Basic information
- Standard SMILES
COCCOCCOCCOCCO- InChIKey
ZNYRFEPBTVGZDN-UHFFFAOYSA-N- Molecular formula
- C9H20O5
- Average molar mass
- 208.25 g/mol
- Monoisotopic mass
- 208.13107374
Overview
5S,6S-epoxy-15R-hydroxy-ETE is a poly(ethylene glycol).
Names & identifiers
- Preferred name
- Tetraethylene glycol monomethyl ether
- IUPAC
- 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol
- English name
- Tetraethyleneglycol monomethyl ether
- Molecular formula
- C9H20O5
- Molecular weight
- 208.25
Names & synonyms
23783-42-82,5,8,11-Tetraoxatridecan-13-olTetraethylene glycol monomethyl etherDTXSID3027829DTXCID507829RefChem:1099661Tetraethyleneglycol monomethyl etherm-PEG4-alcoholmPEG4-OH3,6,9,12-Tetraoxatridecan-1-ol2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanolMethyl Tetraglycol
Show more names
MTeGHO-(CH2CH2O)4-MeMethyl-PEG4-alcohol
C9H20O5MFCD000417565S,6S-epoxy-15R-hydroxy-ETE3,6,9,12-tetraoxatridecanol3,6,9,12-TetraoxotridecanolPEG-4 methyl ether2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOLTetraethyleneglycol monomethylether
Database identifiers
- CAS
23783-42-8- PubChem CID
- 90263
- DTXSID
DTXSID3027829- ChEMBL
CHEMBL1232586- ChEBI
CHEBI:189796- UNII
- 9V7ZMW7RF5
- EC Number
- 245-883-5
- Nikkaji
- J97.011E
Properties
Computed structural properties
- XLogP
- -1
- Topological polar surface area
- 57.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 11
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 99.2
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
SolventsSolvents -> Glycol Ethers (E Series)
CosmeticsCosmetic ingredients (PEG-4 Methyl Ether) -> CIR (Cosmetic Ingredient Review)
SpringerMaterials PropertiesSurface tension
SurfactantsSurfactant
LogP-0.6
Density
1.06 g/cm³
Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00
Viscosity11.5-12.5 mm²/s at 20 °C
SolubilitySolubility in water: miscible
Flash Point161 °C c.c.
Boiling Point280-350 °C
Melting Point-39 °C
Physicochemical properties
- Boiling point
- 158 · 158-160 °C (5 mmHg)
- Density
- 1.045 g/mL · 1.045 g/mL at 25 °C
- vapor pressure
- 0.1 Pa · 0.1Pa at 20℃
- refractive index
- 1.444 · 1.444-1.446
- Flash point
- 110 °C · >110°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- form
- Liquid
- pka
- 14.36 · 14.36±0.10(Predicted)
- color
- Clear colorless to very slightly yellow
- Water Solubility
- 999 · Water solubility 999,999c.
- α-end
- methoxy
- Ω-end
- hydroxyl
- InChI
- 1S/C9H20O5/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h10H,2-9H2,1H3
- InChIKey
- ZNYRFEPBTVGZDN-UHFFFAOYSA-N
- SMILES
- COCCOCCOCCOCCO
- LogP
- -1.5 at · -1.5 at 20℃
- CAS DataBase Reference
- 23783 · 23783-42-8(CAS DataBase Reference)
- FDA UNII
- 3 S6PWQ487V · 3S6PWQ487V
- EPA Substance Registry System
- 2 · 2,5,8,11-Tetraoxatridecan-13-ol (23783-42-8)
- UNSPSC Code
- 12162002 · 12162002
- NACRES
- 23 · NA.23
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319
- Precautionary statements
- 264 · P264-P280i-P305+P351+P338-P337+P313
- PPE
- Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
- Safety Statements
- 24 · 24/25-22
- WGK Germany
- 1 · 1
- TSCA
- TSCA listed
- HS Code
- 29094990 · 29094990
- Storage Class
- 10 · 10 - Combustible liquids
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 96.9% (155 of 160) of all reports.
Not Classified
Aggregated GHS information provided per 160 reports by companies from 3 notifications to the ECHA C&L Inventory.
Not Classified
Hazard information
Regulatory Information
Chemical: 2,5,8,11-Tetraoxatridecan-13-ol
3,6,9,12-Tetraoxatridecan-1-ol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 3,6,9,12-Tetraoxatridecan-1-ol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: 3,6,9,12-tetraoxotridecanol (EC: 245-883-5)
2,5,8,11-Tetraoxatridecan-13-ol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Fire HazardsCombustible.
