Basic information
- CAS
1235-82-1- Standard SMILES
Cl.OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2- InChIKey
RDNLAULGBSQZMP-UHFFFAOYSA-N- Molecular formula
- C21H30ClNO
- Average molar mass
- 347.9 g/mol
- Monoisotopic mass
- 347.2015923
Overview
See also: Biperiden (has active moiety); Carapichea ipecacuanha (annotation moved to).
Names & identifiers
- Preferred name
- Biperiden Hydrochloride
- IUPAC
- 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
- English name
- Biperiden hydrochloride
- Molecular formula
- C21H30ClNO
- Molecular weight
- 347.92
Names & synonyms
Biperiden hydrochloride1235-82-1Biperiden HClAkinophylTasmolinBiperideni hydrochloridumDTXSID2047856Akineton retK35N76CUHFNSC-84989NSC-1709501-Bicycloheptenyl-1-phenyl-3-piperidinopropanol-1 hydrochloride
Show more names
BIPERIDINE HCLBicamolAkiridenNSC 84989NSC 170950Biperidene HCLBiperideni ImpurityNSC 170950NSC 84989akinetonhydrochloride
DTXCID20278321-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideCHEBI:591711-(bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideRefChem:575271-(Bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol monohydrochloride214-976-2Akineton
Database identifiers
- CAS
1235-82-1- PubChem CID
- 92151
- DTXSID
Properties
Computed structural properties
- Topological polar surface area
- 23.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 5
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 422
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 238 ° · 238°
- storage temp.
- 2 · 2-8°C
- solubility
- 20 mg/mL · DMSO: >20mg/mL
- form
- powder
- color
- off-white
- BCS Class
- 3 · 3/1
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H/t17-,18+,20,21;/s3
- InChIKey
- RDNLAULGBSQZMP-PHPHQDSFNA-N
- SMILES
- C1(C[C@]2([H])C=C[C@@]1([H])C2)C(O)(CCN1CCCCC1)C1C=CC=CC=1.Cl |&1:2,6,r|
- FDA UNII
- 35 N76CUHF · K35N76CUHF
- NIST Chemistry Reference
- Akineton, hydrochloride(1235-82-1)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H228 (66.9%): Flammable solid [Danger Flammable solids]
P210, P240, P241, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P351+P338, P317, P330, P337+P317, P370+P378, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 157 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesFlam. Sol. 1 (66.9%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Biperiden hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Safety data
- wgk
- 3
- rtecs
- TN3706000
- Toxicity
- LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
- risk_code
- 22-R22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Applications
UsesAntiparkinsonian;Anticholinergic
UsesA muscarinic receptor antagonist
UsesBiperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
General DescriptionBiperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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