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Methylarsonic acid

HCID 8948
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Substructure searchFind similar structures

Basic information

CAS
124-58-3
Standard SMILES
C[As](=O)(O)O
InChIKey
QYPPRTNMGCREIM-UHFFFAOYSA-N
Molecular formula
CH3AsO(OH)2
Average molar mass
139.97 g/mol
Monoisotopic mass
139.945464

Overview

Methylarsonic acid is an organoarsonic acid, a member of arsonic acids and a one-carbon compound. It is a conjugate acid of a methylarsonate(1-).

Names & identifiers

Preferred name
Methylarsonic acid
IUPAC
methylarsonic acid
English name
Methylarsonic acid
Molecular formula
CH5AsO3
Molecular weight
139.97

Names & synonyms

Methylarsonic acid124-58-3Monomethylarsonic acidArsonic acid, methyl-METHANEARSONIC ACIDMethylarsinic acidMonomethylarsinic acidMethylarsenic acidKyselina methylarsonovaDSMA (JMAF)MeAsO(OH)2J37VJ5709S
Show more names
C07294methylarsonicmethyl-arsonicacimethylarsinicacidmethylarsenicacidmethanearsonicacidmonomethylarsonicacid
DTXSID4020903CHEBI:29852RefChem:818523DTXCID80903204-705-6MonomethylarsonateMethylarsonic acid [ISO]methyl Arsonic acid

Database identifiers

CAS
124-58-3
PubChem CID
8948
DTXSID
DTXSID4020903
ChEMBL
CHEMBL1743208
ChEBI
CHEBI:29852
UNII
J37VJ5709S
EC Number
204-705-6

Properties

Computed structural properties

Topological polar surface area
57.5 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
3
Rotatable bonds
0
Heavy atoms
5
Formal charge
0
Complexity
61.3

Experimental & physicochemical properties

Chemical ClassesMetals -> Arsenic Compounds, Organic
TastePleasant acid taste
Color/Form · 3 items

Monoclinic, spear-shaped plates from absolute alcohol

White, crystalline solid

LEAVES FROM ALCOHOL

Solubility · 3 items

Soluble in ethanol

In water, 2.56X10+5 mg/l @ 20 °C.

Solubility in water: very good

CorrosivityMildly corrosive
DecompositionWHEN HEATED TO DECOMPOSITION IT EMITS TOXIC FUMES OF /ARSENIC/.
Melting Point · 2 items

160.5 °C

161 °C

Vapor Pressure · 2 items

0.00162 [mmHg]

<7.5X10-8 mm Hg @ 25 °C

Physical Description · 3 items

White hygroscopic solid; [ICSC]

Solid

WHITE HYGROSCOPIC SOLID IN VARIOUS FORMS.

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Hazard Traits - Carcinogenicity

Hazard Traits - Carcinogenicity; Cardiovascular Toxicity; Dermatotoxicity; Developmental Toxicity; Neurotoxicity; Other Toxicological Hazard Traits; Respiratory Toxicity

Restricted substance: Methylarsonic acid

Fire HazardsNot combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Hazards Summary · 1 item

Oral LD50 (rat) = 961 mg/kg; [Sax] A mild skin, eye, and respiratory tract irritant; May cause kidney and liver injury; [ICSC] After ingestion of arsenic-rich wine, the majority of the arsenic was excreted in the urine in methylated form (methylarsonic acid & dimethylarsinic acid); Methylarsonic acid (MAA) fed to dairy cows in cottonseed ration had no apparent adverse effects; MAA was poorly absorbed and rapidly excreted in the urine; [HSDB] Arsenic is a known teratogen, but the effects of organic arsenicals is less clear. MAA is not likely to be a reproductive hazard at levels currently found in the environment; [REPROTOX] An irritant; [MSDSonline]

EC ClassificationSymbol: T, N; R: 23/25-50/53; S: (1/2)-20/21-28-45-60-61; Note: A, 1
UN ClassificationUN Hazard Class: 6.1; UN Pack Group: I

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 6 items

AFTER INGESTION /SRP: BY HUMANS/ OF ARSENIC-RICH WINE, APPROX 10% OF THE ARSENIC WAS EXCRETED AS ARSENITE, BUT THE MAJORITY OF ARSENIC WAS METHYLATED TO METHYLARSONIC ACID & DIMETHYLARSINIC ACID & EXCRETED.

IN THE PRESENCE OF CECAL CONTENT, BUT NOT SMALL INTESTINE, SMALL AMOUNTS OF METHYLARSONIC ACID & DIMETHYLARSINIC ACID WERE FORMED BY THE RAT IN VITRO.