Hazards Summary
Not a skin or eye irritant in rabbits; [IUCLID] Similar glycol ethers demonstrate low acute toxicity by oral, dermal, and inhalation exposure; Histopathological liver changes and testicular toxicity at high doses in sub-chronic oral studies of rats; [OECD SIDS: High Boiling Ethylene Glycol Ethers - 2002] May cause irritation; [Acros Organics MSDS] See Tetraethylene glycol butyl ether.
Chemical DangersReacts with strong oxidants.
Hazard Classes and CategoriesNot Classified
Safety & protection
Fire FightingUse water spray, dry powder, alcohol-resistant foam, carbon dioxide.
First Aid Measures
Fresh air, rest.
Rinse skin with plenty of water or shower.
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Do NOT induce vomiting.
Safe StorageSeparated from strong oxidants.
Spillage DisposalPersonal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away spilled liquid with plenty of water.
Eye PreventionWear safety goggles.
Fire PreventionNO open flames.
Inhalation RiskA harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.
Skin PreventionProtective gloves.
Ingestion PreventionDo not eat, drink, or smoke during work.
Inhalation PreventionUse ventilation.
Effects of Short Term ExposureThe substance is mildly irritating to the eyes. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Toxicology
Adverse EffectsNeurotoxin - Acute solvent syndrome
Toxicity Summary
The CIR Expert Panel concluded that the alkyl PEG ethers, listed below, are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonirritating. This assessment is also intended to address future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units...PEG-4 Methyl Ether...
Safe for use in cosmetics, with qualifications
Signs and Symptoms
Redness.
Redness.
Safety data
- PPE
- Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
- wgk
- 1
- tsca
- TSCA listed
- hs_code
- 29094990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 24/25-22
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H319
- REACH Registrations
- Active
- Precautionary statements
- P264-P280i-P305+P351+P338-P337+P313
Chemistry & industry
Uses & manufacturing
Uses
CIR ingredient: PEG-4 Methyl Ether
Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Used in the automobile industry in brake and hydraulic fluids; [IUCLID] Only available commercially in glycol ether mixtures; High boiling ethylene glycol ethers are mainly used in automotive hydraulic brake fluids; [OECD SIDS: High Boiling Ethylene Glycol Ethers - 2002]
U.S. Production2023: 5,000,000 - <10,000,000 lb
Consumer UsesHydraulic fluids
Industry UsesEmulsifier
Household ProductsInformation on 2 consumer products that contain Tetraethylene Glycol Monomethyl Ether in the following categories is provided:
General Manufacturing Information
Plastics Product Manufacturing
3,6,9,12-Tetraoxatridecan-1-ol: ACTIVE
Applications
Descriptionm-PEG4-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses2,5,8,11-Tetraoxatridecan-13-o1, can be used in the synthesis of various chemicla compounds. It is also a monofunctional PEG that can be used in polymer science.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers50 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
广州纳珑化工有限公司13192879270; 13192879270 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]
Syntechem Co.,Ltd[email protected]
Ark Pharm, Inc.847-367-3680 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
上海景颜化工科技有限公司13817811078 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
ChemPep, Inc.+1 (888) 615-9178 / (561) 791-8787 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
南京诺利斯医药科技有限公司13901585132 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
上海睿升化工科技有限公司+86-021-50935922
河南赢创生物科技有限公司15672878902 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
郑州阿尔法化工有限公司0371-53732842 15981811963 · [email protected]
Labnetwork lnc.+86-27-50766799 +86-18062016861 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
湖南华腾制药有限公司400-8592883 · [email protected]
上海鑫圭生物科技有限公司15121041756 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海嵩爰化工科技有限公司010-1234567 18521000990 · [email protected]
上海有朋化工有限公司021-69005955 13701776567 · [email protected]
北京海力扬化学科技有限公司13718199399 · [email protected]
四川海诺威科技有限公司13708085536 13708085536 · [email protected]
上海凯赛化工有限公司021-33516722 13701817765 · [email protected]
上海彤源化工有限公司021-021-69182866 13701855675 · [email protected]
上海蓝润化学有限公司021-69515658 ; 69515628 13701998368 · [email protected]
上海容立化学科技有限公司021-69992220 13701886816 · [email protected]
上海康拓化工有限公司021-69185552 13701777608 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
AN PharmaTech Co Ltd86(21)68097365 · [email protected]
铜陵恒优生物科技有限公司021-50426030 13856289449;13124863828 · [email protected]
Additional notes
DefinitionChEBI: 5S,6S-epoxy-15R-hydroxy-ETE is a poly(ethylene glycol).
Related reactions
19 records
Linked notes
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