HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl acrylate
Einecs 240-741-9 · Hydroxy-PEG3-acrylate · Triethylene glycol monoacrylate · 2-[2-(2-hydroxyethoxy)ethoxy]ethyl acrylate · 2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHYL PROP-2-ENOATE · Acrylic acid 2-[2-(2-hydroxyethoxy)ethoxy]ethyl ester · 2-Propenoic acid,2-[2-(2-hydroxyethoxy)ethoxy]ethyl ester
Identifiers & Physical Properties
| CAS No. | 16695-45-7 |
|---|---|
| Molecular formula | C9H16O5 |
| Average molar mass | 204.22 g/mol |
| Monoisotopic mass | 204.09977361 g/mol |
| SMILES | C=CC(=O)OCCOCCOCCO |
| InChIKey | VETIYACESIPJSO-UHFFFAOYSA-N |
| PubChem CID | 85549 |
| EC No. | 240-741-9 |
| DTXSID | DTXSID30168208 |
Chemical & Physical Properties
| XLogP | -0.3 |
|---|---|
| Topological polar surface area | 65 |
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 5 |
| Rotatable bonds | 10 |
| Heavy atoms | 14 |
| Formal charge | 0 |
| Complexity | 157 |
| Boiling point | 302.4±22.0 °C(Predicted) |
| Density | 1.098±0.06 g/cm3(Predicted) |
| Solubility | Soluble in DMSO, DCM, DMF |
| pKa (acidity coefficient) | 14.36±0.10(Predicted) |
| FDA UNII | O530A23BH3 |
Applications & Uses
Description
Hydroxy-PEG3-acrylate is a PEG linker containing a hydroxyl group and an acrylate group. The hydroxyl group allows for further derivatization of the compound. The acrylate group enables Michael addition reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].