Lysipressin acetate
Basic information
- CAS
83968-49-4- Standard SMILES
CC(=O)O.NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O- InChIKey
NKWAIKZITYLOMT-DHSVNZEYSA-N- Molecular formula
- C48H69N13O14S2
- Average molar mass
- 1,116.3 g/mol
- Monoisotopic mass
- 1,115.45283627
Names & identifiers
- Preferred name
- Lysipressin acetate
- IUPAC
- acetic acid;(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
- English name
- Vasopressin, 8-l-lysine-, monoacetate (salt)
- Molecular formula
- C48H69N13O14S2
- Molecular weight
- 1116.27016
Names & synonyms
83968-49-4Lysipressin acetateLysipressin (acetate)LysipressinacetateVasopressin, 8-l-lysine-, monoacetate (salt)EINECS 281-529-6acetic acid;(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamideLysipressin Acetic Acid SaltLypressin;Diapid;Lys Vasopressin;Lysine Vasopressin;
Show more names
Lys8]-Vasopressin acetate8-L-Lysine-vasopressin monoacetate(salt)Lysipressin Acetate :Lysipressin AcetateH-D-Cys(1)-D-Tyr-D-Phe-D-Gln-D-Asn-D-Cys(1)-D-Pro-Lys-Gly-NH2.CH3CO2H
[Lys8]-Vasopressin acetateorb1309456NKWAIKZITYLOMT-DHSVNZEYSA-Nnyl)pyrrolidine-2-carboxamide acetateAKOS030485978CS-0012393C76681F986705
Database identifiers
- CAS
83968-49-4- PubChem CID
- 91844584
- EC Number
- 281-529-6
Properties
Computed structural properties
- Topological polar surface area
- 513 Ų
- Hydrogen bond donors
- 14
- Hydrogen bond acceptors
- 18
- Rotatable bonds
- 19
- Heavy atoms
- 77
- Formal charge
- 0
- Complexity
- 1,990
Physicochemical properties
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- 10 mM · DMSO: 10 mM
- form
- A solid
- color
- White to off-white
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 332 · H332
- Precautionary statements
- 261 · P261-P271-P304+P340-P312
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H332
- Precautionary statements
- P261-P271-P304+P340-P312
Chemistry & industry
Applications
DescriptionLysipressin is a peptide hormone found in pigs and marsupials that corresponds to amino acids 20-28 of the vasoconstrictor peptide vasopressin with lysine in place of arginine at position 27.1,2 It is an arginine vasopressin receptor 1A (V1A) receptor agonist that binds to rat and human V1A receptors (Kis = 1.2 and 10.1 nM, respectively) and increases intracellular calcium levels in cultured rat and human aortic cells with half-maximal activation (Kact) values of 12 and 20.8 nM, respectively.3 Lysipressin induces vasoconstriction in isolated mesenteric arteries from normotensive and spontaneously hypertensive rats.4 It also has antidiuretic effects in non-anesthetized dwarf pigs, decreasing urine volume and increasing urinary solutes without affecting the glomerular filtration rate.1WARNING This product is not for human or veterinary use.
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