IN FIRST VOID URINE SAMPLES FROM COPPER SMELTER WORKERS EXPOSED TO INORG ARSENIC & FROM NONEXPOSED CONTROLS 20% OF TOTAL ARSENIC WAS EXCRETED AS METHYLARSONIC ACID.

THE HUMAN ORGANISM CAN COPE WITH MODERATE DOSES OF ARSENIC BY A RAPID & EFFICIENT METHYLATION PROCESS GIVING MONOMETHYLARSONIC ACID & DIMETHYLARSINIC ACID WHICH ARE RAPIDLY ELIMINATED IN THE URINE.

For more Metabolism/Metabolites (Complete) data for METHANEARSONIC ACID (6 total), please visit the HSDB record page.

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

MeSH Pharmacological Classification · 2 items

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.

An agent that causes the production of physical defects in the developing embryo.

Absorption, Distribution and Excretion · 3 items

...DAIRY COWS /WERE FED/ COTTONSEED RATION CONTAINING MAA. THE MAA HAD NO EFFECT ON COWS, WITH VERY LITTLE RESIDUE ACCUMULATING IN TISSUES OR MILK. THE MAA APPEARED TO BE POORLY ABSORBED FROM INTESTINAL TRACT & WAS RAPIDLY EXCRETED IN URINE.

ARSENIC CONTENT OF MILK OR EDIBLE TISSUES OF COWS FED FOR 9 WK WITH 5 LB COTTONSEED MEAL CONTAINING 30 PPM OF ACID WAS NOT SIGNIFICANTLY INCREASED; NOR WAS ARSENIC CONTENT OF EGGS AND MEAT OF HENS RECEIVING DIETS CONTAINING UP TO 3 PPM OF METHANEARSONIC ACID.

Related reactions

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Nikkaji
J3.259J
Stability/Shelf LifeSTABLE
Dissociation ConstantspKa1= 4.1; pKa2= 9.02
Other Experimental Properties · 2 items

Strong dibasic acid.

Water high in calcium, magnesium and iron may cause precipitation; these cations form insoluble methane arsonate salts.

Physicochemical properties

Melting point
161 ° · 161°
Boiling point
393.3 · 393.3±25.0 °C(Predicted)
form
solid
pka
1 · pK1:3.41;pK2:8.18 (18°C)
Water Solubility
218.8 g/L · 218.8g/L(25 ºC)
Major Application
food and beverages
REACH Annex XVII Substances List
Methylarsonic acid (124-58-3)
EWG's Food Scores
1 · 1
FDA UNII
37 VJ5709S · J37VJ5709S
IARC
2 B · 2B (Vol. 100C) 2012
EPA Substance Registry System
Methylarsonic acid (124-58-3)
NACRES
24 · NA.24
Symbol(GHS)
9 · GHS09,GHS06
Signal word
Danger
Hazard statements
331 · H331-H301-H410
Precautionary statements
261 · P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501
RIDADR
2759 · 2759
HazardClass
6.1 · 6.1(b)
PackingGroup
III
Hazardous Substances Data
124 · 124-58-3(Hazardous Substances Data)
Toxicity
50 · mouse,LD50,oral,1800mg/kg (1800mg/kg),Journal of Agricultural and Food Chemistry. Vol. 45, Pg. 449, 1997.
Special Reports · 1 item

REVIEW OF THE CHEMICAL, PHYSICAL, & BIOL PROPERTIES & METHODS OF ANALYSIS FOR MONOMETHYLARSONIC ACID, CACODYLIC ACID, & THEIR SODIUM SALTS.[DIETZ EA JR, MOORE LO; MONOMETHYLARSONIC ACID, CACODYLIC ACID, AND THEIR SODIUM SALTS; ANAL METHODS PESTIC PLANT GROWTH REGUL 10: 385-401 (1978)]

FIFRA Requirements · 2 items

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

OSHA StandardsPermissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/
Atmospheric Standards · 4 items

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Methanearsonic acid is included on this list.

