Basic information
- CAS
149-17-7- Standard SMILES
COc1cc(C=NNC(=O)c2ccncc2)ccc1O- InChIKey
PSWOBQSIXLVPDV-UHFFFAOYSA-N- Molecular formula
- C14H13N3O3
- Average molar mass
- 271.27 g/mol
- Monoisotopic mass
- 271.09569129
Overview
Ftivazide is a derivative of isoniazid, used to treat tuberculosis in the Soviet Union.
Names & identifiers
- Preferred name
- Isonicotinic acid vanillylidenehydrazide
- IUPAC
- N-[(4-hydroxy-3-methoxyphenyl)methylideneamino]pyridine-4-carboxamide
- English name
- Ftivazide
- Molecular formula
- C14H13N3O3
- Molecular weight
- 271.27
Names & synonyms
PhthivazidFtivazide [INN]Isonicotinic acid vanillylidenehydrazide149-17-740Q4C3O4V0PhthivazidePhtivazideVanillaberonFtivazidFtivazidaPhtivazidVancide
Show more names
FtivazideFtivazide USP/EP/BPCompound T86473(SC)isonicotinic acid, vanillylidenehydrazide
VanicidVanizideN'-[(4-HYDROXY-3-METHOXYPHENYL)METHYLIDENE]PYRIDINE-4-CARBOHYDRAZIDEFtivazidumPhthivazidumNSC 31725NSC-31725Ftivazidum [INN-Latin]
Database identifiers
- CAS
149-17-7- PubChem CID
- 8996
- DTXSID
DTXSID3020758- UNII
- 40Q4C3O4V0
Properties
Computed structural properties
- XLogP
- 1.6
- Topological polar surface area
- 83.8 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 343
Physicochemical properties
- Melting point
- 219 · 219-220 °C
- Boiling point
- 414.36 °C · 414.36°C (rough estimate)
- Density
- 1.2122 · 1.2122 (rough estimate)
- refractive index
- 1.57 · 1.5700 (estimate)
- pka
- 8.65 · 8.65±0.35(Predicted)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 40 Q4C3O4V0 · 40Q4C3O4V0
Chemistry & industry
Applications
UsesIsonicotinic Acid Vanillylidenehydrazide exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and anti-microbial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger.Also, it is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
Upstream & downstream products
Upstream raw materials
Suppliers9 total
艾吉析科技（上海）有限公司17717235263 · [email protected]
吉林中科研伸科技有限公司18143011203 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
上海麦克林生化科技股份有限公司50706066 15221275939 · [email protected]
Jilin Chinese Academy of Sciences-yanshen Technology18143011203 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…