Basic information
- CAS
120-93-4- Standard SMILES
O=C1NCCN1- InChIKey
YAMHXTCMCPHKLN-UHFFFAOYSA-N- Molecular formula
- C3H6N2O
- Average molar mass
- 86.09 g/mol
- Monoisotopic mass
- 86.04801282
Names & identifiers
- Preferred name
- 2-Imidazolidinone
- IUPAC
- imidazolidin-2-one
- English name
- 2-Imidazolidone
- Molecular formula
- C3H6N2O
- Molecular weight
- 86.09
Names & synonyms
2-Imidazolidoneimidazolidin-2-one120-93-42-ImidazolidinoneETHYLENEUREAimidazolidinoneEthylene urea2-Oxoimidazolidine1,3-EthyleneureaMonoethyleneurea2-OxomidazolidineSD 6073
Show more names
ImidazolidoneidoneEthylene urea anhydrousEthylenurea1,3-ethylene-uresd6073
Urea, N,N'-(1,2-ethanediyl)-DTXSID0020602NSC-21314DTXCID206022K48456N55CHEBI:37001RefChem:596753CHEBI:55370
Database identifiers
- CAS
120-93-4- PubChem CID
- 8453
- DTXSID
DTXSID0020602- ChEMBL
CHEMBL12034- ChEBI
CHEBI:37001- UNII
- 2K48456N55
- EC Number
- 204-436-4
- Nikkaji
- J9.352A
Properties
Computed structural properties
- XLogP
- -1.3
- Topological polar surface area
- 41.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 63
Experimental & physicochemical properties
Color/Form
NEEDLES FROM CHLOROFORM
WHITE LUMPY POWDER
Solubility
VERY SOL IN WATER & IN HOT ALC; DIFFICULTLY SOL IN ETHER
SLIGHTLY SOL IN CHLOROFORM
Melting Point131 °C
Physical Description
CBI; Liquid
White odorless solid; [Hawley] Light yellow crystals; [Aldrich MSDS]
Physicochemical properties
- Melting point
- 129 · 129-132 °C (lit.)
- Boiling point
- 158.75 °C · 158.75°C (rough estimate)
- Density
- 1.153 · 1.1530 (rough estimate)
- vapor pressure
- 0.002 Pa · 0.002Pa at 20℃
- refractive index
- 1.511 · 1.5110 (estimate)
- Flash point
- 265 °C · 265°C
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder or Crystalline Powder
- pka
- 14.58 · 14.58±0.20(Predicted)
- color
- White to off-white
- Odor
- odorless
- Water Solubility
- soluble
- Merck
- 14 · 14,4914
- BRN
- 106252 · 106252
- Cosmetics Ingredients Functions
- PERFUMINGFRAGRANCE
- InChI
- 1S/C3H6N2O/c6-3-4-1-2-5-3/h1-2H2,(H2,4,5,6)
- InChIKey
- YAMHXTCMCPHKLN-UHFFFAOYSA-N
- SMILES
- O=C1NCCN1
- LogP
- -1.16 at · -1.16 at 25℃
- CAS DataBase Reference
- 120 · 120-93-4(CAS DataBase Reference)
- Indirect Additives used in Food Contact Substances
- 2 · 2-IMIDAZOLIDINONE
- FDA 21 CFR
- 175.105 · 175.105
- FDA UNII
- 2 K48456N55 · 2K48456N55
- NIST Chemistry Reference
- 2 · 2-Imidazolidinone(120-93-4)
- EPA Substance Registry System
- 2 · 2-Imidazolidinone (120-93-4)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 7 · GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- 319 · H319-H373
- Precautionary statements
- 260 · P260-P264-P280-P305+P351+P338-P314-P337+P313
- target organs
- Thyroid
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26
- WGK Germany
- 1 · 1
- RTECS
- 570000 · NJ0570000
- TSCA
- TSCA listed
- HS Code
- 29339900 · 29339900
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 2 STOT · Eye Irrit. 2STOT RE 2
- Hazardous Substances Data
- 120 · 120-93-4(Hazardous Substances Data)
- Toxicity
- 50 · mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 235, 1982.