(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

Chemical DangersDecomposes on heating. This produces toxic fumes of arsenic oxides (see ICSC 0378). The solution in water is a medium strong acid.
Packaging and LabellingDo not transport with food and feedstuffs. Marine pollutant.
EPA Hazardous Waste Number · 1 item

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

Safety & protection

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures · 4 items

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

Safe StorageSeparated from strong bases and food and feedstuffs. Dry. Store in an area without drain or sewer access.
Storage ConditionsSOLID FORMULATIONS ARE SOMEWHAT HYGROSCOPIC & SHOULD BE STORED IN DRY PLACE.
Disposal Methods · 1 item

At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Spillage Disposal · 1 item

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Eye PreventionWear safety goggles or eye protection in combination with breathing protection if powder.
Inhalation RiskA harmful concentration of airborne particles can be reached quickly when dispersed.
Skin PreventionProtective gloves.
Minimum Risk LevelAcute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Exposure PreventionPREVENT DISPERSION OF DUST! AVOID ALL CONTACT!
Allowable Tolerances · 1 item

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/

Toxicology

Treatment · 1 item

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Health EffectsArsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
Environmental Fate · 3 items

EVOLUTION OF DIMETHYLARSINE & TRIMETHYLARSINE FROM GRASSES TREATED WITH SODIUM ARSENITE, METHYLARSONIC ACID, DIMETHYLARSINIC ACID, OR PHENYLARSONIC ACID CONFIRMED THE IDEA OF NATURAL BIOMETHYLATION.

Strongly adsorbed to soil; fixed by Fe and Al hydrous oxides in soil. Sorption increases as size of clay fraction decreases.

DECR IN PHYTOTOXICITY IS A RESULT OF FIXATION...MAINLY BY IRON & ALUMINUM HYDROUS OXIDES IN THE SOIL.

Food Survey Values · 1 item

NINETEEN SAMPLES REPRESENTING 13 VARIETIES OF RED & WHITE DOMESTIC TABLE WINES WERE ANALYZED FOR ARSENITE, ARSENATE, METHYLARSONIC ACID & DIMETHYLARSINIC ACID. THE CONCN OF ARSENITE RANGED FROM LESS THAN 1 TO 420 PPB, & THE CONCN OF ARSENATE RANGED FROM 1 TO 110 PPB. METHYLARSONIC ACID WAS BELOW LIMIT OF DETECTION OF 1 PPB.

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Exposure Routes · 2 items

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Oral (L2) ; inhalation (L2); dermal (L2)

Toxicity Summary · 1 item

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and Symptoms · 5 items

Cough. Sore throat.

Redness.

Redness.

Abdominal pain. Diarrhoea. Vomiting.

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

ICSC Environmental DataThe substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.
TSCA Test Submissions · 1 item

Methylarsenic acid was evaluated for clastogenicity in groups of 20 male Long-Evans rats injected intraperitoneally with total dose levels of 0 or 500 mg/kg bw, in three equal increments at 2 day intervals. Blood and bone marrow samples were obtained from each rat at 1 and 30 days after treatment, for determination of chromosomal abnormalities. The treatment increased the frequency of 1 type of chromosomal aberration (gap/break) in bone marrow cells obtained on day 1, indicating that the test compound was positive for clastogenicity in rats under the conditions of this assay. Positive control treatment with a single intraperitoneal injection of 0.3 mg/kg triethylenemelamine produced a significant increase in the frequency of chromosomal aberrations in bone marrow cells collected on day 1; bone marrow cells collected from positive control rats on day 30 and blood cells collected on day 1 or 30 were similar to negative controls in frequency of chromosomal aberrations.

Human Toxicity Excerpts · 1 item

SKIN IRRITATION OF THESE VARIOUS ARSENICALS VARY FROM VERY-MILD TO NONE, DEPENDING ON ACIDITY OR ALKALINITY OF EACH PREPN, & SKIN SENSITIVITY OF EXPOSED INDIVIDUAL. SYMPTOMS OF...SUBACUTE POISONING WITH ARSENICALS.../INCL METHANEARSONIC ACID/ SALTY TASTE, BURNING IN THROAT, & COLICKY PAINS IN STOMACH & INTESTINES. GARLICKY ODOR OF BREATH & SKIN IS FREQUENTLY PRESENT. SYMPTOMS OF ACUTE POISONING...HEADACHE, VOMITING, DIARRHEA, DIZZINESS, STUPOR, CONVULSIONS, GENERAL PARALYSIS, & DEATH.

