1-tert-Butoxy-2-propanol

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should keep this material in a tightly closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Remove all ignition sources. Personal protection: face shield. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.；LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a water solubility of 1.73X10+5 mg/L(2) and a regression-derived equation(3), indicates that propylene glycol mono-t-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of propylene glycol mono-t-butyl ether from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 4.73X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 4.7 mm Hg(2), and water solubility(2). The potential for volatilization of propylene glycol mono-t-butyl ether from dry soil surfaces may exist(SRC) based upon the estimated vapor pressure(2). The structurally similar compound 2-tertiary butoxy ethanol was not degraded in a 16 day BOD test(4). The authors reported that tertiary and ether structures are non-biodegradable. Based on the BOD test result for 2-tertiary butoxy ethanol(4), propylene glycol mono-t-butyl ether is not expected to biodegrade in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a water solubility of 1.73X10+5 mg/L(2) and a regression-derived equation(3), indicates that propylene glycol mono-t-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.73X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 4.7 mm Hg(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 days and 69 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 0.8(SRC), from a measured water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The structurally similar compound 2-tertiary butoxy ethanol was not degraded in a 16 day BOD test(6). The authors reported that tertiary and ether structures are non-biodegradable. Based on the BOD test result for 2-tertiary butoxy ethanol(6), propylene glycol mono-t-butyl ether is not expected to biodegrade in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propylene glycol mono-t-butyl ether, which has a vapor pressure of 4.7 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propylene glycol mono-t-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 23 hours(SRC), calculated from its rate constant of 1.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

Redness. Pain.

Cough. Nausea. Sore throat.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=57018-52-7]

The Koc of propylene glycol mono-t-butyl ether is estimated as 5(SRC), using a water solubility of 1.73X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylene glycol mono-t-butyl ether is expected to have very high mobility in soil.

Propylene glycol mono-t-butyl ether's production and use as a solvent for all-purpose cleaners, electronic chemicals, inks, adhesives, nail polish lacquers, and other water-reducible coatings(1) may result in its release to the environment through various waste streams(SRC).

The structurally similar compound 2-tertiary butoxy ethanol was not degraded in a 16 day BOD test(1). The authors reported that tertiary and ether structures are non-biodegradable. Based on the BOD test result for 2-tertiary butoxy ethanol, propylene glycol mono-t-butyl ether is not expected to be biodegradable.

1-tert-Butoxypropan-2-ol

Group 2B: Possibly carcinogenic to humans

Volume 88: (2006) Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol；Volume 119: (2019) Some Chemicals That Cause Tumours of the Urinary Tract in Rodents

2019

2017

Propylene Glycol mono- t-Butyl Ether

An estimated BCF of 0.8 was calculated for propylene glycol mono-t-butyl ether(SRC), using a water solubility of 1.73X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for propylene glycol mono-t-butyl ether is estimated as 4.73X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 4.7 mm Hg(1), and water solubility, 1.73X10+5 mg/L(1). This Henry's Law constant indicates that propylene glycol mono-t-butyl ether is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 6 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 69 days(SRC). Propylene glycol mono-t-butyl ether's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of propylene glycol mono-t-butyl ether from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

Hazard Traits - Carcinogenicity；Authoritative List - IARC Carcinogens - 2B; Prop 65；Report - regardless of intended function of ingredient in the product

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Cease Manufacture Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/9228

2-Propanol, 1-(1,1-dimethylethoxy)-: Does not have an individual approval but may be used under an appropriate group standard

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Propylene glycol mono-tert-butyl ether is included on this list.