Basic information
- CAS
22304-30-9- Standard SMILES
CCCC1C(=O)N2C(N(C)C)=Nc3ccc(C)cc3N2C1=O.O.O- InChIKey
LLMGYOJUHDRDFJ-UHFFFAOYSA-N- Molecular formula
- C16H24N4O4
- Average molar mass
- 336.39 g/mol
- Monoisotopic mass
- 336.17975526
Names & identifiers
- Preferred name
- Apazone Dihydrate
- IUPAC
- 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione;dihydrate
- English name
- Azapropazone
- Molecular formula
- C16H24N4O4
- Molecular weight
- 336.38616
Names & synonyms
Apazone dihydrateAzapropazone dihydrate22304-30-9BF18764H96DTXSID6022634RefChem:113295DTXCID902634Tolyprin1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, dihydrateProlixana5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione;dihydrate1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione,5-(dimethylamino)-9-methyl-2-propyl-, hydrate (1:2)
Show more names
Prolixan
Azapropazon dihydratAzapropazon dihydrat [German]UNII-BF18764H961,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrateAPAZONE DIHYDRATE [MI]orb1703725SCHEMBL1723119
Database identifiers
- CAS
22304-30-9- PubChem CID
- 90763
- DTXSID
DTXSID6022634- UNII
- BF18764H96
Properties
Computed structural properties
- Topological polar surface area
- 58.2 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 516
Physicochemical properties
- Melting point
- 247 · 247-248°
- FDA UNII
- 18764 H96 · BF18764H96
- Toxicity
- 50 orl-rat: · LD50 orl-rat: 1950 mg/kg ARZNAD 23,1215,73
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 orl-rat: 1950 mg/kg ARZNAD 23,1215,73
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
Applications
UsesAzapropazone-d7 Dihydrate is labelled Azapropazone (A802400) which is a non-steroidal anti-inflammatory drug.
Suppliers6 total
Alfa Chemistry1-516-6625404 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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