Basic information
- Standard SMILES
CSCCC(N)C(=O)O- InChIKey
FFEARJCKVFRZRR-UHFFFAOYSA-N- Molecular formula
- C5H11NO2S
- Average molar mass
- 149.21 g/mol
- Monoisotopic mass
- 149.05104977
Names & identifiers
- Preferred name
- (+-)-Methionine
- IUPAC
- 2-amino-4-methylsulfanylbutanoic acid
- English name
- POLY-L-METHIONINE
- Molecular formula
- C5H11NO2S
- Molecular weight
- 149.21
Names & synonyms
DL-METHIONINE59-51-8RacemethionineAcimetionLobamineUrimeth(+-)-MethionineDL-MethioninumMethionine, DL-2-amino-4-methylsulfanylbutanoic acid2-amino-4-(methylsulfanyl)butanoic acidFEMA No. 3301
Show more names
Nsc118113Poly(Met)polymethioninePOLY-L-METHIONINEPOLY-L-METHIONINE USP/EP/BP2-amino-4-methylsulfanylbutanoicaci
Methionine, amorphousMethionine DL-DL-2-Amino-4-(methylthio)-butyric acidDTXSID9020821NSC-924173JWT2K6T3DTXCID50821CHEBI:16811
Database identifiers
- CAS
26062-47-5、33807-07-7、348-67-4、59-51-8、63-68-3- PubChem CID
- 876
- DTXSID
DTXSID9020821- ChEMBL
CHEMBL274119- ChEBI
CHEBI:16811- UNII
- 73JWT2K6T3
- EC Number
- 200-432-1
- Nikkaji
- J1.286F
Properties
Computed structural properties
- XLogP
- -1.9
- Topological polar surface area
- 88.6 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 97
Experimental & physicochemical properties
DensityRelative density (water = 1): 1.3
Solubility
32.7 mg/mL at 25 °C
Solubility in water, g/100ml at 20 °C: 4.8
Soluble in water; Insoluble in ether
Soluble (in ethanol)
Boiling Point300.00 to 301.00 °C. @ 760.00 mm Hg
Decomposition281 °C
Melting Point281 °C
Physical Description
Solid; [Merck Index] Colorless or white solid; [ICSC] White powder; [Sigma-Aldrich MSDS]
Solid
COLOURLESS CRYSTALS OR WHITE POWDER.
White crystalline platelets or powder; Characteristic aroma
Physicochemical properties
- storage temp.
- -20 °C · -20°C
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 99% (197 of 199) of all reports.
Not Classified；Reported as not meeting GHS hazard criteria by 197 of 199 companies (only 1% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 199 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 197 of 199 reports by companies.；There are 2 notifications provided by 2 of 199 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: DL-Methionine
Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)
Methionine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methionine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Methionine: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - DL-Methionine: Human health tier I assessment；IMAP assessments - DL-Methionine: Environment tier I assessment
Fire HazardsGives off irritating or toxic fumes (or gases) in a fire.
Hazards Summary
Causes pigmented or nucleated red blood cells, changes in leukocyte counts, and changes in liver, bladder, and spleen weights in repeated-dose oral studies of rats; [RTECS] No listed effects of short-term or long-term exposure; [ICSC] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; [Sigma-Aldrich MSDS]
EPA Safer ChemicalChemical: DL-Methionine； Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
Chemical DangersDecomposes on heating. This produces toxic fumes of sulfur oxides and nitrous oxides.
Hazard Classes and CategoriesNot Classified
Safety & protection
Fire FightingUse water spray, powder, foam, carbon dioxide.
First Aid Measures
Fresh air, rest.
Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
Safe StorageSeparated from strong oxidants. Well closed.
Spillage DisposalSweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Eye PreventionWear safety spectacles.
Ingestion PreventionDo not eat, drink, or smoke during work.
Inhalation PreventionUse local exhaust.
Toxicology
Exposure RoutesThe substance can be absorbed into the body by ingestion.
Regulatory information
Regulatory Information
Chemical: DL-Methionine
Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)
Methionine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methionine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Methionine: Does not have an individual approval but may be used under an appropriate group standard
Chemistry & industry
Pharmacology
Cellular LocationsCytoplasm；Extracellular
Uses & manufacturing
UsesAn essential amino acid; Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier; [Merck Index] Used as a flavoring agent and nutritional supplement; [FDA]
U.S. Production2021: 246,400 lb
Industry UsesNot Known or Reasonably Ascertainable
Use Classification
EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers
Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
Flavoring Agents -> JECFA Flavorings Index
Cosmetics -> Antistatic; Hair conditioning; Skin conditioning
General Manufacturing Information
Not Known or Reasonably Ascertainable
Methionine: ACTIVE
Suppliers6 total
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
石家庄瑞田生化有限公司15831127780 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
DONBOO AMINO ACID COMPANY13063595538 · [email protected]
Dideu Industries Group Limited+8617392712697 · [email protected]
Additional notes
DefinitionChEBI: Methionine is a sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, a Daphnia magna metabolite and an algal metabolite. It is an alpha-amino acid and a sulfur-containing amino acid. It is functionally related to a butyric acid. It is a conjugate base of a methioninium. It is a conjugate acid of a methioninate. It is a tautomer of a methionine zwitterion.
Related reactions
88 records
Linked notes
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