D-Ethionine

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

ACUTE TOXICITY IN MICE OF D-ETHIONINE WAS SUPPRESSED BY L-METHIONINE AND ADENINE.

DL-METHIONINE @ 0.6-0.8% IN DIET FED SIMULTANEOUSLY WITH ETHIONINE PREVENTS DEVELOPMENT OF LIVER TUMORS /IN RATS/.

IN RATS...LABELLING IN VIVO OF LIVER PROTEINS BY TRITIATED DIMETHYLNITROSAMINE WAS...LARGELY INHIBITED BY...ETHIONINE...

...TUMOR OF THE IRIS HAS BEEN OBSERVED IN RATS' EYES AFTER REPEATED SYSTEMIC ADMIN IN COMBINATION WITH N-2-FLUORENYLACETAMIDE.

DL-ETHIONINE INDUCED HEPATIC CARCINOMAS IN MALE RATS FED FOR 16-20 MONTHS AS 0.1% OF A 16% CASEIN, CHOLINE-SUPPLEMENTED DIET. 50% OF FEMALE MICE FED 0.1% OF DL-ETHIONINE IN THE SAME DIET DEVELOPED HEPATOMAS BY 18 MONTHS; MALE MICE WERE LESS SUSCEPTIBLE. /D,L-ETHIONINE/

Varying amounts of DL-, L-, D-ethionine were admin iv to sheep, either as a continuous infusion, usually over 2 days, or as a single injection. Groups of sucking mice and rats in their first cycle of hair growth, were given sc injections of DL-ethionine at several dose rates. Ethionine was a potent inhibitor of wool growth in sheep; the L- and D-isomers appeared equally effective. An infusion of 20 mg/kg DL-ethionine ... given at the daily rate of 10 mg/kg for 2 days, or an injection of 40 mg/kg DL-ethionine ... were sufficient to cause the growth of very weak wool and allow the fleece to be readily removed by hand within 3 wk after dosing. The inhibition of wool growth was usually associated with a concn of ethionine in blood plasma, during iv infusion, of 10 umol/l or higher. An infusion of DL-ethionine at a daily rate of 1 mg/kg for 12 days caused the growth of weak fibers and substantially reduced both length growth rate and diameter of fibers. The toxicity of ethionine to sheep was dependent on the total dose and the duration of administration. An infusion of 40 mg/kg (20 mg/kg/day for 2 days) produced severe effects, but the sheep recovered; a dose of 14 mg/kg (2 mg/kg for 7 days) was lethal. ... Doses of DL-ethionine as high as 460 mg/kg failed to cause hair loss is sucking mice. While body growth was severely retarded at this dose, no deaths occurred. ... DL-ethionine failed to cause hair loss in sucking rats, but was lethal to some rats at a dose of 360 mg/kg.

OPTIMAL INDUCTION OF /RAT/ LIVER TUMORS REQUIRES CONTINUOUS FEEDING OF SYNTHETIC DL-ETHIONINE (0.25% IN DIET) FOR...5 MO. ... THOUGH ETHIONINE CAUSES ACUTE DEGENERATIVE LESIONS IN PANCREATIC ACINI & PREVENTS ALLOXAN DIABETES, NO PANCREATIC TUMORS...REPORTED. /DL-FORM/

CHEM TERATOGENS THAT REQUIRE METAB OR BIOACTIVATION TO ELECTROPHILIC REACTANTS INCL...ETHIONINE... MOST FREQUENTLY IT IS LIVER THAT PRODUCES VARIETY OF ELECTROPHILIC REACTANTS THAT, LIKE ALKYLATING AGENTS, COVALENTLY BIND TO MACROMOLECULES.

For more Non-Human Toxicity Excerpts (Complete) data for (D)-ETHIONINE (8 total), please visit the HSDB record page.

RATS FED 0.25% DL-ETHIONINE FOR 3 DAYS SHOWED ELEVATED TRNA METHYLTRANSFERASE & INHIBITED GLYCINE METHYLTRANSFERASE LEVELS IN THE LIVER. THESE CHANGES PERSIST THROUGHOUT THE CARCINOGENIC REGIME & SIMILAR TRENDS WERE OBSERVED IN ETHIONINE-INDUCED LIVER TUMORS. D-ETHIONINE WAS EQUALLY EFFECTIVE IN ELEVATING TRNA METHYLTRANSFERASE IN THE LIVER, IN BOTH MALE & FEMALE RATS.

/ETHIONINE/ INHIBITS THE INCORPORATION OF METHIONINE AND GLYCINE INTO RAT PROTEIN IN VIVO AND THE CONVERSION OF METHIONINE INTO CYSTEINE. ETHIONINE IS DEETHYLATED, AND THE ETHYL GROUP APPEARS IN ANALOGUES OF METABOLITES KNOWN TO PARTICIPATE IN TRANSMETHYLATION REACTIONS, EG ETHYL CHOLINE. IN THE RAT IT IS ITSELF INCORPORATED INTO ABNORMAL PROTEINS COMPETITIVELY, BUT ITS AFFINITY IS ONLY 1/600 THAT OF METHIONINE.

THE QUANTITATIVE STUDY OF THE INVERSION OF D-ETHIONINE INTO L-ETHIONINE IN VIVO, MEASURED IN THE LIVER OF RATS BY THE FORMATION OF S-ADENOSYLETHIONINE FROM L-ETHIONINE, DEMONSTRATES HIGH EFFICIENCY OF THIS CONVERSION WHEN LOWER DOSES OF D-ETHIONINE ARE USED. AT HIGHER DOSES (MORE THAN 25 MG (80 UMOL)/100 G BODY WT), ACCUMULATION OF S-ADENOSYLETHIONINE IS RETARDED. THIS DECR OF S-ADENOSYLETHIONINE FORMATION MAY BE DUE TO AN UNKNOWN EFFECT OF D-ETHIONINE ON THE L-ETHIONINE METABOLISM.

Used as a foliar spray to lower the incidence of potato common scab; [HSDB]

Farming (Pesticides) [Category: Industry]