Bis(2-(2-butoxyethoxy)ethyl) adipate

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1,400(SRC), determined from an estimated log Kow of 3.24(2,SRC) and a regression-derived equation(3), indicates that bis(2-(2-butoxyethoxy)ethyl) adipate is expected to have low mobility in soil(SRC). Volatilization of bis(2-(2-butoxyethoxy)ethyl) adipate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.1X10-13 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Bis(2-(2-butoxyethoxy)ethyl) adipate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.8X10-8 mm Hg(SRC), determined from a fragment constant method(5). Bis(2-(2-butoxyethoxy)ethyl) adipate, present at 100 mg/l, achieved 86 percent of its theoretical BOD in 4 weeks using an activated sludge inoculum(6), suggesting this compound may biodegrade in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1,400(SRC), determined from an estimated log Kow of 3.24(2,SRC) and a regression-derived equation(3), indicates that bis(2-(2-butoxyethoxy)ethyl) adipate is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected to be an important fate process(3) based upon an estimated Henry's Law constant of 3.1X10-13 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). A base-catalyzed second-order hydrolysis rate constant of 0.27 L/mole-sec(SRC) was estimated using a structure estimation method(5); this corresponds to half-lives of 294 and 29 days at pH values of 7 and 8, respectively(5). According to a classification scheme(6), an estimated BCF of 62(SRC), from an estimated log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Bis(2-(2-butoxyethoxy)ethyl) adipate, present at 100 mg/l, achieved 86 percent of its theoretical BOD in 4 weeks using an activated sludge inoculum(8), suggesting this compound may biodegrade in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(2-(2-butoxyethoxy)ethyl) adipate, which has an estimated vapor pressure of 9.8X10-8 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(2-(2-butoxyethoxy)ethyl) adipate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 7.4X10-11 cu cm/molecule-sec at 25 °C(3) determined using a structure estimation method(3). Bis(2-(2-butoxyethoxy)ethyl) adipate may also undergo direct photolysis in the environment since this compound contains a functional group that can absorb light greater than 290 nm(4). Particulate-phase bis(2-(2-butoxyethoxy)ethyl) adipate may be removed from the air by wet and dry deposition(SRC).

The Koc of bis(2-(2-butoxyethoxy)ethyl) adipate is estimated as 1,400(SRC), using an estimated log Kow of 3.24(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bis(2-(2-butoxyethoxy)ethyl) adipate is expected to have low mobility in soil(SRC).

An estimated BCF of 62 was calculated for bis(2-(2-butoxyethoxy)ethyl) adipate(SRC), using an estimated log Kow of 3.24(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Henry's Law constant for bis(2-(2-butoxyethoxy)ethyl) adipate is estimated as 3.1X10-13 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that bis(2-(2-butoxyethoxy)ethyl) adipate is expected to be essentially nonvolatile from water surfaces(2). Bis(2-(2-butoxyethoxy)ethyl) adipate's estimated Henry's Law constant(1) indicates that volatilization from moist soil surfaces is not expected(SRC). Volatilization from dry soil surfaces is not expected to be an important environmental fate process given an estimated vapor pressure of 9.8X10-8 mm Hg at 25 °C(3).

The rate constant for the vapor-phase reaction of bis(2-(2-butoxyethoxy)ethyl) adipate with photochemically-produced hydroxyl radicals has been estimated as 7.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.27 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 294 and 29 days at pH values of 7 and 8, respectively(2). Bis(2-(2-butoxyethoxy)ethyl) adipate may also undergo direct photolysis in the environment since this compound contains a functional group that can absorb light greater than 290 nm(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,476 workers (75 of these are female) are potentially exposed to bis(2-(2-butoxyethoxy)ethyl) adipate in the US(1). Occupational exposure to bis(2-(2-butoxyethoxy)ethyl) adipate may occur through inhalation and dermal contact with this compound at workplaces where bis(2-(2-butoxyethoxy)ethyl) adipate is produced or used(SRC).

Bis(2-(2-butoxyethoxy)ethyl) adipate's production and use as a plasticizer may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 9.8X10-8 mm Hg at 25 °C indicates bis(2-(2-butoxyethoxy)ethyl) adipate will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(2-(2-butoxyethoxy)ethyl) adipate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 hours. Bis(2-(2-butoxyethoxy)ethyl) adipate may also undergo direct photolysis in the environment, but the kinetics of this reaction are unknown. Particulate-phase bis(2-(2-butoxyethoxy)ethyl) adipate will be removed from the atmosphere by wet and dry deposition. If released to soil, bis(2-(2-butoxyethoxy)ethyl) adipate is expected to have low mobility based upon an estimated Koc of 1,400. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 3.1X10-13 atm-cu m/mole. Bis(2-(2-butoxyethoxy)ethyl) adipate is not expected to volatilize from dry soil surfaces based on its vapor pressure. Bis(2-(2-butoxyethoxy)ethyl) adipate, achieved 86 percent of its theoretical BOD in 4 weeks using an activated sludge inoculum, suggesting this compound may biodegrade in the environment. If released into water, bis(2-(2-butoxyethoxy)ethyl) adipate is expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Hydrolysis may be an important environmental fate process based on estimated hydrolysis half-lives of 29 and 294 days at pH 8 and 7, respectively. An estimated BCF of 62 suggests the potential for bioconcentration in aquatic organisms is moderate. Occupational exposure to bis(2-(2-but

Chemical: Hexanedioic acid, 1,6-bis[2-(2-butoxyethoxy)ethyl] ester

Hexanedioic acid, 1,6-bis[2-(2-butoxyethoxy)ethyl] ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hexanedioic acid, 1,6-bis[2-(2-butoxyethoxy)ethyl] ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 25-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12122