CAS 28443-50-7 2-Amino-5-chlorophenol (HCID 91591)

Names & identifiers

Preferred name: 2-Amino-5-chlorophenol
IUPAC: 2-amino-5-chlorophenol
English name: 2-Amino-5-chlorophenol
Molecular formula: C6H6ClNO
Molecular weight: 143.57

Names & synonyms

2-Amino-5-chlorophenol28443-50-74-chloro-2-hydroxyanilinePhenol, 2-amino-5-chloro-5-chloro-2-aminophenol6VK2H53LQNDTXSID6067385CHEBI:75051RefChem:85263DTXCID0037819249-020-3MFCD02093863

Show more names

TIMTEC-BB SBB0041372-Amino-5-chlorophenCyclohexane Impurity 1Lenvatinib Impurity 82Chlorzoxazone Impurity 242-Amino-5-chlorophenol 97%2-Amino-5-chlorophenol,99%

2-amino-5-chloro-phenolEINECS 249-020-35-chloro-o-aminophenol2-hydroxy-4-chloroanilineUNII-6VK2H53LQNEC 249-020-3SCHEMBL1033293-CHLORO-6-AMINOPHENOL

Database identifiers

CAS: 28443-50-7
PubChem CID: 91591
DTXSID: DTXSID6067385
ChEBI: CHEBI:75051
UNII: 6VK2H53LQN
EC Number: 249-020-3
Nikkaji: J88.559B

Properties

Computed structural properties

XLogP: 1.8
Topological polar surface area: 46.3 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 9
Formal charge: 0
Complexity: 99

Physicochemical properties

Melting point: 145 · 145-153 °C (lit.)
Boiling point: 185.5 °C · 185.5°C (rough estimate)
Density: 1.2028 · 1.2028 (rough estimate)
vapor pressure: 0.002 · 0.002-0.094Pa at 20-50℃
refractive index: 1.5618 · 1.5618 (estimate)
storage temp.: -20 °C, · -20°C, stored under nitrogen
solubility: soluble in Methanol
pka: 8.79 · 8.79±0.10(Predicted)
form: Powder
color: Light brown
InChI: InChI=1S/C6H6ClNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2
InChIKey: FZCQMIRJCGWWCL-UHFFFAOYSA-N
SMILES: C1(O)=CC(Cl)=CC=C1N
CAS DataBase Reference: 28443 · 28443-50-7(CAS DataBase Reference)
FDA UNII: 6 VK2H53LQN · 6VK2H53LQN
EPA Substance Registry System: 2 · Phenol, 2-amino-5-chloro- (28443-50-7)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi,Xn
Risk Statements: 36 · 36/37/38-20/21/22
Safety Statements: 26 · 26-36-36/37/39
WGK Germany: 3 · 3
Hazard Note: Irritant
TSCA: TSCA listed
HazardClass: 6.1 · 6.1
HS Code: 29222990 · 29222990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
REACH Registrations: Inactive

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H315 (97.7%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (97.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (95.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationStatus: Cease Manufacture Update: 19-02-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12346

Hazard Classes and CategoriesSkin Irrit. 2 (97.7%)；Eye Irrit. 2 (97.7%)；STOT SE 3 (95.3%)

Regulatory information

Regulatory InformationStatus: Cease Manufacture Update: 19-02-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12346

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
hs_code: 29222990
risk_code: 36/37/38-20/21/22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi,Xn
hazard_note: Irritant
safety_code: 26-36-36/37/39
hazard_class: 6.1
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
REACH Registrations: Inactive
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPhenol, 2-amino-5-chloro-: ACTIVE

Applications · 2 items

Uses2-Amino-5-chlorophenol may be used to synthesize 2-amino-5-chloromuconic semialdehyde and benzoxazole derivatives.

General Description2-Amino-5-chlorophenol can be synthesized from 2-chloro-5-nitrophenol via reduction. It can also be obtained from 1-chloro-4-nitrobenzene by using a bacterial strain LW1. 2-Amino-5-chlorophenol participates in the condensation reaction with acetylferrocene to afford ferrocenyl Schiff bases bearing a phenol group.

Upstream & downstream products

Downstream products

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

上海达立康医药科技有限公司18658316824

温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]

环生美森医药技术（山东）有限公司0531-88762217 18301471076 · [email protected]

Additional notes

DefinitionChEBI: Phenol carrying amino and chloro substituents at positions 2 and 5 respectively. It is part of the degradation pathway of 4-chloronitrobenzene, CHEBI:34399.