible with water.
Hydrolytic Sensitivity: 0 · 0: forms stable aqueous solutions
BRN: 4826225 · 4826225
InChI: InChI=1S/C16H36P.H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H2/q+1;/p-1
InChIKey: DFQPZDGUFQJANM-UHFFFAOYSA-M
SMILES: [P+](CCCC)(CCCC)(CCCC)CCCC.[OH-]
CAS DataBase Reference: 14518 · 14518-69-5(CAS DataBase Reference)
EPA Substance Registry System: Phosphonium, tetrabutyl-, hydroxide (1:1) (14518-69-5)
UNSPSC Code: 12352000 · 12352000
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 501 · P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C
Risk Statements: 34 · 34
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 3267 · UN 3267 8/PG 2
WGK Germany: -
F: 10 · 10-34
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: II
HS Code: 29319019 · 29319019
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 B · Skin Corr. 1B
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H290 (11.1%): May be corrosive to metals [Warning Corrosive to Metals]

P234, P260, P264, P270, P273, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P390, P391, P405, P406, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 54 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Phosphonium, tetrabutyl-, hydroxide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphonium, tetrabutyl-, hydroxide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 04-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18768

Hazards Summary40% Aqueous solution: Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS]

Hazard Classes and CategoriesMet. Corr. 1 (11.1%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.

Safety data

F: 10-34
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: -
tsca: TSCA listed
ridadr: UN 3267 8/PG 2
hs_code: 29319019
risk_code: 34
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: II
Hazard statements: H314
REACH Registrations: Active
Hazard Classifications: Skin Corr. 1B
Precautionary statements: P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405

Chemistry & industry

Uses & manufacturing

U.S. Production2023: 75,000 - <500,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 items

Not Known or Reasonably Ascertainable

Phosphonium, tetrabutyl-, hydroxide (1:1): ACTIVE

Applications · 2 items

UsesTetrabutylphosphonium Hydroxide is a phase transfer catalyst for the etherification of thiosalicylic acid and analogs. Tetrabutylphosphonium Hydroxide is a pretreatment for rice husks that enhances enzymic and acid hydrolysis yields. Tetrabutylphosphonium Hydroxide is used in the synthesis of tetrabutylphosphonium carboxylate as a recyclable and highly selective catalysts for alcoholysis reaction of propylene oxide.

UsesTetrabutylphosphonium Hydroxide (TBPH) is a quaternary phosphonium salt. It is an effective catalyst in a variety of reactions. It is a strong base that can be used as a strong organic base catalyst. Its basicity combined with its function as phase transfer catalyst makes it a versatile catalyst in many biphasic organic transitions used in the manufacture of polymers, pharmaceuticals, agrochemicals, flavors and fragrances. Also it finds use as (trans)esterification catalyst for the preparation of several monomers,polymers and a cleaning agent for printed circuit boards and semiconductor wafers. Applications: Glycidyl Ether Intermediates used in pharmaceutical applications. Chemicals for Polymer Applications.