CAS 142-26-7 Acetylethanolamine (HCID 8880)

Overview

N-acetylethanolamine is a member of the class of ethanolamines that is 2-aminoethanol in which one of the hydrogens of the amino group is replaced by an acetyl group. It has a role as a metabolite. It is a member of acetamides, a member of ethanolamines and a monocarboxylic acid amide.

Names & identifiers

Preferred name: Acetylethanolamine
IUPAC: N-(2-hydroxyethyl)acetamide
English name: 2-Acetylaminoethanol
Molecular formula: C4H9NO2
Molecular weight: 103.12

Names & synonyms

N-(2-Hydroxyethyl)acetamideN-Acetylethanolamine142-26-72-AcetamidoethanolAcetylcolamineAcetamide, N-(2-hydroxyethyl)-Acetamide MEA2-AcetylaminoethanolN-EthanolacetamideN-Acetyl-2-aminoethanolHydroxyethyl acetamideN-Acetyl ethanolamine

Show more names

Amidex AMEHetamide MALipamide MEAAUpamide ACMEAFoamid AME-70Foamid AME-75

ACETYLETHANOLAMINEN-2-HydroxyethylacetamideAcetic monoethanolamidebeta-HydroxyethylacetamideN-beta-HydroxyethylacetamideNSC 5999DTXSID6044804HSDB 2713

Database identifiers

CAS: 142-26-7
PubChem CID: 8880
DTXSID: DTXSID6044804
ChEMBL: CHEMBL3188272
ChEBI: CHEBI:74687
UNII: A9O0818TWD
EC Number: 205-530-8
Nikkaji: J2.542I

Properties

Computed structural properties

XLogP: -1.1
Topological polar surface area: 49.3 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 2
Heavy atoms: 7
Formal charge: 0
Complexity: 62.7

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Ethanolamines

Cosmetics · 2 items

Cosmetic ingredients (Acetamide MEA) -> CIR (Cosmetic Ingredient Review)

Humectant; Antistatic

SpringerMaterials PropertiesDielectric constant

Density1.1079 @ 25 °C/4 °C

Color/Form · 2 items

NEEDLES (ACETONE)

BROWN, VISCOUS LIQUID

SolubilitySOL IN ALL PROP IN WATER; SOL IN HOT ACETONE; SLIGHTLY SOL IN BENZENE, PETROLEUM ETHER

Physicochemical properties

Melting point: 15.8 °C · 15.8 °C
Boiling point: 151 · 151-155 °C/5 mmHg (lit.)
Density: 1.12 g/mL · 1.12 g/mL at 25 °C (lit.)
vapor pressure: 0.368 · 0.368-10.5Pa at 25-70℃
refractive index: 20 · n20/D 1.472(lit.)
Flash point: 350 °F · 350 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 14.56 · 14.56±0.10(Predicted)
form: Liquid
color: Clear white to yellow
Water Solubility: 1 e+006 · Soluble in water, 1e+006 mg/L @ 25°C (est), soluble in alcohol and ether.
Cosmetics Ingredients Functions: SURFACTANT - CLEANSINGHAIR CONDITIONINGHUMECTANTSKIN CONDITIONINGSURFACTANT - FOAM BOOSTINGVISCOSITY CONTROLLING
Cosmetic Ingredient Review (CIR): 2 · 2-Acetylaminoethanol (142-26-7)
InChI: 1S/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7)
InChIKey: PVCJKHHOXFKFRP-UHFFFAOYSA-N
SMILES: CC(=O)NCCO
LogP: -0.117 at · -0.117 at 22.2℃ and pH5.4
Surface tension: 72.1 mN/m · 72.1mN/m at 1g/L and 21.4℃
CAS DataBase Reference: 142 · 142-26-7(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: 2 · 2-ACETAMIDOETHANOL
FDA 21 CFR: 175.105 · 175.105
EWG's Food Scores: 1 · 1
FDA UNII: 9 O0818TWD · A9O0818TWD
NIST Chemistry Reference: Acetamide, N-(2-hydroxyethyl)-(142-26-7)
EPA Substance Registry System: Acetamide, N-(2-hydroxyethyl)- (142-26-7)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS07
Signal word: Danger
Hazard statements: 315 · H315-H318-H335
Precautionary statements: 261 · P261-P280-P305+P351+P338
target organs: Respiratory system
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-41-37/38
Safety Statements: 26 · 26-36
WGK Germany: 2 · 2
RTECS: 3120000 · AC3120000
TSCA: TSCA listed
HS Code: 29241990 · 29241990
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Irrit. 2STOT SE 3
Hazardous Substances Data: 142 · 142-26-7(Hazardous Substances Data)
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 40% (32 of 80) of reports.

