Meclizine Monohydrochloride
Basic information
- CAS
1104-22-9- Standard SMILES
Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl- InChIKey
GJNMJOHYRWHJQB-UHFFFAOYSA-N- Molecular formula
- C25H28Cl2N2
- Average molar mass
- 427.4 g/mol
- Monoisotopic mass
- 426.1629543
Overview
See also: Meclizine (has active moiety).
Names & identifiers
- Preferred name
- Meclizine Monohydrochloride
- IUPAC
- 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrochloride
- English name
- Meclizine dihydrochloride
- Molecular formula
- C25H29Cl3N2
- Molecular weight
- 463.87
Names & synonyms
Meclizine MonohydrochlorideMeclozine hydrochlorideMeclozine monohydrochlorideMeclizine monohydrochloride anhydrous410538-37-3008PUV3986Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, hydrochloride (1:1)Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, monohydrochlorideANHYDROUS MECLOZINE HYDROCHLORIDERefChem:925416Duremesinmeclizine diHCl
Show more names
Meclozine HcldiadrilbonamineNSC 28728Navidoxine)-4-(3-methyLMeclizine 2HClMeclozine ,Bonamineancolandihydrochloride
36236-67-6UNII-008PUV3986MLS000028709CHEMBL1085765SMR0000587361-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrochloridePostafene dihydrochloride1-((4-Chlorophenyl)benzyl)-4-((m-tolyl)methyl)piperazine hydrochloride
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 6.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 5
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 447
Physicochemical properties
- Melting point
- 210 to · 210.0 to 214.0 °C
- storage temp.
- 2 · 2-8°C
- solubility
- 5 mg/mL, · DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- InChI
- 1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
- InChIKey
- VCTHNOIYJIXQLV-UHFFFAOYSA-N
- SMILES
- [Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.[H+].[H+]
- CAS DataBase Reference
- 1104 · 1104-22-9(CAS DataBase Reference)
- FDA UNII
- 997 QXC9J1 · L997QXC9J1
- EPA Substance Registry System
- 1 · Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07,GHS08
- Signal word
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- TL2005000
- hs_code
- 2933.59.8000
- Toxicity
- LD50 oral in mouse: 1600mg/kg
- risk_code
- 22-63
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS08
- hazard_code
- Xn
- safety_code
- 22-36
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H361
- Hazard Classifications
- Acute Tox. 4 OralRepr. 2
- Precautionary statements
- P201-P301+P312+P330-P308+P313
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used to prevent NAUSEA or VOMITING.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Applications
DescriptionMeclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
UsesMeclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
UsesAntiemetic;Histamine antagonist
Usescholinergic, diagnostic aid
Upstream & downstream products
Upstream raw materials
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