Basic information
- Standard SMILES
COCCCOCCCOC- InChIKey
KWDCKLXGUZOEGM-UHFFFAOYSA-N- Molecular formula
- C8H18O3
- Average molar mass
- 162.23 g/mol
- Monoisotopic mass
- 162.12559444
Names & identifiers
- Preferred name
- 1-Methoxy-3-(3-methoxypropoxy)propane
- IUPAC
- 1-methoxy-3-(3-methoxypropoxy)propane
- English name
- Dipropylene Glycol Dimethyl Ether
- Molecular formula
- C8H18O3
- Molecular weight
- 162.23
Names & synonyms
1-methoxy-3-(3-methoxypropoxy)propane66226-74-2DTXSID90274213RefChem:197053DTXCID8022327601-045-4111109-77-4Propane, 1,1'-oxybis[3-methoxy-Propane, oxybis(methoxy-MFCD32691319Propane, oxybis[methoxy-Proglyde(R) DMM
Show more names
DIPROPYLENE GLYCOL DIMETHYL ETHERDPDMEDPGDMEBIS(METHOXYPROPYL) ETHERDimethoxy dipropyleneglycolPROGLYDE(TM) DMMProglyde? DMMDMM/DMEUNII:5C48QQD0H3
methoxy-propyl-etherDSSTox_CID_22327DSSTox_RID_79997UNII-Q4KC92LJ05DSSTox_GSID_42327SCHEMBL117963Q4KC92LJ05CHEMBL3182517
Database identifiers
- CAS
111109-77-4、66226-74-2- PubChem CID
- 86302
- DTXSID
DTXSID90274213- ChEMBL
CHEMBL3182517- EC Number
- 404-640-5、601-045-4
- Nikkaji
- J1.781.508C
Properties
Computed structural properties
- XLogP
- 0.5
- Topological polar surface area
- 27.7 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 8
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 58.4
Experimental & physicochemical properties
SolventsSolvents -> Glycol Ethers (Glymes)
FragrancesFragrance Ingredient (Propane, oxybis[methoxy-) -> IFRA transparency List
Physical Description
Liquid; Other Solid; Liquid; CBI
Clear colorless liquid; [Sigma-Aldrich MSDS] Mild odor; [Dow Chemical MSDS]
Physicochemical properties
- Melting point
- -80 °C · -80°C
- Boiling point
- 175 °C · 175 °C(lit.)
- Density
- 0.903 g/mL · 0.903 g/mL at 20 °C(lit.)
- vapor pressure
- 0.8 hPa · 0.8 hPa (20 °C)
- refractive index
- 20 · n20/D 1.408
- Flash point
- 149 °F · 149 °F
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- 526 g/l · 526g/l
- form
- clear liquid
- color
- Colorless to Almost colorless
- Specific Gravity
- 0.907 · 0.907
- explosive limit
- 0.77 · 0.77-5.57%(V)
- Cosmetics Ingredients Functions
- SOLVENT
- InChI
- 1S/C8H18O3/c1-9-5-3-7-11-8-4-6-10-2/h3-8H2,1-2H3
- InChIKey
- FWZJTQPVXZIABW-UHFFFAOYSA-N
- SMILES
- COCC(C)OC(C)COC
- LogP
- 0.434 · 0.434 (est)
- CAS DataBase Reference
- 111109 · 111109-77-4(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 4 KC92LJ05 · Q4KC92LJ05
- EPA Substance Registry System
- Propane, oxybis[methoxy- (111109-77-4)
- UNSPSC Code
- 12352112 · 12352112
- NACRES
- 23 · NA.23
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 227 · H227
- Precautionary statements
- 210 · P210-P280-P403+P235-P501
- PPE
- Eyeshields, Gloves, type ABEK (EN14387) respirator filter
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 23 · 23-24/25-26-36
- RIDADR
- 1993 · NA 1993 / PGIII
- WGK Germany
- 1 · 1
- RTECS
- 5487500 · TZ5487500
- Autoignition Temperature
- 165 °C · 165 °C DIN 51794
- TSCA
- TSCA listed
- HS Code
- 29091990 · 29091990
- Storage Class
- 10 · 10 - Combustible liquids
- Toxicity
- 50 orally · LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rat > 2000 mg/kg
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 35.6% (339 of 953) of reports.
