Diisobutyl Adipate

0.9534 g/cu cm @ 19 °C

0.950-0.956 (20 °C)

Sol in most org solvents; insol in water

Practically insoluble or insoluble in water

Soluble (in ethanol)

278-280 °C

BP: 186-8 °C @ 15 mm Hg

279.00 °C. @ 760.00 mm Hg

280-281 °C

-20 °C

-20.00 °C. @ 760.00 mm Hg

Index of refraction: 1.4301 @ 20 °C

1.428-1.434

Liquid

Colorless odorless liquid; [Hawley]

Clear colourless liquid; Bland aroma

1660；1655；1656；1656；1657；1652；1666.5；1660

1691；1699；1680；1699

2132；2119

179.8 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9036690]

235.89 Ų [2M+Na]+；218.46 Ų [M+Na]+；180.16 Ų [M+Na]+；294.67 Ų [2M+Na]+；167.82 Ų [M+H]+

This chemical does not meet GHS hazard criteria for 99.7% (339 of 340) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 339 of 340 companies (only 0.3% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 340 reports by companies from 3 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 339 of 340 reports by companies.；There is 1 notification provided by 1 of 340 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Hexanedioic acid, bis(2-methylpropyl) ester

Hexanedioic acid, 1,6-bis(2-methylpropyl) ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hexanedioic acid, 1,6-bis(2-methylpropyl) ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 26-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23508

Hexanedioic acid, bis(2-methylpropyl) ester: Does not have an individual approval but may be used under an appropriate group standard

Increased malformations in fetal rats after treatment of pregnant animals on days 5, 10, and 15 with 1.9 mL/kg; [REPROTOX] Intraperitoneal TDLo (rat) = 595 mg/kg (5-15D preg) for developmental abnormalities; Intraperitoneal LD50 (rat) = 5950 uL/kg; [RTECS] May cause irritation; [MSDSonline]

Diisobutyl adipate is an indirect food additive for use only as a component of adhesives.

Prior-Sanctioned Food Ingredients: Substances classified as plasticizers, when migrating from food-packaging material shall include: diisobutyl adipate.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

DIISOBUTYL ADIPATE WAS LESS TERATOGENIC IN RATS THAN COMPARABLE PHTHALATES WHEN ADMIN DURING GESTATION IN EQUIV FRACTIONS OF RESP LD50 DOSES.

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Experimental teratogenic effects.

/SRP:/ Basic Treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use propaparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

Chemical: Hexanedioic acid, bis(2-methylpropyl) ester

Hexanedioic acid, 1,6-bis(2-methylpropyl) ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hexanedioic acid, 1,6-bis(2-methylpropyl) ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 26-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23508

Hexanedioic acid, bis(2-methylpropyl) ester: Does not have an individual approval but may be used under an appropriate group standard

Diisobutyl adipate is an indirect food additive for use only as a component of adhesives.

Prior-Sanctioned Food Ingredients: Substances classified as plasticizers, when migrating from food-packaging material shall include: diisobutyl adipate.

CIR ingredient: Diisobutyl Adipate

Used as plasticizer; [Hawley]

Plasticizer

2023: 100,000 - <250,000 lb；2022: 100,000 - <250,000 lb；2021: 50,000 - <75,000 lb；2020: <25,000 lb

(1986) No Data

EPA Safer Chemical Functional Use Classes -> Solvents

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Cosmetics -> Emollient

Paint and Coating Manufacturing；Textiles, apparel, and leather manufacturing

Hexanedioic acid, 1,6-bis(2-methylpropyl) ester: ACTIVE

Compatible with most natural and synthetic polymers.