HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexadecylamine
HDA · HEXADECYLAMINE · HAD · CETYLAMINE · Hexadecan-1-amine · N-HEXADECYLAMINE · 1-Hexadecanamine · Armeen 16
Identifiers & Physical Properties
| CAS No. | 143-27-1 |
|---|---|
| Molecular formula | C16H35N |
| Average molar mass | 241.46 g/mol |
| Monoisotopic mass | 241.27695012 g/mol |
| SMILES | CCCCCCCCCCCCCCCCN |
| InChIKey | FJLUATLTXUNBOT-UHFFFAOYSA-N |
| PubChem CID | 8926 |
| ChEMBL | CHEMBL1534653 |
| ChEBI | CHEBI:165594 |
| EC No. | 205-596-8 |
| DTXSID | DTXSID7025390 |
Chemical & Physical Properties
| XLogP | 7.4 |
|---|---|
| Topological polar surface area | 26 |
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 1 |
| Rotatable bonds | 14 |
| Heavy atoms | 17 |
| Formal charge | 0 |
| Complexity | 123 |
| Chemical classes | Nitrogen Compounds -> Amines, Aliphatic |
| Cosmetics | Antistatic |
| SpringerMaterials Properties | Boiling point |
| Density | 0.8129 at 68 °F (NTP, 1992) - Less dense than waterwill float0.8129 @ 20°C0,813 g/cm3 |
| Solubility | less than 1 mg/mL at 72 °F (NTP, 1992)insoluble |
| Flash point | 285 °F (NTP, 1992) |
| Boiling point | 613 °F at 760 mmHg (NTP, 1992)322.5 °C @760 [mm Hg]330 °C (lit.) |
| Melting point | 115.2 °F (NTP, 1992)43-45 °C (lit.) |
| Physical Description | Hexadecylamine is a white solid. (NTP, 1992)White waxy solid with an ammoniacal odor[CAMEO] White crystalline solid with a weak odor[Alfa Aesar MSDS] |
| Vapor pressure | <1 mm Hg ( 20 °C) |
| Refractive index | 1.4496 |
| Storage conditions | Store below +30°C. |
| pKa (acidity coefficient) | 10.63(at 25℃) |
| Physical state | Low Melting Crystalline Mass or Chunks |
| Color | White |
| BRN | 1634065 |
| Cosmetics Ingredients Functions | ANTISTATIC |
| InChI | 1S/C16H35N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h2-17H2,1H3 |
| InChIKey | FJLUATLTXUNBOT-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCN |
| LogP (partition coefficient) | 6.73 at 25℃ |
| CAS DataBase Reference | 143-27-1(CAS DataBase Reference) |
| EWG's Food Scores | 1-2 |
| FDA UNII | O2H0Q02M4P |
| NIST Chemistry Reference | 1-Hexadecanamine(143-27-1) |
| EPA Substance Registry System | Hexadecylamine (143-27-1) |
| UNSPSC Code | 12352116 |
| NACRES | NA.22 |
| GHS pictogram | GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H304-H373-H410 |
| GHS precautionary statements | P273-P301+P310+P331-P314 |
| Target organs | Gastrointestinal tract,Liver,Immune system |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard symbols | C,Hazard |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
| UN transport number | UN 3259 8/PG 2 |
| Water hazard class (WGK) | 2 |
| RTECS number | ML9100000 |
| F | 34 |
| TSCA inventory status | TSCA listed |
| Hazard class | 8Aquatic Acute 1Aquatic Chronic 1Asp. Tox. 1Eye Dam. 1Skin Corr. 1ASTOT RE 2 |
| Packing group | III |
| Customs code | 29211980 |
| Storage class | 8A - Combustible corrosive hazardous materials |
| Toxicity | mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD691-490, |
| REACH registrations | Active |
| Limited quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
Safety & Regulations
| GHS classification | DangerH314 (98%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P264, P264+P265, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 50 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| Regulatory information | Chemical: 1-HexadecanamineStatus: Active Update: 30-09-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/29504Hexadecylamine: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Primary aliphatic (C12-22) and fatty amines: Human health tier II assessment |
| DOT label | Corrosive |
| Fire hazards | This chemical is combustible. (NTP, 1992) |
| Health hazards | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Hazards summary | May cause skin, eye, and mucous membrane irritation[CAMEO] Causes burnsInhalation may cause corrosive injuries to upper respiratory tract and lungs[Alfa Aesar MSDS] See Decylamine. |
| Reactive group | Amines, Phosphines, and Pyridines |
| Reactivity Profile | HEXADECYLAMINE may react with oxidizing agents (NTP, 1992). Readily neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Air and Water Reactions | This compound may be sensitive to prolonged exposure to air. Insoluble in water. |
| Hazard Classes and Categories | Skin Corr. 1 (98%)Acute toxicity - category 4 |
| Fire fighting | Fires involving this chemical can be controlled with a CO2, dry chemical, or Halon extinguisher. (NTP, 1992) |
| First aid | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Nonfire spill response | SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Protective Action Criteria (PAC) | 0.66 [mg/m3]7.2 [mg/m3]43 [mg/m3] |
| Personal Protective Equipment (PPE) | MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. |
| Adverse effects | Dermatotoxin - Skin burns. |
| F | 34 |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | ML9100000 |
| UN transport number | UN 3259 8/PG 2 |
| Customs code | 29211980 |
| Toxicity | mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD691-490, |
| Risk statements (R) | 34 |
| Signal word | Danger |
| GHS pictogram | GHS08,GHS09 |
| Hazard symbols | C,Hazard |
| Safety statements (S) | 26-36/37/39-45 |
| Hazard class | 8Aquatic Acute 1Aquatic Chronic 1Asp. Tox. 1Eye Dam. 1Skin Corr. 1ASTOT RE 2 |
| Storage class | 8A - Combustible corrosive hazardous materials |
| Packing group | III |
| Target organs | Gastrointestinal tract,Liver,Immune system |
| GHS hazard statements | H304-H373-H410 |
| Limited quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
| REACH registrations | Active |
| GHS precautionary statements | P273-P301+P310+P331-P314 |
Applications & Uses
Uses
Dental caries prophylactic.
Uses
1-Hexadecylamine is used for producing resin, senior detergent, anti-caking agent.
General Description
A white waxy solid with an ammonia-like odor. Insoluble in water and less dense than water. Hence floats on water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals.