Beta-Alanylhistidine
Basic information
- CAS
108333-82-0- Standard SMILES
NCCC(=O)NC(Cc1cnc[nH]1)C(=O)O- InChIKey
CQOVPNPJLQNMDC-UHFFFAOYSA-N- Molecular formula
- C9H14N4O3
- Average molar mass
- 226.23 g/mol
- Monoisotopic mass
- 226.10659032
Overview
See also: Malate Dehydrogenase (annotation moved to); Carnosine (annotation moved to); Malate dehydrogenase (NAD) (annotation moved to) ... View More ...
Names & identifiers
- Preferred name
- Beta-Alanylhistidine
- IUPAC
- 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
- English name
- Ribonuclease A
- Molecular formula
- NULL
- Molecular weight
- 0
Names & synonyms
108333-82-0beta-AlanylhistidineDTXSID50861860RefChem:1079608DTXCID902042779001-99-4Ribonuclease ARIBONUCLEASEDL-(3-aminopropanoyl)histidineribonuclease A from bovine pancreas2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid
Show more names
RNASE ARNASERIBONUCLEASE BRP-1RNAaseRnase IRNAase AS-RNaseabs9330
B-Ala-his-ohNuclease, ribo-L-Histidine, N-.beta.-alanyl-2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acidbeta-ALA-HISEC-Alanyl-L-histidine|A-Alanyl-L-histidineRNase A,bovine pancreas
Database identifiers
- CAS
108333-82-0、305-84-0、9001-99-4- PubChem CID
- 9369
- DTXSID
DTXSID50861860- ChEMBL
CHEMBL18545
Properties
Computed structural properties
- XLogP
- -4
- Topological polar surface area
- 121 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 6
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 259
Experimental & physicochemical properties
Chemical ClassesBiological Agents -> Enzymes
Physical DescriptionSolid; [Merck Index] Powder; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 243 °C · 243 °C (dec.)
- alpha
- 25 · D25 (per mg N) -0.47° (c = 5)
- storage temp.
- -20 °C · -20°C
- solubility
- 10 mM · Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calcium chloride
- form
- solid
- color
- white
- PH
- 8 · pH : 8.0
- biological source
- protein from bovine pancreas
- Water Solubility
- Soluble in water.
- Sensitive
- Moisture Sensitive
- Specific Activity
- 85 · 85-140Kunitz units/mg protein
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H334 (98.3%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
P233, P260, P271, P284, P304+P340, P342+P316, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 175 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
Nuclease, ribo-: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; May cause allergic reactions in sensitive individuals; [Sigma-Aldrich MSDS] See ENZYMES.
Hazard Classes and CategoriesResp. Sens. 1 (98.3%)
Safety data
- F
- 10-21
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- RF0760000
- hs_code
- 35079090
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Uses & manufacturing
UsesEnzyme that breaks down RNA; [Merck Index]
General Manufacturing InformationRibonuclease: ACTIVE
Applications
UsesRibonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas.
UsesRibonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA. Ribonuclease A from bovine pancreas has been used in a study to assess the mechanism of heavy metal ions on RNase activity. Ribonuclease A from bovine pancreas has also been used in a study to investigate the performance of oligomeric poly(diallyldimethylammonium chloride) as displacer for cation-exchange displacement chromatography of proteins.
General DescriptionHuman chromosome 14q11.2 shows the presence of all human RNases. Only eight (RNase 1-8) of them were true called as canonical RNases. And the rest nine to thirteen are called as noncanonical RNases. Human RNase 1 is called as HP-RNase or human pancreatic RNase. Human RNase 2 is also called as EDN (eosinophils derived neurotoxin) that is isolated from eosinophils.
Upstream & downstream products
Upstream raw materials
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