Edetate Trisodium

Ethylenediamine tetraacetic acid, trisodium salt is an odorless white crystalline powder. pH (1% aqueous solution) 9.3. pH (10% aqueous solution) about 8.3-8.7. (NTP, 1992)

Dry Powder; Liquid

White odorless solid; [CAMEO] Fine white crystals; [Sigma-Aldrich MSDS]

This chemical does not meet GHS hazard criteria for 1% (2 of 197) of reports.

Danger

H302+H332 (53.3%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]；H302 (87.8%): Harmful if swallowed [Warning Acute toxicity, oral]；H318 (66%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H319 (25.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H332 (62.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H373 (66%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 197 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 2 of 197 reports by companies.；There are 12 notifications provided by 195 of 197 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3)

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 20-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/27615

Trisodium EDTA: Does not have an individual approval but may be used under an appropriate group standard

SYMPTOMS: Symptoms of exposure to this compound may include coughing, wheezing, respiratory distress and mucous membrane irritation upon inhalation. It is a strong chelating agent and ingestion of large amounts may cause hypocalcemic tetany with spontaneous recovery. This compound may cause skin irritation, an eye contact may cause pain and slight transient irritation.；ACUTE/CHRONIC HAZARDS: When heated to decomposition this chemical may emit toxic fumes of carbon monoxide, carbon dioxide, oxides of nitrogen and ammonia. It may also emit very toxic fumes of disodium oxide. This compound may present a dust explosion hazard. (NTP, 1992)

No evidence of carcinogenicity in mice or rats; [NTP] Causes changes in tubules (including acute renal failure and necrosis) in intraperitoneal lethal-dose studies of mice; [RTECS] May cause skin and eye irritation; Inhalation may cause coughing, wheezing, respiratory distress, and mucous membrane irritation; [NTP] An irritant; [Sigma-Aldrich MSDS] See Edetic acid.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and keep it away from all oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Trisodium ethylenediaminetetra-acetate trihydrate (EDTA)

TR-011: Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) for Possible Carcinogenicity (CASRN 150-38-9) (1977 )

07/25/77

No Evidence

No Evidence

No Evidence

Chemical: Glycine, N,N′-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3)

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 20-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/27615

Trisodium EDTA: Does not have an individual approval but may be used under an appropriate group standard

CIR ingredient: Trisodium EDTA

Formerly registered in the US for use as a disinfectant; [NPIRS] Used as a preservative, color retention agent, antioxidant, flavoring agent for foods, anticoagulant for blood collection, and chelating agent in personal care products; Also used in the pulp and paper industry, in laboratory titrimetric analysis of metals, and as a therapeutic chelating agent; [Merck Index] Used in detergents, agricultural chemical sprays, pharmaceutical products, oil emulsions, to improve dyeing in textiles, as a metal chelating agent, in metal cleaning and plating, to decontaminate radioactive surfaces, as a metal deactivator in vegetable oils, as an eluting agent in ion exchange, to remove insoluble deposits of calcium and magnesium soaps, as an antioxidant, in the clarification of liquids, and to help reduce blood cholesterol; [NTP] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Acid and Alkali Cleaning of Metals [Category: Clean]；Electroplating [Category: Plate]；Pulp and Paper Processing [Category: Industry]；Using Disinfectants or Biocides [Category: Clean]；Textiles (Printing, Dyeing, or Finishing) [Category: Industry]

All Other Basic Organic Chemical Manufacturing；Soap, Cleaning Compound, and Toilet Preparation Manufacturing

Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:3): ACTIVE