Basic information
- CAS
136-69-6- Standard SMILES
CC(Cc1ccc2c(c1)OCO2)NCC(O)c1ccc(O)c(O)c1.Cl- InChIKey
LOVXREQUMZKFCM-UHFFFAOYSA-N- Molecular formula
- C18H22ClNO5
- Average molar mass
- 367.8 g/mol
- Monoisotopic mass
- 367.1186505
Overview
Protokylol Hydrochloride is the hydrochloride salt form of protokylol, a derivative of the beta-adrenergic receptor agonist isoproterenol with bronchodilator activity. Protokylol binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Names & identifiers
- Preferred name
- 1,2-Benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, hydrochloride (1:1)
- IUPAC
- 4-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochloride
- English name
- protokylol hydrochloride
- Molecular formula
- C18H21NO5.ClH
- Molecular weight
- 367.827
Names & synonyms
Protokylol hydrochloride136-69-6Protokylol HClNSC-1134907U7O8Q48IO1,2-Benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, hydrochloride (1:1)RefChem:57624205-254-8VentairePalisonCaytine hydrochlorideProtokylol (hydrochloride)
Show more names
NSC 113490LOVXREQUMZKFCM-UHFFFAOYSA-NProtokylol Hydrochloride (Mixture of DiastereoMers)α-[[(α-Methyl-3,4-Methylenedioxy- phenethyl)aMino]Methyl]protocatechuyl Alcohol Hydrochloride4-[2-[[2-(1,3-Benzodioxol-5-yl)-1-Methylethyl]aMino]-1-hydroxyethyl]-1,2-benzenediol Hydrochloride3,4-Dihydroxy-α-[[[α-Methyl-3,4-(Methylenedioxy)phenethyl] aMino]Methyl]benzyl Alcohol Hydrochloride
Caytine hydrochloride; NSC 1134904-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochlorideAsmetilBiturixBeresAtma-sanolProtokylol Hydrochloride(Mixture of Diastereomers)EINECS 205-254-8
Properties
Computed structural properties
- Topological polar surface area
- 91.2 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 6
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 396
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 126 · 126-127°
- FDA UNII
- 7 U7O8Q48IO · 7U7O8Q48IO
- Toxicity
- 50 orally · LD50 orally in rats: 938 ±96 mg/kg (Goldenthal)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 orally in rats: 938 ±96 mg/kg (Goldenthal)
Chemistry & industry
Applications
UsesProtokylol hydrochloride is a β-adrenergic agonist. Protokylol is used as a bronchodilator.
Suppliers10 total
凯试(上海)科技有限公司021-50135380 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
斯派螺（武汉）药物研发有限公司[email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
四川义研药物研究有限公司19949968070; 19949968070 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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