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.1% (1 of 857) of reports.
Warning
H319 (99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H361 (13%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]；H373 (24.3%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P203, P260, P264+P265, P280, P305+P351+P338, P318, P319, P337+P317, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 857 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 857 reports by companies.；There are 13 notifications provided by 856 of 857 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: 2-Imidazolidinone
Commission Regulation No 844/2012
2-Imidazolidinone is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Imidazolidinone are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 15-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12504
Ethylene urea: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryAn irritant; [Aldrich MSDS] Intraperitoneal LD50 (mouse) = 500 mg/kg; [RTECS]
Hazard Classes and CategoriesEye Irrit. 2 (99.9%)；Repr. 2 (13%)；STOT RE 2 (24.3%)
Toxicology
Plant Concentrations
MANCOZEB, 2-IMIDAZOLINE & ETHYLENEUREA RESIDUES WERE DETERMINED IN TOMATO & POTATO CROPS AFTER FIELD TREATMENT WITH MANCOZEB. LOW LEVELS (LESS THAN 0.04 PPM) OF ETHYLENEUREA WERE PRESENT IN TOMATOES UP TO 28 DAYS AFTER SPRAYING. ETHYLENEUREA WAS NOT DETECTABLE IN POTATO TUBERS.
Non-Human Toxicity Excerpts
ETHYLENEUREA INDUCED CANCER IN RATS & MICE WHEN ADDED TO FOOD WITH SODIUM NITRITE.
EFFECTS OF 0.125-2.0 MG/ML ETHYLENEUREA IN VITRO ON XENOPUS LAEVIS SPERMATOZOA PRODUCED HIGH YIELDS OF ABNORMAL EMBRYO.
IN SALMONELLA TYPHIMURIUM HIS G-46, ETHYLENEUREA SHOWED RELATIVE MUTAGENIC ACTIVITY OF 0.9, WITH ACTIVITY DUE TO SPONTANEOUS REVERSIONS BEING 1.0.
SINGLE DOSE (480 MG/KG INTRAGASTRICALLY) OF ETHYLENEUREA WAS ADMINISTERED TO FEMALE WISTAR RATS ON DAY 12 OR 13 OF GESTATION. IT WAS NEITHER MATERNALLY TOXIC NOR TERATOGENIC (ALTHOUGH MINOR SKELETAL CHANGES WERE PRESENT).
Regulatory information
Regulatory Information
Chemical: 2-Imidazolidinone
Commission Regulation No 844/2012
2-Imidazolidinone is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Imidazolidinone are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 15-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12504
Ethylene urea: Does not have an individual approval but may be used under an appropriate group standard
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- NJ0570000
- hs_code
- 29339900
- Toxicity
- mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 235, 1982.
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS08
- hazard_code
- Xi
- safety_code
- 26
- Storage Class
- 11 - Combustible Solids
- target organs
- Thyroid
- Hazard statements
- H319-H373
- REACH Registrations
- Active
- Hazard Classifications
- Eye Irrit. 2STOT RE 2
- Precautionary statements
- P260-P264-P280-P305+P351+P338-P314-P337+P313
- Hazardous Substances Data
- 120-93-4(Hazardous Substances Data)
Chemistry & industry
Pharmacology
Metabolism/Metabolites
METABOLISM STUDY IN RATS INDICATES THAT DEHYDROGENATION OF (14)C-ETHYLENEUREA IS EXTENSIVE YIELDING IMIDAZOLE AS MAJOR URINARY METABOLITE. COMPOUND WAS ADMINISTRATED ORALLY.
IN MICE TREATED ORALLY WITH (14)C-LABELED ETHYLENETHIOUREA, ETHYLENEBISDIISOTHIOCYANATO SULFIDE, MANEB, & ZINEB, ETHYLENEUREA WAS A URINARY METABOLITE.
