Basic information
- CAS
144-33-2- Standard SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)O.[Na+].[Na+]- InChIKey
CEYULKASIQJZGP-UHFFFAOYSA-L- Molecular formula
- C6H6Na2O7
- Average molar mass
- 236.09 g/mol
- Monoisotopic mass
- 235.99089109
Names & identifiers
- Preferred name
- Disodium Hydrogen Citrate
- IUPAC
- disodium;3-carboxy-3-hydroxypentanedioate
- English name
- Disodium citrate
- Molecular formula
- C6H6Na2O7
- Molecular weight
- 236.09
Names & synonyms
Disodium citrate144-33-2AlkacitronCitralkaSodium acid citrateSodium citrate, acidNatrium citricumNatrium citricum [German]Citric acid, disodium saltDISODIUM HYDROGEN CITRATEDisodium monohydrogen citrateHSDB 375
Show more names
Sodium 2-(carboxymethyl)-2-hydroxysuccinatenatriumcitricumSODIUMACIDCITRATEsodiumcitrate,acidDisodiuM Citrate Disodium Chromtropate2-Hydroxy-disodiumsalt
Citric acid disodium saltUNII-6FO62KCQ7AEINECS 205-623-3Disodium 2-hydroxy-1,2,3-propanetricarboxylate6FO62KCQ7ADTXSID50889423NATRIUM CITRICUM (GERMAN)SODIUM CITRATE ACID
Database identifiers
- CAS
144-33-2- PubChem CID
- 8950
- DTXSID
DTXSID50889423- EC Number
- 205-623-3
- Nikkaji
- J2.344.233G
Properties
Computed structural properties
- Topological polar surface area
- 138 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 216
Experimental & physicochemical properties
Chemical ClassesMetals -> Organic Acids, Metal Salts
pHBetween 4,9 and 5,2 (1 % aqueous solution)
Food AdditivesSTABILIZER OR THICKENER -> FDA Substance added to food
Physical Description
Crystalline white powder or colourless crystals
White solid; [Merck Index] White powder or fine crystals; Odorless; [Merck Eurolab MSDS]
Other Experimental PropertiesWHITE POWDER; SALINE TASTE; PH OF 3% WT/VOL SOLN IN WATER: 4.9-5.2; 1 G DISSOLVES IN LESS THAN 2 ML WATER /SESQUIHYDRATE/
Physicochemical properties
- Melting point
- 240 °C · 240°C
- Density
- 1.858 · 1.858[at 20℃]
- vapor pressure
- 0 Pa · 0Pa at 20℃
- storage temp.
- Store at room temperature, keep dry and cool
- solubility
- Freely soluble in water; practically insoluble in ethanol (96%).
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (116 of 116) of all reports.
Not Classified
Aggregated GHS information provided per 116 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, disodium salt
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Disodium hydrogen citrate (EC: 205-623-3)
Disodium citrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, disodium salt: Human health tier I assessment
Hazards SummaryCauses convulsions and cyanosis in intravenous and intraperitoneal lethal-dose studies of mice and rats; [RTECS] An eye and respiratory tract irritant; [Merck Eurolab MSDS] See Citric acid.
Hazard Classes and CategoriesNot Classified
Safety data
- tsca
- TSCA listed
- rtecs
- GE7580000
- Toxicity
- LD50 in mice, rats (mmol/kg): 7.5, 7.3 i.p. (Gruber, Halbeisen)
Chemistry & industry
Uses & manufacturing
Uses
Used almost exclusively as an anticoagulant for blood transfusions; [HSDB] Used as a stabilizer or thickener for foods; [FDA] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
ANTICOAGULANT, FOR USE IN TRANSFUSIONS
U.S. Exports
(1972) No Data
(1975) No Data
U.S. Imports
(1972) No Data
(1975) No Data
U.S. Production
2023: <75,000 lb
(1972) No Data
(1975) No Data
Consumption PatternsESSENTIALLY 100% AS AN ANTICOAGULANT (1976)
Industry UsesIntermediate
Methods of ManufacturingPROBABLY REACTION OF CITRIC ACID WITH SODIUM HYDROXIDE
Household ProductsInformation on 2 consumer products that contain Disodium hydrogen citrate in the following categories is provided:
Use ClassificationFood additives
General Manufacturing Information
Textiles, apparel, and leather manufacturing
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2): ACTIVE
ANTICOAGULANT...IN SOLN WITH GLUCOSE TO PREVENT CLOTTING OF BLOOD INTENDED FOR TRANSFUSION. PREFERABLE TO SODIUM CITRATE, SINCE IT PREVENTS CARAMELIZATION OF GLUCOSE ON STERILIZATION BECAUSE OF ITS ACIDITY. SUITABLE SOLN CONTAINS 1.7 TO 2% & 2.5% DEXTROSE; 120 ML OF THIS SOLN PREVENTS CLOTTING OF 420 ML BLOOD.
Related reactions
1 records
Compound notes
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