Phenazopyridine hydrochloride
Basic information
- CAS
136-40-3- Standard SMILES
Cl.Nc1ccc(N=Nc2ccccc2)c(N)n1- InChIKey
QQBPIHBUCMDKFG-UHFFFAOYSA-N- Molecular formula
- C11H12ClN5
- Average molar mass
- 249.7 g/mol
- Monoisotopic mass
- 249.0781231
Overview
Phenazopyridine Hydrochloride can cause cancer according to an independent committee of scientific and health experts.
Names & identifiers
- Preferred name
- Phenazopyridine hydrochloride
- IUPAC
- 3-phenyldiazenylpyridine-2,6-diamine;hydrochloride
- English name
- Phenazopyridine hydrochloride
- Molecular formula
- C11H12ClN5
- Molecular weight
- 249.7
Names & synonyms
Phenazopyridine hydrochloride136-40-3Phenazopyridine HClPyridiumUrodineMallophenePyripyridiumAzomineBisterilDiridoneSeduralSuladyne
Show more names
nc150pyrizinuraziumuriplexdolonil
3-Phenylazo-2,6-diaminopyridine hydrochloridePhenazodinePyrazodineAzodynePiridPhenylazo tabletsDi-AzoPhenazopyridine.HCl
Database identifiers
- CAS
136-40-3- PubChem CID
- 8691
- DTXSID
DTXSID1021118- ChEMBL
CHEMBL1606101- ChEBI
CHEBI:71419- UNII
- 0EWG668W17
Properties
Computed structural properties
- Topological polar surface area
- 89.7 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 237
Experimental & physicochemical properties
Solubility30.4 [ug/mL] (The mean of the results at pH 7.4)
Collision Cross Section147.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 238 °C · 238 °C
- Boiling point
- 394.6 °C · 394.6°C (rough estimate)
- Density
- 1.2645 · 1.2645 (rough estimate)
- refractive index
- 1.611 · 1.6110 (estimate)
- Flash point
- Not applicable
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 5.2 · 5.20
- form
- powder to crystal
- color
- Orange to Brown to Dark purple
- Water Solubility
- 0.01 · 0.01-0.1 g/100 mL at 20 ºC
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Faceshields, Gloves
- wgk
- 3
- rtecs
- US7875000
- ridadr
- 2811
- hs_code
- 29333990
- Toxicity
- LD50 orally in rats: 403 mg/kg (Becker, Swift)
- risk_code
- 22-36/37/38-40-34-42/43
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS08
- hazard_code
- Xn,C
- safety_code
- 26-36/37-45-36/37/39-27-22
- Storage Class
- 10 - Combustible liquids
- target organs
- Respiratory system
- Hazard statements
- H302-H315-H319-H335-H351
- Hazard Classifications
- Acute Tox. 4 OralCarc. 2Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P202-P261-P301+P312-P302+P352-P305+P351+P338-P308+P313
Chemistry & industry
Applications
DescriptionPhenazopyridine is an azo dye with analgesic properties. It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg. Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
UsesPhenazopyridine hydrochloride has been used for 50 years as an analgesic drug either alone or in combination with other drugs to reduce pain associated with urinary tract infection. An azo dye used in urinary tract infections. Also used as a local anesthetic. Exposure to phenazopyridine hydrochloride occurs during manufacture and formulation.
UsesAn azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract).
Usesanticonvulsant, antieleptic
Usestherapeutic for urinary tract infections
General DescriptionBrick-red microcrystals with a slight violet luster or a purple powder. Aqueous solutions are yellow to brick-red and slightly acidic; they may be stabilized by the addition of 10% glucose. Slightly bitter taste.
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disord rs) and potential carcinogenicity.
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