Basic information
- CAS
134-09-8- Standard SMILES
CC1CCC(C(C)C)C(OC(=O)c2ccccc2N)C1- InChIKey
SOXAGEOHPCXXIO-UHFFFAOYSA-N- Molecular formula
- C17H25NO2
- Average molar mass
- 275.4 g/mol
- Monoisotopic mass
- 275.18852904
Overview
Meradimate is a monoterpenoid.
Names & identifiers
- Preferred name
- Menthyl Anthranilate
- IUPAC
- (5-methyl-2-propan-2-ylcyclohexyl) 2-aminobenzoate
- English name
- Menthyl anthranilate
- Molecular formula
- C17H25NO2
- Molecular weight
- 275.39
Names & synonyms
MENTHYL ANTHRANILATE134-09-8MeradimateAnthranilic acid, p-menth-3-yl esterMeradimatoDTXSID3047895Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoateJ9QGD60OUZDTXCID3027871meradimatumRefChem:925487205-129-8
Show more names
MERADIMATE,USPMenthyl o-aminobenzoateMENTHYL ANTHRANILATE, USP STANDARDMenthyl Anthranilate (500 mg/ampule) (Meradimate)Meradimate (500 mg/ampule) (Menthyl Anthranilate)5-methyl-2-(1-methylethyl)-cyclohexano2-aminobenzoateHigh purity CAS 134-09-8 Menthyl anthranilate in stock
Meradimate [INN]Menthyl-O-aminobenzoate(5-methyl-2-propan-2-ylcyclohexyl) 2-aminobenzoate5-methyl-2-(propan-2-yl)cyclohexyl 2-aminobenzoate2-isopropyl-5-methylcyclohexyl 2-aminobenzoateNCGC00159361-02Cyclohexanol,5-methyl-2-(1-methylethyl)-, 1-(2-aminobenzoate)CAS-134-09-8
Database identifiers
- CAS
134-09-8
Properties
Computed structural properties
- XLogP
- 5.1
- Topological polar surface area
- 52.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 4
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 329
Experimental & physicochemical properties
CosmeticsUv absorber
SolubilityInsoluble
Boiling Point177-179 ºC
Physicochemical properties
- Melting point
- 62.5 · 62.5-63.5°
- Boiling point
- 177 · 177-179 °C3 mm Hg(lit.)
- Density
- 1.04 g/mL · 1.04 g/mL at 25 °C(lit.)
- refractive index
- 20 · n20/D 1.542(lit.)
- Flash point
- 230 °F · >230 °F
- storage temp.
- 2 · 2-8°C
- pka
- 2.17 · 2.17±0.10(Predicted)
- form
- liquid
- Odor
- 100 % · at 100.00 %. grape menthol
- Odor Type
- fruity
- Cosmetics Ingredients Functions
- UV ABSORBER
Safety & regulation
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 64 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoate
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoate: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- PPE
- Eyeshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 2922493800
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36
- Storage Class
- 10 - Combustible liquids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
Chemistry & industry
Pharmacology
Protein BindingAs meradimate is not absorbed, this pharmacokinetic property is not relevant.
PharmacodynamicsMeradimate effect provides a low-level, broad-spectrum protecting coverage effect.
Mechanism of Action
Meradimate acts by absorbing both the UVA and UVB radiation, this provides this ingredient with a broad spectrum and it explains why it is highly used in different products such as lip balms, lipsticks, and moisturizers. Its protective effective action does not cover completely the UVA rays as it only reaches 336 nm. This has been proven even thought meradimate has a theoretical protective coverage range between 200-380 nm. Its function is related to the intrinsic structure of meradimate which is an ortho-disubstituted aminobenzoate. This structure allows easy electron delocalization and shifts in the maximum absorption.
Biological Half-LifeAs meradimate is not absorbed, this pharmacokinetic property is not relevant.
Metabolism/MetabolitesAs meradimate is not absorbed, this pharmacokinetic property is not relevant.
Absorption, Distribution and Excretion
Meradimate is not absorbed through the skin.
As meradimate is not absorbed, this pharmacokinetic property is not relevant.
As meradimate is not absorbed, this pharmacokinetic property is not relevant.
As meradimate is not absorbed, this pharmacokinetic property is not relevant.
Uses & manufacturing
Household ProductsInformation on 1 consumer products that contain Menthyl anthranilate in the following categories is provided:
Use ClassificationCosmetics -> Uv absorber
Related reactions
2 records
Compound notes
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