Trisodium N-hydroxyethylethylenediaminetriacetate

Cosmetic ingredients (Trisodium HEDTA) -> CIR (Cosmetic Ingredient Review)

Chelating

1.285

1.285 @25 °C

Insoluble in most organic solvents

In water, 480 g/L at 20 °C

288 °C (hydate)

288 °C

Stability Constants [Table#5466]

Forms strong 1:1 ferric chelates which will then chelate other heavy metal or alkaline earth ions

Perma Kleer 120: Liquid form, 41% min. solids, with flash point >200 °F.

This chemical does not meet GHS hazard criteria for 0.2% (2 of 938) of reports.

Danger

H302 (30.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 938 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, trisodium salt

Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate) (EC: 205-381-9)

Glycine, N-2-bis(carboxymethyl)aminoethyl-N-(hydroxyethyl)-, trisodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Trisodium N-hydroxyethylethylenediaminetriacetate: Does not have an individual approval but may be used under an appropriate group standard

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Trisodium (2-hydroxyethyl)ethylenediaminetriacetate is found on List D. Case No: 4037; Pesticide type: fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): trisodium (2-hydroxyethyl)ethylenediaminetriacetate; AI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.

/Incompatible with/ oxidizing agents.

Reacts with aluminum, with evolution of hydrogen.

The affinity of HEDTA for divalent metal ions is similar to that of EDTA in the acid pH range, but metal chelates of HEDTA are much more susceptible to metal hydrolysis and other interferences in the alkaline pH range. /HEDTA/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

NIOSH (NOES Survey 1981-1983) has statistically estimated that 148,871 workers (72,162 of these were female) were potentially exposed to trisodium N-hydroxyethylethylenediaminetriacetate in the US(1). Occupational exposure to ethylenediamine tetraacetic acid may occur through dermal contact with this compound at workplaces where ethylenediamine tetraacetic acid is produced or used(SRC).

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Trisodium (2-hydroxyethyl)ethylenediaminetriacetate is found on List D. Case No: 4037; Pesticide type: fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): trisodium (2-hydroxyethyl)ethylenediaminetriacetate; AI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.

CIR ingredient: Trisodium HEDTA

For trisodium (2-hydroxyethyl)ethylenediaminetriacetate (USEPA/OPP Pesticide Code: 039109) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

... Hydroxyethyl Ethylenediamine Triacetic Acid (HEDTA) and its salt, Trisodium HEDTA, are substituted amines. These ingredients function as chelating agents in cosmetic formulations by combining with polyvalent metal cations in solution to form soluble ring structures.

The use of EDTA and its salts as stabilizing and chelating agents has been described as "ubiquitous". Originally, EDTA and the Edetates were developed to counteract the effects of hard water and heavy metal ions on dyestuffs used in textile manufacture. Currently, these ingredients are used in a wide number of applications. EDTA, HEDTA, and their salts maintain clarity, protect fragrance components, stabilize polymeric thickeners and color additives, prevent rancidity, and increase preservative effectiveness, among other effects.

As chelating agent for trivalent iron from pH 7 to pH10. Forms strong 1:1 ferric chelates. The iron chelates formed will then chelate other heavy metal or alkaline earth ions.

2023: 10,000,000 - <25,000,000 lb

Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, trisodium salt is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).[EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program. Glycine, N-[2-

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5467]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, sodium salt. Aggregated National Production Volume: 10 to < 50 million pounds.[US EPA; Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine, N-[2-

Versenol 120 (Dow). Trademark name for the trisodium salt of N-hydroxyetheyethylenediaminetriacetic acid.

Trilon D Liquid: 30.0 - 60.0 % Trisodium HEDTA; 1.0 - 5.0 % Sodium Hydroxide; 1.0 - 5.0 % trisodium nitrilotriacetate

Oil and Gas Drilling, Extraction, and Support activities

Glycine, N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-, sodium salt (1:3): ACTIVE

Sour water is stripped with air in a tower to remove hydrogen sulfide, the evolved gas is scrubbed with an aqueous chelated Fe3+ solution in an upper portion of the tower to absorb the H2S and oxidize it to sulfur, and the treated gas is discharged from the top of the tower. A suitable solution for scrubbing consists of water 2400, 39% FeCl3 577, Na4EDTA 272, trisodium-n(2-hydroxyethyl)ethylenediaminetriacetate 272, 70% sorbitol 272, 50% NaOH 153, and Na2CO3 350 g.