Warning
H319 (64.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Aggregated GHS information provided per 953 reports by companies from 5 notifications to the ECHA C&L Inventory.
This chemical does not meet GHS hazard criteria for 100% (272 of 272) of all reports.
Hazard information
Regulatory Information
Chemical: Propane, oxybis[methoxy-
Propane, oxybis[methoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propane, oxybis[methoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/15643
Dipropylene glycol dimethyl ether: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
A skin and strong eye irritant; [Sigma-Aldrich MSDS] May cause moderate eye irritation; Demonstrates limited potential to cause skin sensitization; Animal studies have shown effects on the adrenal gland, kidney, and liver, fetal toxicity at doses maternally toxic, and no evidence of teratogenicity, reproductive toxicity, or mutagenicity; [Dow Chemical MSDS] See Monoglyme.
Hazard Classes and Categories
Eye Irrit. 2 (64.4%)
Not Classified
Toxicology
Adverse EffectsNeurotoxin - Acute solvent syndrome
Toxicity DataLC50 (rat) > 792 ppm/4hr
Safety data
- PPE
- Eyeshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- TZ5487500
- ridadr
- NA 1993 / PGIII
- hs_code
- 29091990
- Toxicity
- LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rat > 2000 mg/kg
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 23-24/25-26-36
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H227
- REACH Registrations
- Active
- Autoignition Temperature
- 165 °C DIN 51794
- Precautionary statements
- P210-P280-P403+P235-P501
Chemistry & industry
Uses & manufacturing
U.S. Production2023: 700,000 - <850,000 lb
Consumer UsesSolvent
Industry UsesSolvent
Use ClassificationFragrance Ingredients
General Manufacturing Information
All Other Chemical Product and Preparation Manufacturing
Propane, oxybis[methoxy-: ACTIVE
Applications
DescriptionDipropylene Glycol Dimethyl Ether is unique among propylene oxide-based solvents in that it is aprotic (no hydroxyl functionality). As a result, it is relatively inert and can be used in protonsensitive systems such as water-based polyurethane coatings. Dipropylene Glycol Dimethyl Ether can also be used as an azeotroping solvent for esterification reactions. And with its excellent stability, solvency, and coupling performance, Dipropylene Glycol Dimethyl Ether provides excellent compatibility with a wide range of agricultural formulations and cleaning products.
Uses1-Methoxy-2-((1-methoxypropan-2-yl)oxy)propane is used in method for evaluating profile of ink compound and manufacturing organic light emitting device comprising same.
UsesDipropylene glycol diMethyl ether can be used as aprotic solvent for use on proton-sensitive systems such as water-based polyurethane coatings.
Preparation methods
PreparationUsing dipropylene glycol and iodomethane as raw materials, a methylation reaction occurs under the action of an alkaline catalyst to produce dipropylene glycol dimethyl ether. The dipropylene glycol dimethyl ether system produced in the previous methylation reaction is subjected to solvent azeotropic dehydration, followed by cooling to precipitate salt. The salt is removed by filtration to obtain the filtrate. The third step is product purification: the filtrate obtained in the second step of azeotropic dehydration is separated by distillation, the solvent is recovered under normal pressure, and then purified target product dipropylene glycol dimethyl ether is obtained by vacuum distillation.
Suppliers11 total
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
上海毕得医药科技股份有限公司400-164-7117 18317119277 · [email protected]
武汉德拜技术有限公司18086626237 18086626237 · [email protected]
上海超岚化工科技中心（原宁波市超明生物科技有限公司）13301662590 · [email protected]
ATK CHEMICAL COMPANY LIMITED+undefined-21-51877795 · [email protected]
沈阳莫德医药科技有限公司024-23982345 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
上海捷世凯生物科技有限公司021-57520305 13795461237 · [email protected]
江苏艾康生物医药研发有限公司025-58859352 18651614124 · [email protected]
山东彬睿特新材料有限公司0533-2866658 15615638350 · [email protected]
河南威梯希化工科技有限公司0371-55135753 18003832934 · [email protected]
Related reactions
2 records
Linked notes
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