Tetraglyme
Basic information
- CAS
143-24-8- Standard SMILES
COCCOCCOCCOCCOC- InChIKey
ZUHZGEOKBKGPSW-UHFFFAOYSA-N- Molecular formula
- C10H22O5
- Average molar mass
- 222.28 g/mol
- Monoisotopic mass
- 222.1467238
Overview
Tetraglyme is a polyether.
Names & identifiers
- Preferred name
- Tetraglyme
- IUPAC
- 1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane
- English name
- Dimethoxytetraglycol
- Molecular formula
- C10H22O5
- Molecular weight
- 222.27868
Names & synonyms
Tetraglyme143-24-8Tetraethylene glycol dimethyl ether2,5,8,11,14-PENTAOXAPENTADECANEDimethoxytetraethylene glycolGlyme 5Ansul ether 181ATDimethoxytetraglycolBis[2-(2-methoxyethoxy)ethyl] etherNissan uniox MM 200Methyltetraglyme200DTXSID7044396
Show more names
E181 (Ether)Bis(2-(2-methoxyethoxy)ethyl) ether78L136FLZ9NSC-65624DTXCID5024396CHEBI:46785RefChem:188598205-594-7
Database identifiers
- CAS
143-24-8- PubChem CID
- 8925
- DTXSID
DTXSID7044396- ChEMBL
CHEMBL3182543- ChEBI
CHEBI:46785- UNII
- 78L136FLZ9
- EC Number
- 205-594-7
- Nikkaji
- J5.817C
Properties
Computed structural properties
- XLogP
- -0.7
- Topological polar surface area
- 46.2 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 12
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 98
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
SolventsSolvents -> Glycol Ethers (Glymes)
SpringerMaterials PropertiesBoiling point
SurfactantsSurfactant
Physical Description
Liquid; Liquid; Wet Solid
Liquid; [Merck Index] Clear colorless liquid; [Sigma-Aldrich MSDS]
Collision Cross Section147.3 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID7044396]
Physicochemical properties
- Boiling point
- 275 · 275-276°C
- Density
- 1.009 · 1.009
- form
- A liquid
- Substances of Very High Concern (SVHC) Candidate List
- Bis(2-(2-methoxyethoxy)ethyl)ether (143-24-8)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
This chemical does not meet GHS hazard criteria for 14.4% (71 of 494) of reports.
Danger
H360 (54.3%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Hazard information
Regulatory Information
Chemical: 2,5,8,11,14-Pentaoxapentadecane
Hazard Traits - Reproductive Toxicity
2,5,8,11,14-Pentaoxapentadecane is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2,5,8,11,14-Pentaoxapentadecane are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
SP - indicates a substance that is identified in a proposed Significant New Use Rule.
Status: Active Update: 05-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14547
Substance: Bis(2-(2-methoxyethoxy)ethyl)ether
Other Safety InformationEvaluation - 2,5,8,11,14-Pentaoxapentadecane (tetraglyme)
Hazards Summary
A mild eye irritant; Causes somnolence and GI, kidney, and bladder changes in oral lethal-dose studies of rats; [RTECS] May form explosive peroxides on prolonged storage or contact with air; An eye irritant; [Sigma-Aldrich MSDS] See Monoglyme.
Peroxide Forming Chemical
Tetraethylene glycol dimethyl ether
D: Other compounds that may form peroxides
Kelly
Chemistry & industry
Uses & manufacturing
UsesUsed as a solvent; [Merck Index]
U.S. Production2023: 75,000 - <100,000 lb
Consumer UsesSolvent
Industry UsesFlux agent
General Manufacturing Information
Petroleum Lubricating Oil and Grease Manufacturing
2,5,8,11,14-Pentaoxapentadecane: ACTIVE
Additional notes
DefinitionChEBI: Tetraglyme is a polyether.
Related reactions
33 records
Compound notes
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