Uses & manufacturing
Uses
Used to make high polymers, plasticizers, lacquers, adhesives, and textile and leather finishing agents; Also used as an insecticide; [HSDB]
Farming (Pesticides) [Category: Industry]
MFR HIGH POLYMERS; IN FORMULATION OF PLASTICIZERS, LACQUERS, & ADHESIVES; INSECTICIDE
CHEM INT FOR TEXTILE & LEATHER FINISHING AGENTS
U.S. Exports
(1975) No Data
(1977) No Data
U.S. Imports
(1975) No Data
(1977) No Data
U.S. Production
2023: 250,000 - <400,000 lb；2022: 250,000 - <400,000 lb；2021: 250,000 - <400,000 lb；2020: 400,000 - <550,000 lb
(1975) No Data
(1977) No Data
Consumer UsesFragrance；Solvent
Industry UsesIntermediate；Fragrance；Wrinkle resisting agent
Methods of Manufacturing
REACTION OF ETHYLENEDIAMINE AND UREA
PREPD FROM ETHYLENEDIAMINE & CARBON DIOXIDE UNDER INFLUENCE OF HEAT & PRESSURE...
Household ProductsInformation on 1 consumer products that contain Imidazolidinone in the following categories is provided:；• Inside the Home
Use Classification
Fragrance Ingredients
Environmental transformation -> Pesticide transformation products (metabolite, successor)
General Manufacturing Information
All Other Chemical Product and Preparation Manufacturing；All Other Basic Organic Chemical Manufacturing；Textiles, apparel, and leather manufacturing
2-Imidazolidinone: ACTIVE
Applications
Description2-imidazolidone is a largely obsolete insecticide. Very little information has been published regarding its environmental fate. Toxicity to earthworms is moderate but for most other species toxicity appears to be low. 2-imidazolidone has a low oral mammalian toxicity.
Uses2-Imidazolidinone is a metabolite of ethylenethiourea (ETU), a decomposition product of the ethylenebis(dithiocarbamate) (EBDC) fungicides.
Usesthiadiazole pharmaceutical intermediate
Uses2-Imidazolidone can be used as reactant for synthesis of Chiral microporous materials from achiral precursors.
General DescriptionFind more information here: Neonicotinoids
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
Syntechem Co.,Ltd[email protected]
南京药石科技股份有限公司025-86918202 4000255188 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
山东鑫恒诚化工有限公司18660169893 · [email protected]
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嘉兴市艾森化工有限公司0573-85285100 18627885956 · [email protected]
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孝感深远化工有限公司15527621225; 15527621225 · [email protected]
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玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
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天津希恩思生化科技有限公司400 638 7771 · [email protected]
Connect Chemicals GmbH+49 2102 2077 19 · [email protected]
河南多贝化工有限公司0370-2785118 17550508557 · [email protected]
北京泰亚杰科技有限公司021-33690831-8001 13552411790;18616022633 · [email protected]
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赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
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南京诺利斯医药科技有限公司13901585132 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
上海健超生物科技有限公司150-2103-5486 18017383231 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
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湖北楚烁生物科技有限公司19107272865
北京环宇世纪化学科技有限公司hysj_bj.com
上海将来实业股份有限公司021-61552785 · [email protected]
安徽科迪达化工有限公司0554-2106669 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
日照力德士化工有限公司010-51268198 · [email protected]
郑州鸿晟医药科技有限公司0371-0371-13526885213 15637198702 · [email protected]
美岚实业（上海）有限公司021-58958189 · [email protected]
上海石洋化工有限公司021-56795766 · [email protected]
上海爱蝶实业有限公司021-58957966 18930537195 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
广拓化学（上海）有限公司021-60899189-8001 18918189673 · [email protected]
上海御略医药科技有限公司021-60345187 13671753212 · [email protected]
Additional notes
DefinitionChEBI: Imidazolidin-2-one is a member of ureas and an imidazolidinone.
Related reactions
181 records
Compound notes
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