HuagongsheHuagongshe Chemistry Print Report · For research reference only

HCID 86636902Generated: October 30, 2026

5-(Trifluoromethyl)thiophene-2-sulfonyl chloride

uoromethyl)thiophene-2-sulfonyl chloride · 5-(Trifluoromethyl)thien-2-sulfonyl chloride · 5-(Trifluoromethyl)thiophene-2-sulfonyl chloride · 2-Thiophenesulfonyl chloride, 5-(trifluoromethyl)- · 5-(trifluoromethyl)Thien-2-sulfonyl chloride5-(trifluoromethyl)thiophene-2-sulfonyl chloride

https://huagongshe.com/en/chemical/86636902

5-(Trifluoromethyl)thiophene-2-sulfonyl chloride molecular structure

Identifiers & Physical Properties

CAS No.	954377-22-1
Molecular formula	C5H2ClF3O2S2
Average molar mass	250.6 g/mol
Monoisotopic mass	249.9136838 g/mol
SMILES	O=S(=O)(Cl)c1ccc(C(F)(F)F)s1
InChIKey	PWVUZSSHOGAMPC-UHFFFAOYSA-N
PubChem CID	86636902
EC No.	825-181-0

Chemical & Physical Properties

XLogP	2.9
Topological polar surface area	70.8
Hydrogen bond donors	0
Hydrogen bond acceptors	6
Rotatable bonds	1
Heavy atoms	13
Formal charge	0
Complexity	281
Boiling point	269.7±40.0 °C(Predicted)
Density	1.681±0.06 g/cm3(Predicted)
Solubility	Acetonitrile (Sparingly), Chloroform (Sparingly)
Physical state	Oil
Color	Colourless
Stability	Hygroscopic, Moisture Sensitive
GHS pictogram	GHS05,GHS07
Signal word	Danger
GHS hazard statements	H314-H302
GHS precautionary statements	P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501

Safety & Regulations

GHS classification	DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard Classes and Categories	Acute Tox. 4 (100%)Skin Corr. 1B (100%)
Signal word	Danger
GHS pictogram	GHS05,GHS07
GHS hazard statements	H314-H302
GHS precautionary statements	P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501

5-(Trifluoromethyl)thiophene-2-sulfonyl chloride

CAS No.

954377-22-1

Molecular formula

C5H2ClF3O2S2

Average molar mass

250.6 g/mol

Monoisotopic mass

249.9136838 g/mol

SMILES

O=S(=O)(Cl)c1ccc(C(F)(F)F)s1

InChIKey

PWVUZSSHOGAMPC-UHFFFAOYSA-N

PubChem CID

86636902

EC No.

825-181-0

Chemical & Physical Properties

XLogP

2.9

Topological polar surface area

70.8

Hydrogen bond donors

Hydrogen bond acceptors

Rotatable bonds

Heavy atoms

Formal charge

Complexity

281

Boiling point

269.7±40.0 °C(Predicted)

Density

1.681±0.06 g/cm3(Predicted)

Solubility

Acetonitrile (Sparingly), Chloroform (Sparingly)

Physical state

Oil

Color

Colourless

Stability

Hygroscopic, Moisture Sensitive

GHS pictogram

GHS05,GHS07

Signal word

Danger

GHS hazard statements

H314-H302

GHS precautionary statements

P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501

Safety & Regulations

GHS classification

DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard Classes and Categories

Acute Tox. 4 (100%)Skin Corr. 1B (100%)