Basic information
- CAS
306-37-6- Standard SMILES
CNNC.Cl.Cl- InChIKey
WLDRFJDGKMTPPV-UHFFFAOYSA-N- Molecular formula
- C2H8N2.2ClH
- Average molar mass
- 133.02 g/mol
- Monoisotopic mass
- 132.02210368
Overview
Prisms (from water) or white crystalline powder. Distinct amine fishy or ammonia-like odor. (NTP, 1992)
Names & identifiers
- Preferred name
- 1,2-Dimethylhydrazine dihydrochloride
- IUPAC
- 1,2-dimethylhydrazine;dihydrochloride
- English name
- 1,2-Dimethylhydrazine Dihydrochloride
- Molecular formula
- C2H10Cl2N2
- Molecular weight
- 133.02
Names & synonyms
1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE306-37-6N,N'-Dimethylhydrazine dihydrochloride1,2-Dimethylhydrazine 2HClHydrazine, 1,2-dimethyl-, dihydrochloride1,2-Dimethylhydrazinium dichloridesym-Dimethylhydrazine dihydrochloride1,2-dimethylhydrazine;dihydrochlorideMFCD000125221,2-Dimethylhydrazine.2HClHydrazine, 1,2-dimethyl-, hydrochloride (1:2)DTXSID6020517
Show more names
s-Dimethylhydrazine1,2-DMH1,2-DimethylhydrazinediHCl1,2-Dimethylhydrazin [German]Symmetrical-dimethylhydrazine1,2-dimethylhydrazine chlorideDimethylhydrazinedihydrochlorid1,2-dimethylhydraziniumdichlorideN,N'-Dimethylhydrazinium dichloride
Dimethylhydrazinium dichloride8326154U0N1,2-dimethyl-hydrazine dihydrochlorideCCRIS 260NSC-60518EINECS 206-183-5NSC 60518UNII-8326154U0N
Database identifiers
- CAS
306-37-6- PubChem CID
- 9380
- DTXSID
DTXSID6020517- ChEMBL
CHEMBL1203772- ChEBI
CHEBI:73759- UNII
- 8326154U0N
- EC Number
- 206-183-5
Properties
Computed structural properties
- Topological polar surface area
- 24.1 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 6
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Hydrazines
Solubilitygreater than or equal to 100 mg/mL at 73 °F (NTP, 1992)
Melting Point333 to 336 °F (decomposes) (NTP, 1992)
Physical Description
Prisms (from water) or white crystalline powder. Distinct amine fishy or ammonia-like odor. (NTP, 1992)
White crystalline solid with fishy or ammonia-like odor; [CAMEO]
Physicochemical properties
- Melting point
- 167 · 167-169 °C (dec.)(lit.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Crystalline Flakes or Powder
- color
- White to light yellow
- Water Solubility
- almost transparency
- Merck
- 14 · 14,3248
- BRN
- 3905684 · 3905684
- InChI
- InChI=1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H
- InChIKey
- WLDRFJDGKMTPPV-UHFFFAOYSA-N
- SMILES
- N(C)NC.Cl.Cl
- CAS DataBase Reference
- 306 · 306-37-6(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 8326154 U0N · 8326154U0N
- EPA Substance Registry System
- 1 · 1,2-Dimethylhydrazine dihydrochloride (306-37-6)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 6 · GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- 301 · H301-H311-H331-H350
- Precautionary statements
- 201 · P201-P261-P280-P301+P310-P311
- PPE
- 3 · Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- Hazard Codes
- T,N
- Risk Statements
- 45 · 45-23/24/25-51/53
- Safety Statements
- 53 · 53-45-61
- RIDADR
- 2811 · UN 2811 6.1/PG 3
- WGK Germany
- 3 · 3
- RTECS
- 2800000 · MV2800000
- TSCA
- TSCA listed
- HazardClass
- 6.1 · 6.1(b)
- PackingGroup
- III
- HS Code
- 29280090 · 29280090
- Storage Class
- 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- 3 DermalAcute · Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Chronic 2Carc. 1B
- Toxicity
- 50 · hamster,LD50,subcutaneous,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD-A062-138,
- Limited Quantities
- 5 kg · 5.0 kg (11 lbs) (solid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Safety & regulation
GHS classification
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationChemical: Hydrazine, 1,2-dimethyl-, dihydrochloride
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards
SYMPTOMS: Symptoms of exposure to this compound may include mucous membrane and upper respiratory tract irritation, liver and kidney damage, blood effects and burns. Corneal damage may also occur. It may cause corrosion. Symptoms of exposure to this type of compound may include local irritation, convulsions, hepatotoxicity and hemolytic effects.