Danger

H315 (51.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 4 items

Chemical: Acetamide, N-(2-hydroxyethyl)-

Acetamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/24151

Acetylethanolamine: Does not have an individual approval but may be used under an appropriate group standard

Fire PotentialSLIGHT, WHEN EXPOSED TO HEAT OR FLAME.

Hazards SummaryEmergency treatment: Ethanolamine; Ethanolamine can cause CNS depression, skin burns, and acute injury to the kidneys, liver, and lungs; [HSDB] An irritant; May cause serious eye injury; [MSDSonline]

NFPA Hazard Classification · 3 items

1 - Materials that, under emergency conditions, can cause significant irritation.

1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.

0 - Materials that in themselves are normally stable, even under fire conditions.

Hazard Classes and CategoriesSkin Irrit. 2 (51.2%)

Safety & protection

Fire Fighting ProceduresWATER, FOAM, ALCOHOL FOAM, CARBON DIOXIDE, DRY CHEMICAL...

Storage Conditions · 1 item

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

Toxicology

Adverse EffectsNeurotoxin - Other CNS neurotoxin

Toxicity Summary · 2 items

The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Acetamide MEA

Safe for use in cosmetics, with qualifications

Non-Human Toxicity Excerpts · 3 items

HYDROXYETHYL ACETAMIDE RATED 3 ON RABBIT EYES. /TESTED EXTERNALLY ON EYES OF RABBITS & HAVE BEEN RATED NUMERICALLY ON SCALE OF 1 TO 10 ACCORDING TO DEGREE OF INJURY OBSERVED AFTER 24 HR, PAYING PARTICULAR ATTENTION TO CONDITION OF CORNEA. MOST SEVERE INJURIES HAVE BEEN RATED 10./

WHEN INJECTED IV INTO RABBITS FOR 7 DAYS, N-ACETYLETHANOLAMINE (30-34 MG/G/DAY) DECR ASPARTATE LEVEL IN BRAIN & KIDNEY. ADMIN IN SINGLE INJECTION, N-ACETYLETHANOLAMINE INCR LEVELS OF GLUTAMATE, ASPARTATE, & GABA IN BRAIN.

N-ACETYLETHANOLAMINE (42 MG/KG) GIVEN IP TO RATS INCR GLYCOGEN & ATP IN LIVER, KIDNEYS, BRAIN, & HEART.

Safety data

PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 2
tsca: TSCA listed
rtecs: AC3120000
hs_code: 29241990
risk_code: 36/37/38-41-37/38
Signal word: Danger
Symbol(GHS): GHS05,GHS07
hazard_code: Xi
safety_code: 26-36
Storage Class: 10 - Combustible liquids
target organs: Respiratory system
Hazard statements: H315-H318-H335
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P280-P305+P351+P338
Hazardous Substances Data: 142-26-7(Hazardous Substances Data)

Chemistry & industry

Uses & manufacturing

Uses · 3 items

CIR ingredient: Acetamide MEA

Used as a plasticizer, humectant (paper products, glues, cork, and inks), and textile conditioner; [Hawley]

Pulp and Paper Processing [Category: Industry]

U.S. Production2023: 72,722 lb

Consumer UsesHumectant

Household ProductsInformation on 60 consumer products that contain Acetamide MEA in the following categories is provided:

Use ClassificationCosmetics -> Humectant; Antistatic

General Manufacturing InformationAcetamide, N-(2-hydroxyethyl)-: ACTIVE

Applications · 2 items

UsesIt finds its uses as antistatic agent, foam boosting agent, hair conditioning humectant, skin conditioning surfactant and viscosity controlling agent in cosmetics industry. It is a non-tacky glycerine alternative for use in skin and hair care. It has humectant and lubricant properties for use in shampoos, treatment products and hair conditioners.

Uses2-Acetylaminoethanol is a humectant recommended for use in emulsions.

Upstream & downstream products

Upstream raw materials

Monoethanolamine

Downstream products

N,N-Bis(2-hydroxyethyl)acetamide Acetamide, N-(2-oxoethyl)-Acetamide,N-[2-(4-nitrophenoxy)ethyl]-

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

湖北永阔科技有限公司027-59223108 15972152991 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

湖北万得化工有限公司15377098680 15377098680 · [email protected]

Additional notes

DefinitionChEBI: A member of the class of ethanolamines that is 2-aminoethanol in which one of the hydrogens of the amino group is replaced by an acetyl group.