Basic information
- CAS
306-67-2- Standard SMILES
Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN- InChIKey
XLDKUDAXZWHPFH-UHFFFAOYSA-N- Molecular formula
- C10H30Cl4N4
- Average molar mass
- 348.2 g/mol
- Monoisotopic mass
- 346.12245768
Names & identifiers
- Preferred name
- Spermine hydrochloride
- IUPAC
- N,N'-bis(3-aminopropyl)butane-1,4-diamine;tetrahydrochloride
- English name
- Spermine tetrahydrochloride
- Molecular formula
- C10H30Cl4N4
- Molecular weight
- 348.18
Names & synonyms
Spermine tetrahydrochloride306-67-2N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochlorideSpermine hydrochlorideGerontine tetrahydrochlorideNeuridine tetrahydrochlorideSPERMINE HCLMusculamine tetrahydrochlorideEINECS 206-189-81,4-Butanediamine, N1,N4-bis(3-aminopropyl)-, hydrochloride (1:4)NSC 698521,4-BUTANEDIAMINE, N,N'-BIS(3-AMINOPROPYL)-, TETRAHYDROCHLORIDE
Show more names
Spermidine TetrahydrochlorideNEURIDINE HYDROCHLORIDEMUSCULAMINE HYDROCHLORIDESpermine4HClSperMine tetraSpermidine 4HClSpermine, TetraHClSpermine-[2H8].4HCl4-BUTANEDIAMINE 4 HCL
CCRIS 84529CI1570O484,9-Diazoniadodecamethylenediammonium tetrachloride1,4-Bis(aminopropyl)butanediamine tetrahydrochlorideDTXSID00597921,4-Butanediamino, N,N'-bis(3-aminopropyl), tetrahydrochlorideNSC-69852SPERMINE TETRAHYDROCHLORIDE [MI]
Database identifiers
- CAS
306-67-2- PubChem CID
- 9384
- DTXSID
DTXSID0059792- ChEMBL
CHEMBL1256357、CHEMBL1556584- UNII
- 9CI1570O48
- EC Number
- 206-189-8
Properties
Computed structural properties
- Topological polar surface area
- 76.1 Ų
- Hydrogen bond donors
- 8
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 11
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 86.1
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Biochemical Research
Physical DescriptionSolid; [Merck Index] White hygroscopic powder; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 310 · 310-311 °C (dec.)(lit.)
- Density
- 1.01 g/mL · 1.01 g/mL at 20 °C
- storage temp.
- room temp
- solubility
- 2 O: · H2O: 1 M at 20 °C, clear, colorless
- form
- powder
- color
- White to Almost white
- PH
- 4.5 · 4.5-7.0 (25℃, 1M in H2O)
- biological source
- synthetic
- Water Solubility
- Soluble in water (348.2 g/L at 20°C).
- λmax
- 260 nm · λ: 260 nm Amax: 0.2λ: 280 nm Amax: 0.15
- BRN
- 3911771 · 3911771
- InChI
- InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information1,4-Butanediamine, N,N'-bis(3-aminopropyl)-, tetrahydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryCauses convulsions in intraperitoneal lethal-dose studies of mice; LD50 = 370 mg/kg; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- F
- 3-10
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- EJ7230000
- hs_code
- 29212900
- risk_code
- 36/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36
Chemistry & industry
Uses & manufacturing
UsesFound widely in nature and essential for tissue growth; Used as a tool in biochemical research; [Merck Index]
General Manufacturing Information1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-, hydrochloride (1:4): ACTIVE
Applications
UsesSpermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.
UsesUsed to precipitate DNA from low salt aqueous buffers.
UsesSpermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes.
Upstream & downstream products
Upstream raw materials
Suppliers101 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
苏州道澜生物医药科技有限公司15952404857 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司
Related reactions
9 records
Compound notes
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