Basic information
- CAS
80277-11-8- Standard SMILES
CC(O)C(=O)O.COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12- InChIKey
NYGZSXVEKMITFN-UHFFFAOYSA-N- Molecular formula
- C24H25N3O6S
- Average molar mass
- 483.5 g/mol
- Monoisotopic mass
- 483.1464067
Overview
Amsacrine Lactate is the lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks. This ultimately induces programmed cell death.
Names & identifiers
- Preferred name
- Amsacrine Lactate
- IUPAC
- N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;2-hydroxypropanoic acid
- English name
- N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide: 2-hydrox ypropanoic acid
- Molecular formula
- C24H25N3O6S
- Molecular weight
- 0
Names & synonyms
Amsacrine lactate80277-11-8m-AMSA lactate959PWE0Q2EUNII-959PWE0Q2EMethanesulfonamide, N-(4-(9-acridinylamino)-3-methoxyphenyl)-, mono(2-hydroxypropanoate)NSC141549RefChem:112359NSC 141549N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamideN-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;2-hydroxypropanoic acidorb1740808
Show more names
Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with lactic acidN-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with lactic acidN-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide: 2-hydrox ypropanoic acidPropanoic acid, 2-hydroxy-, compd. with N-(4-(9-acridinylamino)-3-methoxyphenyl)methanesulfonamide (1:1)
SCHEMBL3497923DTXSID701001137T68672Q272717692-Hydroxypropanoic acid--N-{4-[(acridin-9(10H)-ylidene)amino]-3-methoxyphenyl}methanesulfonamide (1/1)
Properties
Computed structural properties
- Topological polar surface area
- 146 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 6
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 660
Physicochemical properties
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 959 PWE0Q2E · 959PWE0Q2E
Chemistry & industry
Suppliers3 total
上海陶术生物科技股份有限公司13564774135 · [email protected]
湖北玖天生物医药科技有限公司027-88013699 17354350817 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…