2-Chloro-6-methoxypyridine (HCID 87009)

Names & identifiers

Preferred name: 2-Chloro-6-methoxypyridine
IUPAC: 2-chloro-6-methoxypyridine
English name: 2-Chloro-6-methoxypyridine
Molecular formula: C6H6ClNO
Molecular weight: 143.57

Names & synonyms

2-Chloro-6-methoxypyridine17228-64-7Pyridine, 2-chloro-6-methoxy-6-Chloro-2-methoxypyridine2-Methoxy-6-chloropyridineEINECS 241-264-9DTXSID00169247PYRIDINE,2-CHLORO,6-METHOXYRefChem:86345DTXCID4091738241-264-9InChI=1/C6H6ClNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H

Show more names

Chloro-6-Methoxypyridoro-6-methoxypyridine2-Chlor-6-methoxypyridine2-Chloro-6-methoxypyridine 98%2-Chloro-6-methoxypyridine,98%

VAVGOGHLNAJECD-UHFFFAOYSA-N2-chloro-6-methoxy-pyridineMFCD000062656-methoxy-2-chloropyridineSCHEMBL336762SCHEMBL491297SCHEMBL932747orb3030305

Database identifiers

CAS: 17228-64-7
PubChem CID: 87009
DTXSID: DTXSID00169247
EC Number: 241-264-9
Nikkaji: J127.301I

Properties

Computed structural properties

XLogP: 3
Topological polar surface area: 22.1 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 9
Formal charge: 0
Complexity: 89.1

Physicochemical properties

Boiling point: 185 · 185-186 °C (lit.)
Density: 1.207 g/mL · 1.207 g/mL at 25 °C (lit.)
refractive index: 20 · n20/D 1.528(lit.)
Flash point: 169 °F · 169 °F
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
pka: 0.4 · 0.40±0.10(Predicted)
color: Colorless to Almost colorless
BRN: 1364500 · 1364500
InChI: InChI=1S/C6H6ClNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3
InChIKey: VAVGOGHLNAJECD-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(OC)=CC=C1
CAS DataBase Reference: 17228 · 17228-64-7(CAS DataBase Reference)
NIST Chemistry Reference: 2 · Pyridine, 2-chloro-6-methoxy-(17228-64-7)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36/37/39-37/39
RIDADR: 2810 · 2810
WGK Germany: 3 · 3
Hazard Note: Irritant
PackingGroup: III
HS Code: 29333990 · 29333990
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 3
ridadr: 2810
hs_code: 29333990
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
hazard_note: Irritant
safety_code: 26-36/37/39-37/39
Storage Class: 10 - Combustible liquids
packing_group: III
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Applications

Uses2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists.

General DescriptionThe FT-Raman and Fourier transform infrared (FTIR) spectra of 2-Chloro-6-methoxypyridine has been studied.