Environmental Biodegradation · 1 item

THE METABOLISM OF MAA TO INORGANIC ARSENIC IS THE MAIN MECHANISM OF HERBICIDE DEGRADATION... THE ASSOC OF HERBICIDAL BREAKDOWN WITH THE GENERAL MICROBIOLOGICAL ACTIVITY SUGGESTS THAT THE OXIDATION OF MAA /METHANEARSONIC ACID/ OCCURRED COINCIDENTALLY WITH THE METAB OF SOIL ORG MATTER. ON THE OTHER HAND, BOTH NORFOLK LOAMY SAND SAMPLES (WITH & WITHOUT ORGANIC MATTER ADDED) SHOWED AN INCREASED DSMA /DISODIUM SALT OF MAA/ DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTED AN ADAPTATION OF THE MICROBIAL POPULATION TO METABOLIZE THE METHYL CARBON OF MAA. /INVESTIGATORS/...EXAM THE DEGRADATION OF MSMA /MONOSODIUM SALT OF MAA/ ON 4 SOILS. THEY CONCLUDED THAT SOIL MICROORGANISMS APPEARED TO PLAY SOME ROLE IN THE DECOMPOSITION PROCESS. A FUNGUS, SEVERAL ACTINOMYCETES, & SEVERAL BACTERIA WERE ISOLATED USING SOIL ENRICHMENT TECHNIQUES. THE ORGANISMS DEGRADED 3, 13 OR 9, & 20% OF THE MSMA IN 11 DAYS, RESPECTIVELY. HOWEVER, IN THE ABSENCE OF AN ENERGY SOURCE, MICROBIAL METABOLISM OF THE ORGANIC ARSENICAL WAS NONEXISTENT. THE PRODUCTS OF METABOLISM WERE CARBON DIOXIDE & ARSENATE. NO ARSENITE COULD BE DETECTED.

Regulatory information

FIFRA Requirements · 2 items

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Atmospheric Standards · 4 items

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Methanearsonic acid is included on this list.

(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

Clean Water Act Requirements · 3 items

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/

For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/

D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

State Drinking Water Guidelines · 2 items

(AZ) ARIZONA 10 ug/L /Arsenic/

(CT) CONNECTICUT 10 ug/l /Arsenic/

Federal Drinking Water Standards10 ug/l /Arsenic/

Safety data

ridadr
2759
Toxicity
mouse,LD50,oral,1800mg/kg (1800mg/kg),Journal of Agricultural and Food Chemistry. Vol. 45, Pg. 449, 1997.
Signal word
Danger
Symbol(GHS)
GHS09,GHS06
hazard_class
6.1(b)
packing_group
III
Hazard statements
H331-H301-H410
Precautionary statements
P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501
Hazardous Substances Data
124-58-3(Hazardous Substances Data)

/COTTON/ COTYLEDONS ABSORBED MAA /METHANEARSONIC ACID/ & MSMA /MONOSODIUM METHANEARSONIC ACID/ MORE READILY THAN DSMA. ... ABSORPTION OF (14)C DSMA TENDED TO INCREASE WITH TEMPERATURE. /METHANEARSONIC ACID, DISODIUM SALT/

Uses & manufacturing

Uses · 5 items

Used as herbicide in the past; [Merck Index] Not currently registered with the EPA for use in the US; [HSDB]

Farming (Pesticides) [Category: Industry]

For Methanearsonic acid (USEPA/OPP Pesticide Code: 128876) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Herbicide /Former use/

Methylarsonic acid, disodium salt is used as an herbicide and pesticide. (L389)

Methods of Manufacturing · 1 item

Prepared from sodium arsenite and methyl iodide: Quick, Adams, J Am Chem Soc 44, 809 (1922). The disodium salt is...prepared by treating sodium arsenite with dimethyl sulfate at 85 °C... other routes are by reaction of methyl chloride with sodium arsonate under pressure: Miller et al, US patent 2,442,372 (1948); by the reaction of dimethyl sulfate with soln of arsenic trioxide in sodium hydroxide: Schwerdle, US patent 2,889,347 (1959).

General Manufacturing InformationPatent assingments: US Patents: 2,678,265; 3,030,199; 3,035,910; 3,056,670; 3,056,821; 3,068,088.

Applications

DescriptionSalts of methanearsonic acid,CH3AsO(OH)2, especially the iron ammonium salt, Neoasozin, used as a fungicide in rice growing and the sodium, ammonium, and diethanolam monium salts used as herbicides in cotton growing.

UsesMethylarsonic acid is used as herbicide.

Upstream & downstream products

Downstream products

Arsenic diiodo methanemethanearsonous acid

Suppliers11 total

陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
山东小野化学股份有限公司0539-6362799 20）
Shaanxi Dideu New Materials Co. Ltd18192503167 · [email protected]
Shaanxi Didu New Materials Co. Ltd+86-86-17392712779 +86-13289823923 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
厦门盈融达化工有限公司+86-0592-6210733 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]

Additional notes

DefinitionChEBI: Methylarsonic acid is a member of arsonic acids, a one-carbon compound and an organoarsonic acid. It is a conjugate acid of a methylarsonate(1-).