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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 8713Generated: October 23, 2026

2-Aminothiophenol

2-AMINOTHIOPHENOL · Aminothiophenol · 2-Amino · 2-MERCAPTOANILINE · O-AMINOTHIOPHENOL · a-Ethyl pyrrole · 2-AMINOBENZENTHIOL · O-AMINOBENZENETHIOL

https://huagongshe.com/en/chemical/8713

2-Aminothiophenol molecular structure

Identifiers & Physical Properties

CAS No.137-07-5
Molecular formulaC6H7NS
Average molar mass125.19 g/mol
Monoisotopic mass125.02992022 g/mol
SMILESNc1ccccc1S
InChIKeyVRVRGVPWCUEOGV-UHFFFAOYSA-N
PubChem CID8713
ChEMBLCHEMBL116835
ChEBICHEBI:91019
EC No.205-277-3
DTXSIDDTXSID6051693

Chemical & Physical Properties

XLogP1.4
Topological polar surface area27
Hydrogen bond donors2
Hydrogen bond acceptors2
Rotatable bonds0
Heavy atoms8
Formal charge0
Complexity74.9
Chemical classesOther Classes -> Sulfur Compounds
SpringerMaterials Properties13C nuclear magnetic resonance spectrum
Vapor pressure0.02 [mmHg]1 hPa (69 °C)
Physical DescriptionMelting point = 26 deg C[ChemIDplus] Liquid with a stenchSensitive to airmp = 19-21 deg C[Alfa Aesar MSDS]
Melting point23 °C
Boiling point70-72 °C0.2 mm Hg(lit.)
Density1.17 g/mL at 25 °C(lit.)
Refractive indexn20/D 1.642(lit.)
Flash point175 °F
Storage conditionsStore at <= 20°C.
SolubilityH2O: slightly solubleINSOLUBLE
pKa (acidity coefficient)pK1: <2(+1)pK2: 7.90(0) (25°C)
Physical stateLiquid
ColorClear yellow to amber
SensitivityStench
BRN606076
StabilityAir Sensitive
InChI1S/C6H7NS/c7-5-3-1-2-4-6(5)8/h1-4,8H,7H2
InChIKeyVRVRGVPWCUEOGV-UHFFFAOYSA-N
SMILESNc1ccccc1S
CAS DataBase Reference137-07-5(CAS DataBase Reference)
EWG's Food Scores1
FDA UNIIKIT82KOK2Z
NIST Chemistry ReferenceBenzenethiol, 2-amino-(137-07-5)
EPA Substance Registry SystemBenzenethiol, 2-amino- (137-07-5)
UNSPSC Code12352105
NACRESNA.22
GHS pictogramGHS05,GHS07,GHS08,GHS09
Signal wordDanger
GHS hazard statementsH302-H314-H341-H410
GHS precautionary statementsP501-P273-P270-P202-P201-P264-P280-P391-P308+P313-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Personal protective equipment (PPE)Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard symbolsC,N
Risk statements (R)22-34-50/53-37-20/21/22
Safety statements (S)26-36/37/39-45-60-61-25-27
UN transport numberUN 1760 8/PG 3
Water hazard class (WGK)3
RTECS numberDC0600000
F9-13-23
Hazard NoteCorrosive/Stench
TSCA inventory statusTSCA listed
Hazard class8Acute Tox. 4 OralAquatic Acute 1Eye Dam. 1Skin Corr. 1B
Packing groupIII
Customs code29309070
Storage class8A - Combustible corrosive hazardous materials
REACH registrationsActive
Limited quantities5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted quantitiesMax Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & Regulations

GHS classificationThis chemical does not meet GHS hazard criteria for 97% (2010 of 2073) of all reports.Not ClassifiedAggregated GHS information provided per 2073 reports by companies from 15 notifications to the ECHA C&L Inventory.WarningH227: Combustible liquid [Warning Flammable liquids]P210, P280, P370+P378, P403, and P501 (click each P-code to see the statement)
Regulatory informationChemical: Benzenethiol, 2-amino-Status: Active Update: 15-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/229012-Aminothiophenol: Does not have an individual approval but may be used under an appropriate group standard
Hazards summaryCauses methemoglobinemia in oral lethal-dose studies of rats[RTECS] Causes burnsMay cause skin sensitization and methemoglobinemiaInhalation may cause corrosive injuries to upper respiratory tract and lungsToxic by ingestionMay have cumulative effects[Alfa Aesar MSDS] See 2-Aminophenol.
Hazard Classes and CategoriesNot ClassifiedFlammable liquids - Category 4
Adverse effectsMethemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect
F9-13-23
Personal protective equipment (PPE)Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Water hazard class (WGK)3
TSCA inventory statusTSCA listed
RTECS numberDC0600000
UN transport numberUN 1760 8/PG 3
Customs code29309070
Risk statements (R)22-34-50/53-37-20/21/22
Signal wordDanger
GHS pictogramGHS05,GHS07,GHS08,GHS09
Hazard symbolsC,N
hazard_noteCorrosive/Stench
Safety statements (S)26-36/37/39-45-60-61-25-27
Hazard class8Acute Tox. 4 OralAquatic Acute 1Eye Dam. 1Skin Corr. 1B
Storage class8A - Combustible corrosive hazardous materials
Packing groupIII
GHS hazard statementsH302-H314-H341-H410
Limited quantities5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted quantitiesMax Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
REACH registrationsActive
GHS precautionary statementsP501-P273-P270-P202-P201-P264-P280-P391-P308+P313-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405

Applications & Uses

Uses

2-Aminothiophenol was used in the synthesis of 1,5-benzothiazepines derivatives by reacting with 1,3-diphenylpropenone derivatives and using aluminosilicate solid catalysts. It was also used in the synthesis of benzothiazole2 and 3-(benzothiazol-2-yl)coumarin derivatives. The ternary complexes of copper (II) with salicylidene-2-aminothiophenol (L) and glycine, alanine, valine and histidene amino acids.

Uses

A multifunctional compound which shows antioxidant activity in a skin cell model of UVA-induced stress.

Uses

2-Aminothiophenol was used in one-pot synthesis of stable phosphonium ylides. It was also used in the synthesis of 2-[(2-benzothiazolylmethyl)thio]-benzenamine. It was used to functionalize silver nano particles for biological pH sensing based on surface enhanced Raman scattering.

General Description

2-Aminothiophenol couples with Amberlite XAD by means of an N=N spacer to prepare a new functionalized resin for on-line preconcentration of copper and cadmium.