Hazards Summary
A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Toxic to kidneys, liver, and blood; [CAMEO] Toxic by ingestion; A skin, eye, and respiratory tract irritant; May damage the liver; [MSDSonline] See 1,2-Dimethylhydrazine.
Reactive GroupAzo, Diazo, Azido, Hydrazine, and Azide Compounds
Reactivity AlertsStrong Reducing Agent
Reactivity Profile1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE is a reducing agent. Incompatible with oxidizing agents and bases. (NTP, 1992)
Air and Water ReactionsExtremely hygroscopic. Water soluble.
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Safety & protection
Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Nonfire Spill Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE)MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Toxicology
Adverse EffectsNeurotoxin - Other CNS neurotoxin
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- MV2800000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29280090
- Toxicity
- hamster,LD50,subcutaneous,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD-A062-138,
- risk_code
- 45-23/24/25-51/53
- Signal word
- Danger
- Symbol(GHS)
- GHS06,GHS08
- hazard_code
- T,N
- safety_code
- 53-45-61
- hazard_class
- 6.1(b)
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- packing_group
- III
- Hazard statements
- H301-H311-H331-H350
- Limited Quantities
- 5.0 kg (11 lbs) (solid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
- Hazard Classifications
- Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Chronic 2Carc. 1B
- Precautionary statements
- P201-P261-P280-P301+P310-P311
Chemistry & industry
Uses & manufacturing
UsesA DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals. [ChemIDplus]
General Manufacturing InformationHydrazine, 1,2-dimethyl-, hydrochloride (1:2): ACTIVE
Applications
Uses1,2-Dimethylhydrazine is a potent carcinogen that acts as a DNA alkylating agent. It is used to induce colon tumors in experimental animals. It was also used in preparation of spiroisoquinolinedione aldose reductase inhibitors.
General DescriptionPrisms (from water) or white crystalline powder. Distinct amine fishy or ammonia-like odor.
Upstream & downstream products
Upstream raw materials
Suppliers99 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
荟达医药科技(上海)有限公司15173502222 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
南京楷煜医药科技有限公司025-86160631; 18913801556 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
苏州市森菲达化工有限公司18796480002 18796480002 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
诺达多糖（大连）医药科技有限公司13840935583 13840935583 · [email protected]
Syntechem Co.,Ltd[email protected]
Ark Pharm, Inc.847-367-3680 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
上海晶抗生物工程有限公司021-54721350 13524668266 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
广东元丰化学试剂有限公司0751-2829979 13318593351 · [email protected]
睿尚科创科技(天津)有限公司15038222995 · [email protected]
深圳市思美泉生物科技有限公司17683743113;18038040196 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
嘉兴市艾森化工有限公司0573-85285100 18627885956 · [email protected]
重庆科脉材料科技有限公司17830741407 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
武汉丰泰威远科技有限公司+86-27-8746-5837 +86-18627785180 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
湖北成海化工有限公司027-59220433 18327245847 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
HONG KONG IPURE BIOLOGY CO.,LIMITED86 18062405514 18062405514 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
上海耐士化工科技有限公司400-188-0725 +86 21 34310725 13611771617
天津希恩思生化科技有限公司400 638 7771 · [email protected]
艾科试剂4008-755-333 18080918076 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
苏州思变化学技术有限公司0512-65617459 18915409046 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
上海毕得医药科技股份有限公司400-164-7117 18317119277 · [email protected]
北京奥秘佳得医药科技有限公司+86-13522808617 · [email protected]
四川省维克奇生物科技有限公司028-81700200 18116577057 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海鑫圭生物科技有限公司15121041756 · [email protected]
Additional notes
DefinitionChEBI: A hydrochloride resulting from the reaction of 1,2,dimethylhydrazine with 2 mol eq. of hydrogen chloride.
Related reactions
28 records
Compound notes
Loading…